Bicycle Therapeutics plc - Depositary Receipt (Common Stock)
US ˙ NasdaqGS ˙ US0887861088

SecurityBCYC / Bicycle Therapeutics plc - Depositary Receipt (Common Stock)
InstitutionState Street Corp
Latest Disclosed Ownership30,512 shares
Latest Disclosed Value $ 141,576
State Street Corp reports 56.52% decrease in ownership of BCYC / Bicycle Therapeutics plc - Depositary Receipt (Common Stock)

On May 15, 2026 - State Street Corp filed a 13F-HR form disclosing ownership of 30,512 shares of Bicycle Therapeutics plc - Depositary Receipt (Common Stock) (US:BCYC) valued at $141,576 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 70,178 shares of Bicycle Therapeutics plc - Depositary Receipt (Common Stock). This represents a change in shares of -56.52% during the quarter. The current value of the position is $130,286 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 30,512 -39,666 -56.52 142 -71.57 0.0000
2026-02-13 2025-12-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 70,178 -4,227 -5.68 497 -13.74 0.0000
2025-11-14 2025-09-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 74,405 8,408 12.74 576 25.55 0.0000
2025-08-14 2025-06-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 65,997 -19,656 -22.95 459 -37.00 0.0000
2025-05-15 2025-03-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 85,653 -2,112 -2.41 727 -40.80 0.0000
2025-02-14 2024-12-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 87,765 1,494 1.73 1,229 -37.09 0.0000
2024-11-14 2024-09-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 86,271 60,399 233.45 1,952 273.23 0.0001
2024-08-14 2024-06-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 25,872 0 0.00 524 -18.79 0.0000
2024-05-15 2024-03-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 25,872 -3,694 -12.49 644 20.60 0.0000
2024-02-14 2023-12-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 29,566 -6,300 -17.57 535 -25.83 0.0000
2023-11-14 2023-09-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 35,866 27,200 313.87 721 225.79 0.0000
2023-08-14 2023-06-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 8,666 8,666 221 0.0000
2023-05-15 2023-03-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 0 -8,861 -100.00 0 -100.00
2023-05-15 2022-12-31 13F/A-99 BICYCLE THERAPEUTICS SPONSORED ADS 088786108 8,861 39 0.44 262 27.80 0.0000
2023-05-15 2022-12-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 8,861 262
2022-11-15 2022-09-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 8,822 -8,652 -49.51 205 -30.03 0.0000
2022-08-15 2022-06-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 17,474 6,787 63.51 293 -37.53 0.0000
2022-05-16 2022-03-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 10,687 2,333 27.93 469 -7.86 0.0000
2022-02-14 2021-12-31 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 8,354 1,654 24.69 509 82.44 0.0000
2021-11-15 2021-09-30 13F BICYCLE THERAPEUTICS SPONSORED ADS 088786108 6,700 6,700 279 0.0000
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.