Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionFranklin Resources Inc
Latest Disclosed Ownership1,575,023 shares
Latest Disclosed Value $ 118,268,500
Franklin Resources Inc reports 19.20% increase in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 13, 2026 - Franklin Resources Inc filed a 13F-HR form disclosing ownership of 1,575,023 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $118,268,477 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 11, 2026 disclosing 1,321,345 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 19.20% during the quarter. The current value of the position is $116,268,198 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-13 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,575,023 253,678 19.20 118,268 13.14 0.0047
2026-02-11 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,321,345 1,314,752 19,941.64 104,532 24,153.13 0.0256
2025-11-13 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 6,593 1,037 18.66 431 96.80 0.0001
2025-08-12 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 5,556 5,556 220 0.0001
2025-05-13 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -13,301 -100.00 0 -100.00
2025-02-12 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 13,301 3,146 30.98 465 18.62 0.0001
2024-11-27 2024-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 10,155 133 1.33 392 -17.82 0.0001
2024-11-12 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 10,155 133 392 0.0000
2024-08-14 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 10,022 213 2.17 478 12.24 0.0001
2024-05-13 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 9,809 -3,896 -28.43 425 -38.67 0.0001
2024-02-09 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 13,705 5,256 62.21 693 80.94 0.0003
2023-11-13 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 8,449 -722 -7.87 383 1.86 0.0002
2023-08-11 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 9,171 -1,229 -11.82 376 1.35 0.0002
2023-05-12 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 10,400 -3,319 -24.19 372 -28.38 0.0002
2023-02-10 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 13,719 2,468 21.94 518 4.23 0.0003
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 11,251 11,251 497 0.0003
2021-05-13 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -3,682 -100.00 0 -100.00
2021-02-10 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 3,682 -238,669 -98.48 208 -98.19 0.0001
2020-11-12 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 242,351 2,121 0.88 11,500 -21.10 0.0056
2020-08-13 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 240,230 -443 -0.18 14,575 28.09 0.0075
2020-05-13 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 240,673 -22,927 -8.70 11,379 -28.54 0.0076
2020-03-11 2019-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 263,600 0 0.00 15,924 0.84 0.0084
2020-02-12 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 263,600 0 15,924 2,011.4192
2019-11-14 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 263,600 0 0.00 15,792 -6.79 0.0086
2019-08-14 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 263,600 -154,400 -36.94 16,942 -50.07 0.0090
2019-05-15 2019-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 418,000 268,820 180.20 33,929 320.69 0.0182
2019-05-14 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 418,000 268,820 33,929
2019-02-12 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 149,180 -341,394 -69.59 8,065 -68.13 0.0049
2018-11-13 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 490,574 -226,442 -31.58 25,303 -15.31 0.0126
2018-08-14 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 717,016 -22,740 -3.07 29,878 -8.37 0.0153
2018-05-10 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 739,756 -10,910 -1.45 32,608 -13.64 0.0165
2018-02-14 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 750,666 -176,302 -19.02 37,759 -19.66 0.0181
2017-11-13 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 926,968 -87,096 -8.59 46,997 -8.90 0.0230
2017-08-10 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,014,064 -55,970 -5.23 51,586 19.93 0.0257
2017-05-12 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,070,034 -6,500 -0.60 43,015 -16.59 0.0218
2017-02-14 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,076,534 26,820 2.55 51,573 34.08 0.0267
2016-11-14 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,049,714 -34,653 -3.20 38,464 52.31 0.0201
2016-08-11 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,084,367 -687,080 -38.79 25,253 -64.80 0.0136
2016-05-10 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,771,447 -20,300 -1.13 71,743 -35.35 0.0381
2016-04-27 2015-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,791,747 -180,707 -9.16 110,964 39.18 0.0562
2016-02-12 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,791,747 110,964
2015-11-10 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 1,972,454 2,471 0.13 79,726 -29.68 0.0394
2015-08-12 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 1,969,983 240,325 13.89 113,373 2.95 0.0515
2015-05-14 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 1,729,658 -338,291 -16.36 110,128 -13.74 0.0499
2015-02-10 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 2,067,949 -16,018 -0.77 127,676 57.78 0.0579
2014-11-12 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 2,083,967 132,449 6.79 80,921 20.36 0.0369
2014-08-12 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 1,951,518 -158,465 -7.51 67,230 -26.26 0.0296
2014-05-13 2014-03-31 13F ISIS PHARMACEUTICALS COM 464330109 2,109,983 373,329 21.50 91,172 31.77 0.0431
2014-02-12 2013-12-31 13F ISIS PHARMACEUTICALS COM 464330109 1,736,654 -218,926 -11.19 69,188 -5.75 0.0338
2013-11-14 2013-09-30 13F ISIS PHARMACEUTICALS COM 464330109 1,955,580 124,240 6.78 73,412 49.19 0.0391
2013-08-09 2013-06-30 13F ISIS PHARMACEUTICALS COM 464330109 1,831,340 1,831,340 49,208 0.0281
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.