Guardant Health, Inc.
US ˙ NasdaqGS ˙ US40131M1099

SecurityGH / Guardant Health, Inc.
InstitutionSei Investments Co
Latest Disclosed Ownership261,942 shares
Latest Disclosed Value $ 26,754,474
Sei Investments Co reports 30.11% increase in ownership of GH / Guardant Health, Inc.

On February 13, 2026 - Sei Investments Co filed a 13F-HR form disclosing ownership of 261,942 shares of Guardant Health, Inc. (US:GH) valued at $26,754,756 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 13, 2025 disclosing 201,327 shares of Guardant Health, Inc.. This represents a change in shares of 30.11% during the quarter. The current value of the position is $33,274,492 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-13 2025-12-31 13F GUARDANT HEALTH COM 40131M109 261,942 60,615 30.11 26,754 112.70 0.0264
2025-11-13 2025-09-30 13F GUARDANT HEALTH COM 40131M109 201,327 124,019 160.42 12,579 212.65 0.0135
2025-08-14 2025-06-30 13F GUARDANT HEALTH COM 40131M109 77,308 -4,347 -5.32 4,023 15.67 0.0047
2025-05-14 2025-03-31 13F/A-1 GUARDANT HEALTH COM 40131M109 81,655 28,594 53.89 3,479 114.69 0.0045
2025-05-13 2025-03-31 13F GUARDANT HEALTH COM 40131M109 66,770 13,709 2,205 0.0024
2025-02-11 2024-12-31 13F GUARDANT HEALTH COM 40131M109 53,061 -9,923 -15.75 1,621 12.19 0.0021
2024-11-12 2024-09-30 13F GUARDANT HEALTH COM 40131M109 62,984 34,215 118.93 1,445 73.98 0.0019
2024-08-13 2024-06-30 13F GUARDANT HEALTH COM 40131M109 28,769 28,769 831 0.0012
2023-08-11 2023-06-30 13F GUARDANT HEALTH COM 40131M109 0 -18,785 -100.00 0 -100.00
2023-05-12 2023-03-31 13F GUARDANT HEALTH COM 40131M109 18,785 18,785 440 0.0008
2023-02-10 2022-12-31 13F GUARDANT HEALTH COM 40131M109 0 -14,889 -100.00 0 -100.00
2022-11-14 2022-09-30 13F GUARDANT HEALTH COM 40131M109 14,889 4,869 48.59 801 98.76 0.0018
2022-08-15 2022-06-30 13F GUARDANT HEALTH COM 40131M109 10,020 -12,254 -55.01 403 -72.59 0.0009
2022-05-13 2022-03-31 13F GUARDANT HEALTH COM 40131M109 22,274 -36,298 -61.97 1,470 -74.83 0.0030
2022-02-14 2021-12-31 13F GUARDANT HEALTH COM 40131M109 58,572 -3,976 -6.36 5,840 -25.27 0.0110
2021-11-12 2021-09-30 13F GUARDANT HEALTH COM 40131M109 62,548 3,517 5.96 7,815 7.05 0.0164
2021-08-06 2021-06-30 13F GUARDANT HEALTH COM 40131M109 59,031 11,995 25.50 7,300 2.17 0.0162
2021-05-12 2021-03-31 13F GUARDANT HEALTH COM 40131M109 47,036 7,070 17.69 7,145 39.12 0.0180
2021-02-08 2020-12-31 13F GUARDANT HEALTH COM 40131M109 39,966 -32 -0.08 5,136 15.26 0.0133
2020-12-04 2020-09-30 13F/A-1 GUARDANT HEALTH COM 40131M109 39,998 -5,731 -12.53 4,456 19.98 0.0129
2020-11-06 2020-09-30 13F GUARDANT HEALTH COM 40131M109 39,998 -5,731 4,456 10,729.0573
2020-08-17 2020-06-30 13F/A-1 GUARDANT HEALTH COM 40131M109 45,729 1,959 4.48 3,714 22.17 0.0115
2020-08-11 2020-06-30 13F GUARDANT HEALTH COM 40131M109 49,985 6,215 3,918 10,627.7836
2020-05-14 2020-03-31 13F GUARDANT HEALTH COM 40131M109 43,770 -23,430 -34.87 3,040 -42.08 0.0112
2020-02-06 2019-12-31 13F GUARDANT HEALTH COM 40131M109 67,200 36,015 115.49 5,249 163.64 0.0157
2019-11-12 2019-09-30 13F GUARDANT HEALTH COM 40131M109 31,185 -14,882 -32.31 1,991 -49.94 0.0051
2019-08-14 2019-06-30 13F GUARDANT HEALTH COM 40131M109 46,067 39,627 615.33 3,977 705.06 0.0130
2019-05-15 2019-03-31 13F GUARDANT HEALTH COM 40131M109 6,440 -11,113 -63.31 494 -25.15 0.0017
2019-02-13 2018-12-31 13F GUARDANT HEALTH COM 40131M109 17,553 17,553 660 0.0023
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.