OPKO Health, Inc.
MX ˙ BMV ˙ US68375N1037
SecurityMX:OPK / OPKO Health, Inc.
InstitutionRhumbline Advisers
Latest Disclosed Ownership497,240 shares
Latest Disclosed Value $ 566,845
Rhumbline Advisers reports 2.78% decrease in ownership of OPK / OPKO Health, Inc.

On May 12, 2026 - Rhumbline Advisers filed a 13F-HR form disclosing ownership of 497,240 shares of OPKO Health, Inc. (MX:OPK) valued at $566,845 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 511,479 shares of OPKO Health, Inc.. This represents a change in shares of -2.78% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-12 2026-03-31 13F OPKO HEALTH COM 68375N103 497,240 -14,239 -2.78 567 -12.11 0.0005
2026-02-13 2025-12-31 13F OPKO HEALTH COM 68375N103 511,479 -43,903 -7.91 644 -25.12 0.0005
2025-11-06 2025-09-30 13F OPKO HEALTH COM 68375N103 555,382 25,829 4.88 861 23.21 0.0007
2025-08-12 2025-06-30 13F OPKO HEALTH COM 68375N103 529,553 39,274 8.01 699 -14.15 0.0006
2025-05-29 2025-03-31 13F/A-1 OPKO HEALTH COM 68375N103 490,279 -28,544 -5.50 814 6.69 0.0008
2025-04-08 2025-03-31 13F OPKO HEALTH COM 68375N103 490,279 -28,544 814 0.0008
2025-05-29 2024-12-31 13F/A-1 OPKO HEALTH COM 68375N103 518,823 -27,794 -5.08 763 -6.39 0.0007
2025-01-30 2024-12-31 13F OPKO HEALTH COM 68375N103 518,823 -27,794 763 0.0007
2024-11-12 2024-09-30 13F OPKO HEALTH COM 68375N103 546,617 -55,478 -9.21 814 8.24 0.0007
2024-08-01 2024-06-30 13F OPKO HEALTH COM 68375N103 602,095 -65,331 -9.79 753 -6.00 0.0007
2024-05-09 2024-03-31 13F OPKO HEALTH COM 68375N103 667,426 17,409 2.68 801 -18.45 0.0008
2024-02-08 2023-12-31 13F OPKO HEALTH COM 68375N103 650,017 1,132 0.17 982 -5.49 0.0010
2023-11-09 2023-09-30 13F OPKO HEALTH COM 68375N103 648,885 181 0.03 1,038 -26.23 0.0012
2023-08-08 2023-06-30 13F OPKO HEALTH COM 68375N103 648,704 -13,959 -2.11 1,408 0.0016
2023-05-11 2023-03-31 13F OPKO HEALTH COM 68375N103 662,663 19,284 3.00 1 -100.00 0.0012
2023-02-14 2022-12-31 13F OPKO HEALTH COM 68375N103 643,379 -5,327 -0.82 804 -34.42 0.0011
2022-11-10 2022-09-30 13F OPKO HEALTH COM 68375N103 648,706 42,521 7.01 1,226 -20.08 0.0018
2022-08-11 2022-06-30 13F OPKO HEALTH COM 68375N103 606,185 53,396 9.66 1,534 -19.35 0.0022
2022-05-12 2022-03-31 13F OPKO HEALTH COM 68375N103 552,789 -63,092 -10.24 1,902 -35.79 0.0024
2022-02-10 2021-12-31 13F OPKO HEALTH COM 68375N103 615,881 -4,975 -0.80 2,962 30.71 0.0036
2021-11-12 2021-09-30 13F OPKO HEALTH COM 68375N103 620,856 18,201 3.02 2,266 -7.17 0.0031
2021-08-05 2021-06-30 13F OPKO HEALTH COM 68375N103 602,655 -72,671 -10.76 2,441 -15.74 0.0032
2021-05-06 2021-03-31 13F OPKO HEALTH COM 68375N103 675,326 -38,575 -5.40 2,897 2.73 0.0039
2021-02-10 2020-12-31 13F OPKO HEALTH COM 68375N103 713,901 83,153 13.18 2,820 21.19 0.0039
2020-11-12 2020-09-30 13F OPKO HEALTH COM 68375N103 630,748 -88,290 -12.28 2,327 -5.10 0.0036
