Design Therapeutics, Inc.
US ˙ NasdaqGS ˙ US25056L1035

SecurityDSGN / Design Therapeutics, Inc.
InstitutionXTX Topco Ltd
Latest Disclosed Ownership60,939 shares
Latest Disclosed Value $ 648,391
XTX Topco Ltd reports 72.71% increase in ownership of DSGN / Design Therapeutics, Inc.

On May 15, 2026 - XTX Topco Ltd filed a 13F-HR form disclosing ownership of 60,939 shares of Design Therapeutics, Inc. (US:DSGN) valued at $648,391 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 35,284 shares of Design Therapeutics, Inc.. This represents a change in shares of 72.71% during the quarter. The current value of the position is $655,704 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F DESIGN THERAPEUTICS COM 25056L103 60,939 25,655 72.71 648 96.36 0.0113
2026-02-17 2025-12-31 13F DESIGN THERAPEUTICS COM 25056L103 35,284 23,416 197.30 331 270.79 0.0087
2025-11-14 2025-09-30 13F DESIGN THERAPEUTICS COM 25056L103 11,868 11,868 89 0.0046
2025-05-08 2025-03-31 13F DESIGN THERAPEUTICS COM 25056L103 0 -48,424 -100.00 0 -100.00
2025-02-13 2024-12-31 13F DESIGN THERAPEUTICS COM 25056L103 48,424 48,424 299 0.0246
2024-08-12 2024-06-30 13F DESIGN THERAPEUTICS COM 25056L103 0 -15,257 -100.00 0 -100.00
2024-05-13 2024-03-31 13F DESIGN THERAPEUTICS COM 25056L103 15,257 15,257 61 0.0083
2024-02-13 2023-12-31 13F DESIGN THERAPEUTICS COM 25056L103 0 -38,472 -100.00 0 -100.00
2023-11-13 2023-09-30 13F DESIGN THERAPEUTICS COM 25056L103 38,472 27,673 256.26 91 32.35 0.0155
2023-08-14 2023-06-30 13F DESIGN THERAPEUTICS COM 25056L103 10,799 10,799 68 0.0122
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.