Alnylam Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US02043Q1076

SecurityALNY / Alnylam Pharmaceuticals, Inc.
InstitutionPoint72 Hong Kong Ltd
ManagerSteven Cohen
Latest Disclosed Ownership598 shares
Latest Disclosed Value $ 272,669
Point72 Hong Kong Ltd ownership in ALNY / Alnylam Pharmaceuticals, Inc.

On November 14, 2025 - Point72 Hong Kong Ltd filed a 13F-HR form disclosing ownership of 598 shares of Alnylam Pharmaceuticals, Inc. (US:ALNY) valued at $272,688 USD as of September 30, 2025. The entity filed a previous 13F-HR on August 14, 2025 disclosing 0 shares of Alnylam Pharmaceuticals, Inc.. The current value of the position is $184,585 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2025-11-14 2025-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 598 598 273 0.0125
2025-08-14 2025-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 0 -3,795 -100.00 0 -100.00
2025-05-15 2025-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,795 3,795 1,025 0.0653
2024-08-14 2024-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 0 -15,971 -100.00 0 -100.00
2024-05-15 2024-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 15,971 15,971 2,387 0.1190
2023-02-14 2022-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 0 -44,547 -100.00 0 -100.00
2022-11-14 2022-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 44,547 44,547 8,917 0.3115
2022-02-14 2021-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 0 -3,900 -100.00 0 -100.00
2021-11-15 2021-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,900 3,470 806.98 736 908.22 0.0239
2021-08-16 2021-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 430 430 73 0.0024
2021-05-17 2021-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 0 -453 -100.00 0 -100.00
2021-02-16 2020-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 453 -129 -22.16 59 -30.59 0.0027
2020-11-16 2020-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 582 -20,074 -97.18 85 -97.22 0.0090
2020-08-14 2020-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 20,656 20,656 3,449.14 3,059 3,498.82 0.3407
2020-05-15 2020-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 0 -7 -100.00 0 -100.00
2020-02-14 2019-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 7 -2,718 -99.74 1 -99.54 0.0002
2019-11-14 2019-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,725 -543 -16.62 219 -7.59 0.0632
2019-08-14 2019-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,268 3,268 19.93 237 8.22 0.0649
2019-02-14 2018-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 0 -72 -100.00 0 -100.00
2018-11-14 2018-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 72 -290 -80.11 6 -83.33 0.0021
2018-08-14 2018-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 362 362 402.78 36 500.00 0.0122
2018-05-15 2018-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 0 -1,100 -100.00 0 -100.00
2018-02-14 2017-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 1,100 560 103.70 140 122.22 0.1070
2017-11-14 2017-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 540 -96 -15.09 63 23.53 0.0447
2017-08-14 2017-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 636 -223 -25.96 51 15.91 0.0530
2017-05-15 2017-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 859 572 199.30 44 300.00 0.0575
2017-02-14 2016-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 287 -447 -60.90 11 -78.00 0.0110
2016-11-14 2016-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 734 -5,701 -88.59 50 -85.99 0.0273
2016-08-15 2016-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 6,435 400 6.63 357 -5.80 0.4140
2016-05-16 2016-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 6,035 6,035 -6.22 379 6.16 0.7391
2015-11-16 2015-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 0 -706 -100.00 0 -100.00
2015-08-14 2015-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 706 100 16.50 85 34.92 0.1650
2015-05-15 2015-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 606 -113 -15.72 63 -10.00 0.0556
2015-02-17 2014-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 719 719 70 0.0691
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.