Exelixis, Inc.
US ˙ NasdaqGS ˙ US30161Q1040

SecurityEXEL / Exelixis, Inc.
InstitutionSei Investments Co
Latest Disclosed Ownership1,783,389 shares
Latest Disclosed Value $ 78,166,338
Sei Investments Co reports 105.44% increase in ownership of EXEL / Exelixis, Inc.

On February 13, 2026 - Sei Investments Co filed a 13F-HR form disclosing ownership of 1,783,389 shares of Exelixis, Inc. (US:EXEL) valued at $78,165,940 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 13, 2025 disclosing 868,088 shares of Exelixis, Inc.. This represents a change in shares of 105.44% during the quarter. The current value of the position is $92,022,872 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-13 2025-12-31 13F EXELIXIS COM 30161Q104 1,783,389 915,301 105.44 78,166 118.02
2025-11-13 2025-09-30 13F EXELIXIS COM 30161Q104 868,088 -31,903 -3.54 35,853 -9.62 0.0386
2025-08-14 2025-06-30 13F EXELIXIS COM 30161Q104 899,991 247,340 37.90 39,667 64.62 0.0460
2025-05-14 2025-03-31 13F/A-1 EXELIXIS COM 30161Q104 652,651 -108,558 -14.26 24,096 -4.94 0.0310
2025-05-13 2025-03-31 13F EXELIXIS COM 30161Q104 807,514 46,305 28,363 0.0308
2025-02-11 2024-12-31 13F EXELIXIS COM 30161Q104 761,209 248,165 48.37 25,350 90.41 0.0326
2024-11-12 2024-09-30 13F EXELIXIS COM 30161Q104 513,044 224,858 78.03 13,313 105.61 0.0173
2024-08-13 2024-06-30 13F EXELIXIS COM 30161Q104 288,186 -217,133 -42.97 6,475 -46.00 0.0092
2024-05-07 2024-03-31 13F EXELIXIS COM 30161Q104 505,319 227,541 81.91 11,991 79.94 0.0176
2024-02-14 2023-12-31 13F EXELIXIS COM 30161Q104 277,778 47,943 20.86 6,664 32.70 0.0107
2023-11-14 2023-09-30 13F EXELIXIS COM 30161Q104 229,835 29,433 14.69 5,022 31.16 0.0090
2023-08-11 2023-06-30 13F EXELIXIS COM 30161Q104 200,402 -66,448 -24.90 3,830 -26.07 0.0067
2023-05-12 2023-03-31 13F EXELIXIS COM 30161Q104 266,850 -54,801 -17.04 5,180 0.39 0.0096
2023-02-10 2022-12-31 13F EXELIXIS COM 30161Q104 321,651 8,660 2.77 5,159 5.14 0.0115
2022-11-14 2022-09-30 13F EXELIXIS COM 30161Q104 312,991 215,545 221.19 4,907 149.59 0.0109
2022-08-15 2022-06-30 13F EXELIXIS COM 30161Q104 97,446 36,992 61.19 1,966 44.24 0.0042
2022-05-13 2022-03-31 13F EXELIXIS COM 30161Q104 60,454 33,554 124.74 1,363 205.61 0.0027
2022-02-14 2021-12-31 13F EXELIXIS COM 30161Q104 26,900 -1,659 -5.81 446 -22.43 0.0008
2021-11-12 2021-09-30 13F EXELIXIS COM 30161Q104 28,559 13,682 91.97 575 151.09 0.0012
2021-08-06 2021-06-30 13F EXELIXIS COM 30161Q104 14,877 3,025 25.52 229 -2.14 0.0005
2021-05-12 2021-03-31 13F EXELIXIS COM 30161Q104 11,852 0 0.00 234 0.00 0.0006
2021-02-08 2020-12-31 13F EXELIXIS COM 30161Q104 11,852 2,556 27.50 234 0.86 0.0006
2020-12-04 2020-09-30 13F/A-1 EXELIXIS COM 30161Q104 9,296 -128,147 -93.24 232 -92.92 0.0007
2020-11-06 2020-09-30 13F EXELIXIS COM 30161Q104 9,305 -128,138 232 558.6044
2020-08-17 2020-06-30 13F/A-1 EXELIXIS COM 30161Q104 137,443 137,443 3,275 0.0102
2020-08-11 2020-06-30 13F EXELIXIS COM 30161Q104 26,040 26,040 621 1,684.4956
2019-11-12 2019-09-30 13F EXELIXIS COM 30161Q104 0 -20,344 -100.00 0 -100.00
2019-08-14 2019-06-30 13F EXELIXIS COM 30161Q104 20,344 -115,764 -85.05 443 -86.29 0.0014
2019-05-15 2019-03-31 13F EXELIXIS COM 30161Q104 136,108 77,764 133.29 3,232 198.15 0.0109
2019-02-13 2018-12-31 13F EXELIXIS COM 30161Q104 58,344 23,798 68.89 1,084 78.29 0.0039
2018-11-08 2018-09-30 13F EXELIXIS COM 30161Q104 34,546 -2,318 -6.29 608 -23.43 0.0022
2018-08-03 2018-06-30 13F EXELIXIS COM 30161Q104 36,864 -25,593 -40.98 794 -42.59 0.0027
2018-05-11 2018-03-31 13F EXELIXIS COM 30161Q104 62,457 23,653 60.96 1,383 17.20 0.0053
2018-02-08 2017-12-31 13F EXELIXIS COM 30161Q104 38,804 28,681 283.33 1,180 379.67 0.0041
2017-11-06 2017-09-30 13F EXELIXIS COM 30161Q104 10,123 -92,932 -90.18 246 -90.31 0.0009
2017-07-31 2017-06-30 13F EXELIXIS COM 30161Q104 103,055 79,210 332.19 2,538 390.91 0.0101
2017-05-05 2017-03-31 13F EXELIXIS COM 30161Q104 23,845 -19,745 -45.30 517 -20.46 0.0023
2017-02-02 2016-12-31 13F EXELIXIS COM 30161Q104 43,590 -8,320 -16.03 650 -2.11 0.0031
2016-11-04 2016-09-30 13F EXELIXIS COM 30161Q104 51,910 51,910 0.00 664 0.0034
2016-05-10 2016-03-31 13F/A-1 DIREXION SHS ETF TR COM 30161Q104 0 0 0 0.0000
2016-02-03 2015-12-31 13F DIREXION SHS ETF TR COM 30161Q104 0 -107,177 -100.00 0 -100.00
2015-11-02 2015-09-30 13F/A-1 EXELIXIS COM 30161Q104 107,177 107,177 601 0.0055
2015-10-30 2015-09-30 13F DIREXION SHS ETF TR COM 30161Q104 107,177 602
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.