Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionIFP Advisors, Inc
Latest Disclosed Ownership950 shares
Latest Disclosed Value $ 71,336
IFP Advisors, Inc reports 6.31% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On April 13, 2026 - IFP Advisors, Inc filed a 13F-HR form disclosing ownership of 950 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $71,336 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 6, 2026 disclosing 1,014 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of -6.31% during the quarter. The current value of the position is $70,756 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-13 2026-03-31 13F IONIS PHARMACEUTICALS cs 462222100 950 -64 -6.31 71 -11.25 0.0015
2026-02-06 2025-12-31 13F IONIS PHARMACEUTICALS cs 462222100 1,014 -56 -5.23 80 15.94 0.0018
2026-02-06 2025-09-30 13F/A-1 IONIS PHARMACEUTICALS cs 462222100 1,070 166 18.36 70 43.75 0.0018
2025-12-02 2025-09-30 13F IONIS PHARMACEUTICALS cs 462222100 0 -904 153 0.0039
2025-07-24 2025-06-30 13F IONIS PHARMACEUTICALS cs 462222100 904 -246 -21.39 49 14.29 0.0014
2025-05-05 2025-03-31 13F IONIS PHARMACEUTICALS cs 462222100 1,150 0 0.00 42 -14.29 0.0013
2025-02-04 2024-12-31 13F IONIS PHARMACEUTICALS cs 462222100 1,150 -76 -6.20 49 0.00 0.0016
2025-02-04 2024-09-30 13F IONIS PHARMACEUTICALS cs 462222100 1,226 156 14.58 49 -2.00 0.0018
2024-07-30 2024-06-30 13F IONIS PHARMACEUTICALS cs 462222100 1,070 0 0.00 51 8.70 0.0020
2024-07-30 2024-03-31 13F IONIS PHARMACEUTICALS cs 462222100 1,070 0 0.00 46 -14.81 0.0020
2024-01-09 2023-12-31 13F IONIS PHARMACEUTICALS cs 462222100 1,070 -71 -6.22 54 5.88 0.0026
2023-10-12 2023-09-30 13F IONIS PHARMACEUTICALS cs 462222100 1,141 -14 -1.21 52 8.51 0.0023
2023-08-14 2023-06-30 13F/A-1 IONIS PHARMACEUTICALS cs 462222100 1,155 -814 -41.34 47 -48.35 0.0020
2023-08-04 2023-06-30 13F IONIS PHARMACEUTICALS cs 462222100 1,155 -814 54 0.0025
2023-04-18 2023-03-31 13F IONIS PHARMACEUTICALS cs 462222100 1,969 -2,869 -59.30 92 0.0040
2023-02-07 2022-12-31 13F IONIS PHARMACEUTICALS cs 462222100 4,838 -951 -16.43 0 -100.00 0.0062
2022-11-08 2022-09-30 13F IONIS PHARMACEUTICALS cs 462222100 5,789 0 0.00 279 0.00 0.0073
2022-09-06 2022-06-30 13F/A-1 IONIS PHARMACEUTICALS cs 462222100 5,789 0 0.00 279 0.00 0.0089
2022-09-06 2022-03-31 13F/A-1 IONIS PHARMACEUTICALS cs 462222100 5,789 3,116 116.57 279 200.00 0.0089
2022-08-08 2022-03-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 3,373 700 166 0.0034
2022-01-12 2021-12-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 2,673 953 55.41 93 40.91 0.0018
2021-10-06 2021-09-30 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 1,720 541 45.89 66 46.67 0.0013
2021-07-13 2021-06-30 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 1,179 881 295.64 45 246.15 0.0009
2021-04-30 2021-03-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 298 -83 -21.78 13 -38.10 0.0003
2021-01-25 2020-12-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 381 -518 -57.62 21 -51.16 0.0009
2020-10-29 2020-09-30 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 899 -207 -18.72 43 -34.85 0.0026
2020-08-05 2020-06-30 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 1,106 -8 -0.72 66 17.86 0.0052
2020-05-12 2020-03-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 1,114 -415 -27.14 56 -39.13 0.0057
2020-01-17 2019-12-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 1,529 -1,703 -52.69 92 -52.08 0.0069
2019-11-07 2019-09-30 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 3,232 3,192 7,980.00 192 6,300.00 0.0129
2019-05-15 2019-03-31 13F IONIS PHARMACEUTICALSINC Stock 462222100 40 -889 -95.69 3 -93.75 0.0004
2019-06-03 2018-12-31 13F/A-10 IONIS PHARMACEUTICALS INC COM Stock 462222100 929 -75 -7.47 48 -7.69 0.0029
2019-01-23 2018-12-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 929 -75 48 0.0029
2019-06-03 2018-09-30 13F/A-9 IONIS PHARMACEUTICALS INC COM Stock 462222100 1,004 -1,468 -59.39 52 -49.51 0.0021
2018-10-25 2018-09-30 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 1,004 -1,468 52 0.0021
2019-06-03 2018-06-30 13F/A-8 IONIS PHARMACEUTICALS INC COM Stock 462222100 2,472 -936 -27.46 103 -39.77 0.0043
2018-08-07 2018-06-30 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 2,472 -601 103
2019-06-03 2018-03-31 13F/A-7 IONIS PHARMACEUTICALS INC COM Stock 462222100 3,408 0 0.00 171 0.00 0.0078
2018-05-09 2018-03-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 3,073 -335 135
2019-06-03 2017-12-31 13F/A-6 IONIS PHARMACEUTICALS INC COM Stock 462222100 3,408 -1,759 -34.04 171 -34.73 0.0078
2018-01-24 2017-12-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 3,408 -1,759 171
2017-10-30 2017-09-30 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 5,167 -513 -9.03 262 -9.34 0.0104
2019-06-03 2017-06-30 13F/A-5 IONIS PHARMACEUTICALS INC COM Stock 462222100 5,680 -871 -13.30 289 9.89 0.0123
2017-07-31 2017-06-30 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 5,680 -871 289
2019-06-03 2017-03-31 13F/A-4 IONIS PHARMACEUTICALS INC COM Stock 462222100 6,551 -2,483 -27.49 263 -39.12 0.0115
2017-04-26 2017-03-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 6,551 -2,483 263
2019-06-03 2016-12-31 13F/A-3 IONIS PHARMACEUTICALS INC COM Stock 462222100 9,034 721 8.67 432 41.64 0.0208
2017-02-14 2016-12-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 9,034 721 432
2016-11-04 2016-09-30 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 8,313 1,207 16.99 305 84.85 0.0159
2019-06-03 2016-06-30 13F/A-2 IONIS PHARMACEUTICALS INC COM Stock 462222100 7,106 7,066 17,665.00 165 5,400.00 0.0092
2016-08-22 2016-06-30 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 7,106 7,066 165
2019-06-03 2016-03-31 13F/A-1 IONIS PHARMACEUTICALSINC Stock 462222100 40 -8,045 -99.51 3 -99.40 0.0004
2016-05-02 2016-03-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 8,113 28 329
2016-02-11 2015-12-31 13F IONIS PHARMACEUTICALS INC COM Stock 462222100 8,085 8,085 501 0.0336
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.