OPKO Health, Inc.
MX ˙ BMV ˙ US68375N1037
SecurityMX:OPK / OPKO Health, Inc.
InstitutionTwo Sigma Advisers, Lp
Latest Disclosed Ownership191,201 shares
Latest Disclosed Value $ 240,913
Two Sigma Advisers, Lp reports 44.43% decrease in ownership of OPK / OPKO Health, Inc.

On February 17, 2026 - Two Sigma Advisers, Lp filed a 13F-HR form disclosing ownership of 191,201 shares of OPKO Health, Inc. (MX:OPK) valued at $240,913 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 14, 2025 disclosing 344,097 shares of OPKO Health, Inc.. This represents a change in shares of -44.43% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-17 2025-12-31 13F OPKO HEALTH COM 68375N103 191,201 -152,896 -44.43 241 -54.97 0.0005
2025-11-14 2025-09-30 13F OPKO HEALTH COM 68375N103 344,097 -304,200 -46.92 533 -37.66 0.0011
2025-08-14 2025-06-30 13F OPKO HEALTH COM 68375N103 648,297 96,600 17.51 856 -6.56 0.0018
2025-05-15 2025-03-31 13F OPKO HEALTH COM 68375N103 551,697 170,500 44.73 916 63.39 0.0021
2025-02-14 2024-12-31 13F OPKO HEALTH COM 68375N103 381,197 8,396 2.25 560 0.90 0.0013
2024-11-14 2024-09-30 13F OPKO HEALTH COM 68375N103 372,801 -89,600 -19.38 555 -3.98 0.0013
2024-08-14 2024-06-30 13F OPKO HEALTH COM 68375N103 462,401 -730,396 -61.23 578 -59.61 0.0013
2024-05-15 2024-03-31 13F OPKO HEALTH COM 68375N103 1,192,797 55,900 4.92 1,431 -16.61 0.0033
2024-02-14 2023-12-31 13F OPKO HEALTH COM 68375N103 1,136,897 -176,200 -13.42 1,717 -18.29 0.0040
2023-11-14 2023-09-30 13F OPKO HEALTH COM 68375N103 1,313,097 -126,100 -8.76 2,101 -32.76 0.0054
2023-08-14 2023-06-30 13F OPKO HEALTH COM 68375N103 1,439,197 -358,100 -19.92 3,123 19.02 0.0080
2023-05-15 2023-03-31 13F OPKO HEALTH COM 68375N103 1,797,297 -465,700 -20.58 2,624 -7.21 0.0068
2023-02-14 2022-12-31 13F OPKO HEALTH COM 68375N103 2,262,997 140,600 6.62 2,829 -29.49 0.0079
2022-11-14 2022-09-30 13F OPKO HEALTH COM 68375N103 2,122,397 1,275,600 150.64 4,011 87.25 0.0116
2022-08-15 2022-06-30 13F OPKO HEALTH COM 68375N103 846,797 504,597 147.46 2,142 81.99 0.0061
2022-05-16 2022-03-31 13F OPKO HEALTH COM 68375N103 342,200 60,900 21.65 1,177 -13.01 0.0031
2022-02-14 2021-12-31 13F OPKO HEALTH COM 68375N103 281,300 261,000 1,285.71 1,353 1,728.38 0.0034
2021-11-15 2021-09-30 13F OPKO HEALTH COM 68375N103 20,300 -92,600 -82.02 74 -83.81 0.0002
2021-08-16 2021-06-30 13F OPKO HEALTH COM 68375N103 112,900 -76,000 -40.23 457 -43.58 0.0012
2021-05-17 2021-03-31 13F OPKO HEALTH COM 68375N103 188,900 188,900 810 0.0022
2020-11-16 2020-09-30 13F OPKO HEALTH COM 68375N103 0 -908,632 -100.00 0 -100.00
2020-09-15 2020-06-30 13F/A-1 OPKO HEALTH COM 68375N103 908,632 -319,700 -26.03 3,098 88.21 0.0091
2020-08-14 2020-06-30 13F OPKO HEALTH COM 68375N103 908,632 -319,700 3,098 8,952.1911
2020-05-15 2020-03-31 13F OPKO HEALTH COM 68375N103 1,228,332 793,227 182.31 1,646 157.19 0.0063
2020-02-14 2019-12-31 13F OPKO HEALTH COM 68375N103 435,105 435,105 640 0.0015
2019-11-14 2019-09-30 13F OPKO HEALTH COM 68375N103 0 -14,025 -100.00 0 -100.00
2019-08-14 2019-06-30 13F OPKO HEALTH COM 68375N103 14,025 14,025 34 0.0001
2019-05-15 2019-03-31 13F OPKO HEALTH COM 68375N103 0 -16,400 -100.00 0 -100.00
2019-02-14 2018-12-31 13F OPKO HEALTH COM 68375N103 16,400 16,400 49 0.0001
2016-05-16 2016-03-31 13F OPKO HEALTH COM 68375N103 0 0 0 0.0000
2016-02-16 2015-12-31 13F OPKO HEALTH COM 68375N103 0 0 0 0.0000
2015-11-16 2015-09-30 13F OPKO HEALTH COM 68375N103 0 -81,211 -100.00 0 -100.00
2016-02-09 2015-06-30 13F/A-1 OPKO HEALTH COM 68375N103 81,211 81,211 0.00 1,306 0.0100
2015-08-14 2015-06-30 13F OPKO HEALTH COM 68375N103 80,811 1,298
2016-02-09 2014-12-31 13F/A-1 OPKO HEALTH COM 68375N103 0 -28,600 -100.00 0 -100.00
2016-02-09 2014-09-30 13F/A-2 OPKO HEALTH COM 68375N103 28,600 28,600 243 0.0414
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.