OPKO Health, Inc.
MX ˙ BMV ˙ US68375N1037
SecurityMX:OPK / OPKO Health, Inc.
InstitutionPrincipal Financial Group Inc
Latest Disclosed Ownership17,740 shares
Latest Disclosed Value $ 20,224
Principal Financial Group Inc reports 0.07% decrease in ownership of OPK / OPKO Health, Inc.

On May 4, 2026 - Principal Financial Group Inc filed a 13F-HR form disclosing ownership of 17,740 shares of OPKO Health, Inc. (MX:OPK) valued at $20,224 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 2, 2026 disclosing 17,752 shares of OPKO Health, Inc.. This represents a change in shares of -0.07% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-04 2026-03-31 13F OPKO HEALTH COM 68375N103 17,740 -12 -0.07 20 -9.09 0.0000
2026-02-02 2025-12-31 13F OPKO HEALTH COM 68375N103 17,752 -10,985 -38.23 22 -50.00 0.0000
2025-11-04 2025-09-30 13F OPKO HEALTH COM 68375N103 28,737 3,964 16.00 45 37.50 0.0000
2025-08-08 2025-06-30 13F OPKO HEALTH COM 68375N103 24,773 3,648 17.27 33 -8.57 0.0000
2025-04-28 2025-03-31 13F OPKO HEALTH COM 68375N103 21,125 3,093 17.15 35 34.62 0.0000
2025-01-31 2024-12-31 13F OPKO HEALTH COM 68375N103 18,032 -4,708 -20.70 27 -21.21 0.0000
2024-10-31 2024-09-30 13F OPKO HEALTH COM 68375N103 22,740 -9,201 -28.81 34 -15.38 0.0000
2024-07-29 2024-06-30 13F OPKO HEALTH COM 68375N103 31,941 -12,909 -28.78 40 -26.42 0.0000
2024-04-29 2024-03-31 13F OPKO HEALTH COM 68375N103 44,850 -6,264 -12.25 54 -31.17 0.0000
2024-02-07 2023-12-31 13F OPKO HEALTH COM 68375N103 51,114 -8,452 -14.19 77 -18.95 0.0000
2023-11-02 2023-09-30 13F OPKO HEALTH COM 68375N103 59,566 16,733 39.07 95 3.26 0.0001
2023-08-07 2023-06-30 13F OPKO HEALTH COM 68375N103 42,833 -68,542 -61.54 93 -43.21 0.0001
2023-05-09 2023-03-31 13F OPKO HEALTH COM 68375N103 111,375 3,515 3.26 163 20.90 0.0001
2023-02-09 2022-12-31 13F OPKO HEALTH COM 68375N103 107,860 -95,707 -47.01 135 -65.19 0.0001
2022-11-09 2022-09-30 13F OPKO HEALTH COM 68375N103 203,567 -121,918 -37.46 385 -53.22 0.0003
2022-08-10 2022-06-30 13F OPKO HEALTH COM 68375N103 325,485 -30,555 -8.58 823 -32.82 0.0006
2022-05-09 2022-03-31 13F OPKO HEALTH COM 68375N103 356,040 -132,035 -27.05 1,225 -47.81 0.0005
2022-05-09 2022-03-31 13F OPKO HEALTH COM 68375N103 324,041 1,115
2022-02-09 2021-12-31 13F OPKO HEALTH COM 68375N103 488,075 -506,797 -50.94 2,347 -35.36 0.0014
2021-11-09 2021-09-30 13F OPKO HEALTH COM 68375N103 994,872 1,938 0.20 3,631 -9.72 0.0024
2021-08-10 2021-06-30 13F OPKO HEALTH COM 68375N103 992,934 -172,935 -14.83 4,022 -19.59 0.0026
2021-05-10 2021-03-31 13F OPKO HEALTH COM 68375N103 1,165,869 121,823 11.67 5,002 21.29 0.0035
2021-02-23 2020-12-31 13F/A-1 OPKO HEALTH COM 68375N103 1,044,046 55,092 5.57 4,124 13.02 0.0031
2021-02-08 2020-12-31 13F OPKO HEALTH COM 68375N103 1,044,046 55,092 4,124 1,622.4452
