Rhythm Pharmaceuticals, Inc.
MX ˙ BMV ˙ US76243J1051
SecurityMX:RYTM / Rhythm Pharmaceuticals, Inc.
InstitutionDeutsche Bank Ag\
Latest Disclosed Ownership141,601 shares
Latest Disclosed Value $ 12,315,039
Deutsche Bank Ag\ reports 9.66% increase in ownership of RYTM / Rhythm Pharmaceuticals, Inc.

On May 6, 2026 - Deutsche Bank Ag\ filed a 13F-HR form disclosing ownership of 141,601 shares of Rhythm Pharmaceuticals, Inc. (MX:RYTM) valued at $12,315,039 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 11, 2026 disclosing 129,123 shares of Rhythm Pharmaceuticals, Inc.. This represents a change in shares of 9.66% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-06 2026-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 141,601 12,478 9.66 12,315 -10.90 0.0041
2026-02-11 2025-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 129,123 12,381 10.61 13,821 17.24 0.0045
2025-11-13 2025-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 116,742 79,963 217.41 11,790 407.27 0.0040
2025-08-12 2025-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 36,779 -7,000 -15.99 2,324 0.26 0.0009
2025-05-09 2025-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 43,779 -4,966 -10.19 2,319 -15.03 0.0009
2025-06-30 2024-12-31 13F/A-1 RHYTHM PHARMACEUTICALS COM 76243J105 48,745 15,481 46.54 2,729 56.60 0.0011
2025-02-14 2024-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 48,745 15,481 2,729 0.0011
2025-06-26 2024-09-30 13F/A-1 RHYTHM PHARMACEUTICALS COM 76243J105 33,264 7,204 27.64 1,743 62.80 0.0007
2024-11-13 2024-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 33,264 7,204 1,743 0.0007
2025-06-12 2024-06-30 13F/A-1 RHYTHM PHARMACEUTICALS COM 76243J105 26,060 -2,099 -7.45 1,070 -12.30 0.0005
2024-08-14 2024-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 26,060 -2,099 1,070 0.0005
2025-06-02 2024-03-31 13F/A-1 RHYTHM PHARMACEUTICALS COM 76243J105 28,159 1,111 4.11 1,220 -1.85 0.0006
2024-05-15 2024-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 28,159 1,111 1,220 0.0006
2024-02-14 2023-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 27,048 -404 -1.47 1,243 97.62 0.0006
2023-11-24 2023-09-30 13F/A-1 RHYTHM PHARMACEUTICALS COM 76243J105 27,452 3,227 13.32 629 57.64 0.0004
2023-11-09 2023-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 27,452 3,227 629 0.0003
2023-08-14 2023-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 24,225 18,579 329.06 399 299.00 0.0002
2023-05-15 2023-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 5,646 0 0.00 101 -39.02 0.0001
2023-02-13 2022-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 5,646 5,646 164 0.0001
2022-08-11 2022-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 0 -227,114 -100.00 0 -100.00
2022-05-13 2022-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 227,114 200,360 748.90 2,616 879.78 0.0012
2022-02-16 2021-12-31 13F/A-1 RHYTHM PHARMACEUTICALS COM 76243J105 26,754 115 0.43 267 -23.28 0.0001
2022-02-11 2021-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 26,754 115 267 0.0000
2021-11-04 2021-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 26,639 -3,237 -10.83 348 -40.51 0.0002
2021-08-11 2021-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 29,876 -9,353 -23.84 585 -29.86 0.0003
2021-05-13 2021-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 39,229 13,171 50.54 834 7.61 0.0004
2021-02-16 2020-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 26,058 6,730 34.82 775 84.96 0.0005
2020-11-12 2020-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 19,328 1,316 7.31 419 4.49 0.0003
2020-08-13 2020-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 18,012 7,571 72.51 401 152.20 0.0003
2020-05-14 2020-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 10,441 -11,178 -51.70 159 -67.88 0.0001
2020-02-14 2019-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 21,619 14,914 222.43 495 243.75 0.0003
2019-11-14 2019-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 6,705 -6,208 -48.08 144 -48.94 0.0001
2019-08-14 2019-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 12,913 3,428 36.14 282 9.30 0.0002
2019-05-15 2019-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 9,485 4,616 94.80 258 98.46 0.0002
2019-04-01 2018-12-31 13F/A-1 RHYTHM PHARMACEUTICALS COM 76243J105 4,869 -109,684 -95.75 130 -96.11 0.0001
2019-02-14 2018-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 4,869 -79,426 130
2021-12-21 2018-09-30 13F/A-1 RHYTHM PHARMACEUTICALS COM 76243J105 114,553 61,358 115.35 3,341 100.90 0.0017
2018-11-14 2018-09-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 84,295 31,100 2,458 0.0017
2020-04-21 2018-06-30 13F/A-1 RHYTHM PHARMACEUTICALS COM 76243J105 53,195 42,547 399.58 1,663 688.15 0.0008
2018-08-14 2018-06-30 13F RHYTHM PHARMACEUTICALS COM 76243J105 48,453 37,805 1,513 1,004.9308
2019-10-23 2018-03-31 13F/A-2 RHYTHM PHARMACEUTICALS COM 76243J105 10,648 -8,085 -43.16 211 -61.07 0.0001
2019-10-18 2018-03-31 13F/A-1 RHYTHM PHARMACEUTICALS COM 76243J105 10,648 0 211 0.0001
2018-05-15 2018-03-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 8,764 -9,969 173
2018-02-14 2017-12-31 13F RHYTHM PHARMACEUTICALS COM 76243J105 18,733 18,733 542 0.0003
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.