Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionAxa S.a.
Latest Disclosed Ownership0 shares
Latest Disclosed Value $ 0
Axa S.a. closes position in IONS / Ionis Pharmaceuticals, Inc.

On November 14, 2025 - Axa S.a. filed a 13F-HR form disclosing ownership of 0 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $0 USD as of September 30, 2025. The entity filed a previous 13F-HR on August 14, 2025 disclosing 566,883 shares of Ionis Pharmaceuticals, Inc.. The current value of the position is $0 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2025-11-14 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 0 -100.00 0
2025-08-14 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 566,883 397 0.07 22,398 31.05 0.0643
2025-05-15 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 566,486 -38,859 -6.42 17,091 -19.24 0.0561
2025-02-14 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 605,345 44,102 7.86 21,163 -5.88 0.0643
2024-11-14 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 561,243 96,280 20.71 22,483 1.46 0.0666
2025-02-25 2024-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 464,963 148 0.03 22,160 9.98 0.0659
2024-08-14 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 464,963 148 22,160 0.0659
2024-05-15 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 464,815 74 0.02 20,150 -14.30 0.0604
2024-07-16 2023-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 464,741 -16,841 -3.50 23,511 7.63 0.0758
2024-02-14 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 464,741 -16,841 23,511 0.0758
2023-11-14 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 481,582 -43,582 -8.30 21,845 1.38 0.0768
2023-08-14 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 525,164 4,296 0.82 21,547 15.75 0.0716
2023-05-15 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 520,868 -702 -0.13 18,616 -5.50 0.0640
2023-02-14 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 521,570 339,214 186.02 19,700 144.25 0.0711
2023-02-14 2022-09-30 13F/A-1 Ionis Pharmaceuticals COM 462222100 182,356 23,821 15.03 8,066 37.44 0.0317
2022-11-14 2022-09-30 13F Ionis Pharmaceuticals COM 462222100 182,356 23,821 8,065 0.0317
2023-02-14 2022-06-30 13F/A-1 Ionis Pharmaceuticals COM 462222100 158,535 72,235 83.70 5,869 83.60 0.0217
2022-08-15 2022-06-30 13F Ionis Pharmaceuticals COM 462222100 158,535 72,235 5,869 0.0218
2023-02-14 2022-03-31 13F/A-1 Ionis Pharmaceuticals COM 462222100 86,300 -1,600 -1.82 3,197 19.48 0.0091
2022-05-13 2022-03-31 13F Ionis Pharmaceuticals COM 462222100 86,300 -1,600 3,197 0.0091
2022-02-14 2021-12-31 13F Ionis Pharmaceuticals COM 462222100 87,900 30,700 53.67 2,675 39.47 0.0068
2021-11-15 2021-09-30 13F Ionis Pharmaceuticals COM 462222100 57,200 57,200 1,918 0.0054
2021-08-13 2021-06-30 13F Ionis Pharmaceuticals COM 462222100 0 -192,629 -100.00 0 -100.00
2021-05-14 2021-03-31 13F Ionis Pharmaceuticals COM 462222100 192,629 19,282 11.12 8,660 -11.64 0.0264
2021-02-12 2020-12-31 13F Ionis Pharmaceuticals COM 462222100 173,347 30,422 21.29 9,801 44.51 0.0308
2021-02-11 2020-09-30 13F/A-1 Ionis Pharmaceuticals COM 462222100 142,925 85,714 149.82 6,782 101.07 0.0245
2020-11-13 2020-09-30 13F Ionis Pharmaceuticals COM 462222100 142,925 85,714 6,782 13,537.9484
2021-02-12 2020-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 57,211 -31,633 -35.61 3,373 -19.71 0.0133
2020-08-14 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 57,211 -31,633 3,373 13,301.9177
2021-02-12 2020-03-31 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 88,844 -144,802 -61.97 4,201 -70.24 0.0210
2020-06-15 2020-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 88,844 0 4,201 0.0210
2020-05-15 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 88,844 -144,802 4,201 11,683.0533
2021-02-12 2019-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 233,646 -30,476 -11.54 14,115 -10.80 0.0574
2020-02-18 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 233,646 -30,476 14,115 57,471.4539
2021-02-12 2019-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 264,122 -18,456 -6.53 15,824 -12.87 0.0630
2019-11-14 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 264,122 -18,456 15,824 63,059.6474
2021-02-12 2019-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 282,578 -22,209 -7.29 18,161 -26.59 0.0709
2019-08-13 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 282,578 -22,209 18,161 71,219.8033
2019-05-14 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 304,787 -106,688 -25.93 24,740 11.22 0.0967
2019-02-13 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 411,475 46,655 12.79 22,244 18.21 0.0970
2018-11-08 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 364,820 -69,535 -16.01 18,817 3.96 0.0690
2018-08-13 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 434,355 201,720 86.71 18,100 76.50 0.0694
2018-05-14 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 232,635 34,737 17.55 10,255 3.02 0.0409
2018-02-13 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 197,898 95,294 92.88 9,954 91.35 0.0391
2017-12-01 2017-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 102,604 102,604 5,202 0.0224
2017-11-13 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 102,604 102,604 5,202
2017-05-11 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -319,819 -100.00 0 -100.00
2017-02-13 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 319,819 -62,596 -16.37 15,297 9.17 0.0718
2016-11-10 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 382,415 29,866 8.47 14,012 70.65 0.0616
2016-08-11 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 352,549 -14,467 -3.94 8,211 -44.76 0.0366
2016-05-13 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 367,016 50,158 15.83 14,864 -24.25 0.0667
2016-02-12 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 316,858 -6,660 -2.06 19,623 50.06 0.0858
2015-11-13 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 323,518 74,146 29.73 13,077 -8.88 0.0536
2015-08-13 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 249,372 0 0.00 14,351 -9.62 0.0574
2015-05-13 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 249,372 61,726 32.89 15,878 37.06 0.0654
2015-02-13 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 187,646 12,006 6.84 11,585 69.87 0.0465
2014-11-13 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 175,640 -1,128 -0.64 6,820 11.99 0.0292
2014-08-13 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 176,768 -7,111 -3.87 6,090 -23.35 0.0253
2014-05-13 2014-03-31 13F ISIS PHARMACEUTICALS COM 464330109 183,879 9,575 5.49 7,945 14.42 0.0346
2014-02-13 2013-12-31 13F ISIS PHARMACEUTICALS COM 464330109 174,304 8,669 5.23 6,944 11.68 0.0311
2013-11-13 2013-09-30 13F ISIS PHARMACEUTICALS COM 464330109 165,635 35,237 27.02 6,218 77.45 0.0306
2013-08-12 2013-06-30 13F ISIS PHARMACEUTICALS COM 464330109 130,398 130,398 3,504 0.0186
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.