2020-11-06 2020-09-30 13F OPKO HEALTH COM 68375N103 988,954 361,146 57.52 3,649 70.43 0.0031
2020-08-05 2020-06-30 13F OPKO HEALTH COM 68375N103 627,808 333,155 113.07 2,141 442.03 0.0019
2020-05-12 2020-03-31 13F OPKO HEALTH COM 68375N103 294,653 17,674 6.38 395 -2.95 0.0004
2020-02-05 2019-12-31 13F OPKO HEALTH COM 68375N103 276,979 -21,209 -7.11 407 -34.67 0.0003
2019-11-13 2019-09-30 13F OPKO HEALTH COM 68375N103 298,188 21,499 7.77 623 -7.70 0.0005
2019-08-12 2019-06-30 13F OPKO HEALTH COM 68375N103 276,689 162,865 143.08 675 127.27 0.0006
2019-05-10 2019-03-31 13F OPKO HEALTH COM 68375N103 113,824 -2,325 -2.00 297 -15.14 0.0003
2019-02-14 2018-12-31 13F OPKO HEALTH COM 68375N103 116,149 -8,709 -6.98 350 -18.98 0.0004
2018-11-14 2018-09-30 13F OPKO HEALTH COM 68375N103 124,858 406 0.33 432 -26.15 0.0004
2018-08-13 2018-06-30 13F OPKO HEALTH COM 68375N103 124,452 -16,127 -11.47 585 31.17 0.0005
2018-05-14 2018-03-31 13F OPKO HEALTH COM 68375N103 140,579 7,353 5.52 446 -31.70 0.0004
2018-02-12 2017-12-31 13F OPKO HEALTH COM 68375N103 133,226 75,156 129.42 653 64.07 0.0006
2017-11-02 2017-09-30 13F OPKO HEALTH COM 68375N103 58,070 -4,678 -7.46 398 -3.40 0.0004
2017-08-08 2017-06-30 13F OPKO HEALTH COM 68375N103 62,748 -6,350 -9.19 412 -25.50 0.0004
2017-05-11 2017-03-31 13F OPKO HEALTH COM 68375N103 69,098 -2,125 -2.98 553 -16.59 0.0007
2017-02-13 2016-12-31 13F OPKO HEALTH COM 68375N103 71,223 -9,448 -11.71 663 -22.37 0.0008
2016-11-10 2016-09-30 13F OPKO HEALTH COM 68375N103 80,671 15,683 24.13 854 40.69 0.0011
2016-08-09 2016-06-30 13F OPKO HEALTH COM 68375N103 64,988 9,096 16.27 607 4.48 0.0008
2016-05-10 2016-03-31 13F OPKO HEALTH COM 68375N103 55,892 618 1.12 581 4.50 0.0008
2016-02-09 2015-12-31 13F OPKO HEALTH COM 68375N103 55,274 206 0.37 556 20.09 0.0008
2015-11-12 2015-09-30 13F/A-1 OPKO HEALTH COM 68375N103 55,068 -14,862 -21.25 463 -58.81 0.0007
2015-11-09 2015-09-30 13F OPKO HEALTH COM 68375N103 55,068 463
2015-08-10 2015-06-30 13F OPKO HEALTH COM 68375N103 69,930 38,152 120.06 1,124 149.78 0.0017
2015-05-14 2015-03-31 13F/A-1 OPKO HEALTH COM 68375N103 31,778 -4,589 -12.62 450 23.97 0.0007
2015-05-12 2015-03-31 13F OPKO HEALTH COM 68375N103 31,778 450
2015-02-12 2014-12-31 13F OPKO HEALTH COM 68375N103 36,367 -4,649 -11.33 363 4.01 0.0006
2014-11-13 2014-09-30 13F OPKO HEALTH COM 68375N103 41,016 0 0.00 349 -3.86 0.0006
2014-08-12 2014-06-30 13F OPKO HEALTH COM 68375N103 41,016 -11,155 -21.38 363 -25.31 0.0006
2014-05-13 2014-03-31 13F OPKO HEALTH COM 68375N103 52,171 -7,505 -12.58 486 -3.57 0.0009
2014-02-12 2013-12-31 13F OPKO HEALTH COM 68375N103 59,676 268 0.45 504 -3.63 0.0009
2013-11-05 2013-09-30 13F OPKO HEALTH COM 68375N103 59,408 27,122 84.01 523 128.38 0.0011
2013-08-12 2013-06-30 13F OPKO HEALTH COM 68375N103 32,286 32,286 229 0.0005
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.