Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionAlpine Global Management, LLC
Latest Disclosed Ownership0 shares
Latest Disclosed Value $ 0
Alpine Global Management, LLC closes position in IONS / Ionis Pharmaceuticals, Inc.

On May 15, 2026 - Alpine Global Management, LLC filed a 13F-HR form disclosing ownership of 0 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $0 USD as of March 31, 2026. The entity filed a previous 13F-HR/A on February 26, 2026 disclosing 53,600 shares of Ionis Pharmaceuticals, Inc.. The current value of the position is $0 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -100.00 0
2026-02-26 2025-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 53,600 -2,300 -4.11 4,240 15.97 0.9140
2026-02-17 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 53,600 -2,300 4,240 0.7215
2025-11-21 2025-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 55,900 30,463 119.76 3,657 263.78 0.7413
2025-11-14 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 55,900 30,463 3,657 0.6297
2025-08-14 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 25,437 -2,660 -9.47 1,005 18.65 0.2265
2025-05-15 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 28,097 28,097 848 0.2244
2020-04-09 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -7,474 -100.00 0 -100.00
2020-01-16 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 7,474 7,474 452 0.0964
2016-05-12 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -20,609 -100.00 0 -100.00
2016-02-12 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 20,609 20,609 1,276 0.4091
2015-11-10 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 0 -6,676 -100.00 0 -100.00
2015-08-05 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 6,676 6,676 384 0.0645
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.