2020-08-13 2020-06-30 13F OPKO HEALTH COM 68375N103 719,038 76,646 11.93 2,452 184.79 0.0041
2020-05-06 2020-03-31 13F OPKO HEALTH COM 68375N103 642,392 60,898 10.47 861 0.70 0.0018
2020-02-05 2019-12-31 13F OPKO HEALTH COM 68375N103 581,494 30,997 5.63 855 -25.72 0.0014
2019-10-23 2019-09-30 13F OPKO HEALTH COM 68375N103 550,497 53,557 10.78 1,151 -5.11 0.0021
2019-08-14 2019-06-30 13F OPKO HEALTH COM 68375N103 496,940 25,594 5.43 1,213 -1.38 0.0023
2019-05-01 2019-03-31 13F OPKO HEALTH COM 68375N103 471,346 -4,504 -0.95 1,230 -14.11 0.0024
2019-01-31 2018-12-31 13F OPKO HEALTH COM 68375N103 475,850 137,968 40.83 1,432 22.50 0.0031
2018-11-07 2018-09-30 13F OPKO HEALTH COM 68375N103 337,882 714 0.21 1,169 -26.25 0.0023
2018-08-06 2018-06-30 13F OPKO HEALTH COM 68375N103 337,168 19,316 6.08 1,585 57.24 0.0032
2018-05-02 2018-03-31 13F OPKO HEALTH COM 68375N103 317,852 -6,261 -1.93 1,008 -36.52 0.0021
2018-02-09 2017-12-31 13F OPKO HEALTH COM 68375N103 324,113 -3,458 -1.06 1,588 -29.33 0.0032
2017-11-06 2017-09-30 13F OPKO HEALTH COM 68375N103 327,571 343 0.10 2,247 4.37 0.0049
2017-08-02 2017-06-30 13F OPKO HEALTH COM 68375N103 327,228 -45,022 -12.09 2,153 -27.70 0.0049
2017-05-02 2017-03-31 13F OPKO HEALTH COM 68375N103 372,250 14,377 4.02 2,978 -10.52 0.0070
2017-01-27 2016-12-31 13F OPKO HEALTH COM 68375N103 357,873 27,652 8.37 3,328 -4.83 0.0084
2016-11-08 2016-09-30 13F OPKO HEALTH COM 68375N103 330,221 17,101 5.46 3,497 19.56 0.0096
2016-08-11 2016-06-30 13F OPKO HEALTH COM 68375N103 313,120 35,460 12.77 2,925 1.39 0.0087
2016-05-02 2016-03-31 13F OPKO HEALTH INC U COM 68375N103 277,660 -6,288 -2.21 2,885 1.09 0.0090
2016-02-03 2015-12-31 13F OPKO HEALTH INC U COM 68375N103 283,948 2,129 0.76 2,854 20.42 0.0092
2015-11-04 2015-09-30 13F OPKO HEALTH INC U COM 68375N103 281,819 71,486 33.99 2,370 -29.92 0.0081
2015-08-04 2015-06-30 13F OPKO HEALTH INC U COM 68375N103 210,333 5,298 2.58 3,382 16.42 0.0108
2015-05-12 2015-03-31 13F OPKO HEALTH INC U COM 68375N103 205,035 30,650 17.58 2,905 66.76 0.0084
2015-02-06 2014-12-31 13F OPKO HEALTH INC U COM 68375N103 174,385 -4,437 -2.48 1,742 14.45 0.0051
2014-11-12 2014-09-30 13F OPKO HEALTH INC U COM 68375N103 178,822 -85 -0.05 1,522 -3.79 0.0046
2014-08-06 2014-06-30 13F OPKO HEALTH INC U COM 68375N103 178,907 15,343 9.38 1,582 3.81 0.0046
2014-05-06 2014-03-31 13F OPKO HEALTH INC U COM 68375N103 163,564 -7,020 -4.12 1,524 5.83 0.0045
2014-02-03 2013-12-31 13F OPKO HEALTH INC U COM 68375N103 170,584 9,350 5.80 1,440 1.41 0.0042
2013-11-05 2013-09-30 13F OPKO HEALTH INC U COM 68375N103 161,234 11,745 7.86 1,420 33.84 0.0044
2013-08-07 2013-06-30 13F OPKO HEALTH INC U COM 68375N103 149,489 149,489 1,061 0.0034
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.