BioCryst Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US09058V1035

SecurityBCRX / BioCryst Pharmaceuticals, Inc.
InstitutionD. E. Shaw & Co., Inc.
ManagerDE Shaw
Latest Disclosed Ownership302,101 shares
Latest Disclosed Value $ 2,876,002
D. E. Shaw & Co., Inc. reports 75.78% decrease in ownership of BCRX / BioCryst Pharmaceuticals, Inc.

On May 15, 2026 - D. E. Shaw & Co., Inc. filed a 13F-HR form disclosing ownership of 302,101 shares of BioCryst Pharmaceuticals, Inc. (US:BCRX) valued at $2,876,002 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 1,247,466 shares of BioCryst Pharmaceuticals, Inc.. This represents a change in shares of -75.78% during the quarter. The current value of the position is $2,492,333 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 302,101 -945,365 -75.78 2,876 -70.44 0.0013
2026-02-17 2025-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,247,466 -461,870 -27.02 9,730 -25.00 0.0053
2025-11-14 2025-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,709,336 -2,680,141 -61.06 12,974 -67.01 0.0073
2025-08-14 2025-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 4,389,477 2,800,365 176.22 39,330 230.00 0.0279
2025-05-15 2025-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,589,112 1,273,849 404.06 11,918 402.87 0.0106
2025-02-14 2024-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 315,263 86,173 37.62 2,371 36.13 0.0017
2024-11-14 2024-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 229,090 -121,710 -34.69 1,741 -19.66 0.0015
2024-08-14 2024-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 350,800 316,924 935.54 2,168 1,159.88 0.0020
2024-05-15 2024-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 33,876 3,245 10.59 172 -6.01 0.0001
2024-02-14 2023-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 30,631 30,631 183 0.0002
2023-11-14 2023-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -10,403 -100.00 0 -100.00
2023-08-14 2023-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 10,403 -123,320 -92.22 73 -93.45 0.0001
2023-05-15 2023-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 133,723 -399,530 -74.92 1,115 -81.78 0.0012
2023-02-14 2022-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 533,253 37,714 7.61 6,122 -1.97 0.0068
2022-11-14 2022-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 495,539 495,539 6,244 0.0075
2022-08-15 2022-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -519,050 -100.00 0 -100.00
2022-05-16 2022-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 519,050 -613,215 -54.16 8,440 -46.18 0.0079
2022-02-14 2021-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,132,265 159,731 16.42 15,682 12.21 0.0130
2021-11-15 2021-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 972,534 100,008 11.46 13,975 1.30 0.0126
2021-08-16 2021-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 872,526 811,723 1,335.00 13,795 2,132.20 0.0119
2021-05-17 2021-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 60,803 17,163 39.33 618 90.15 0.0006
2021-02-16 2020-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 43,640 43,640 -28.23 325 -47.41 0.0003
2020-08-14 2020-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -36,720 -100.00 0 -100.00
2020-05-15 2020-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 36,720 -1,722,120 -97.91 73 -98.80 0.0001
2020-02-14 2019-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,758,840 101,461 6.12 6,068 27.77 0.0069
2019-11-14 2019-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,657,379 166,025 11.13 4,749 -15.98 0.0058
2019-08-14 2019-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,491,354 152,659 11.40 5,652 -48.13 0.0070
2019-05-15 2019-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,338,695 -160,787 -10.72 10,897 -9.95 0.0141
2019-02-14 2018-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,499,482 -208,837 -12.22 12,101 -7.17 0.0167
2018-11-14 2018-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,708,319 74,447 4.56 13,035 39.23 0.0157
2018-08-14 2018-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,633,872 669,566 69.44 9,362 103.52 0.0122
2018-05-15 2018-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 964,306 24,833 2.64 4,600 -0.28 0.0063
2018-02-14 2017-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 939,473 -552,844 -37.05 4,613 -41.01 0.0064
2017-11-14 2017-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,492,317 -595,690 -28.53 7,820 -32.64 0.0120
2017-08-14 2017-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 2,088,007 -1,065,621 -33.79 11,609 -56.18 0.0192
2017-05-15 2017-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 3,153,628 -529,523 -14.38 26,491 13.62 0.0466
2017-02-14 2016-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 3,683,151 18,284 0.50 23,315 44.26 0.0396
2016-11-14 2016-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 3,664,867 231,215 6.73 16,162 65.73 0.0285
2016-08-15 2016-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 3,433,652 -621,414 -15.32 9,752 -15.02 0.0180
2016-05-16 2016-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 4,055,066 1,487,851 57.96 11,475 -56.69 0.0206
2016-02-16 2015-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 2,567,215 94,241 3.81 26,494 -6.02 0.0395
2015-11-16 2015-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 2,472,974 304,722 14.05 28,192 -12.91 0.0415
2015-08-14 2015-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 2,168,252 444,115 25.76 32,372 107.93 0.0482
2015-05-15 2015-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,724,137 53,598 3.21 15,569 -23.35 0.0238
2015-02-17 2014-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 1,670,539 -421,822 -20.16 20,313 -0.74 0.0261
2014-11-14 2014-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 2,092,361 -329,857 -13.62 20,464 -33.74 0.0265
2014-08-14 2014-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 2,422,218 353,158 17.07 30,883 41.08 0.0421
2014-05-15 2014-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 2,069,060 -371,117 -15.21 21,891 18.04 0.0312
2014-02-14 2013-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 2,440,177 1,617,669 196.68 18,545 209.70 0.0253
2013-11-20 2013-09-30 13F/A-1 BIOCRYST PHARMACEUTICALS COM 09058V103 822,508 748,058 1,004.78 5,988 5,106.96 0.0095
2013-11-14 2013-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 822,508 5,988
2013-08-14 2013-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 74,450 74,450 115 0.0002
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.