OPKO Health, Inc.
MX ˙ BMV ˙ US68375N1037
SecurityMX:OPK / OPKO Health, Inc.
InstitutionFirst Trust Advisors Lp
Latest Disclosed Ownership500,273 shares
Latest Disclosed Value $ 570,311
First Trust Advisors Lp ownership in OPK / OPKO Health, Inc.

On May 13, 2026 - First Trust Advisors Lp filed a 13F-HR form disclosing ownership of 500,273 shares of OPKO Health, Inc. (MX:OPK) valued at $570,311 USD as of March 31, 2026. The entity filed a previous 13F-HR on August 13, 2024 disclosing 0 shares of OPKO Health, Inc..

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-13 2026-03-31 13F OPKO HEALTH COM 68375N103 500,273 500,273 570 0.0004
2024-08-13 2024-06-30 13F OPKO HEALTH COM 68375N103 0 -100.00 0
2024-05-13 2024-03-31 13F OPKO HEALTH COM 68375N103 368,160 62,429 20.42 442 -4.34 0.0004
2024-02-13 2023-12-31 13F OPKO HEALTH COM 68375N103 305,731 305,731 462 0.0005
2023-08-14 2023-06-30 13F OPKO HEALTH COM 68375N103 0 -393,583 -100.00 0 -100.00
2023-05-15 2023-03-31 13F OPKO HEALTH COM 68375N103 393,583 393,583 575 0.0007
2023-02-09 2022-12-31 13F OPKO HEALTH COM 68375N103 0 -190,553 -100.00 0 -100.00
2022-11-14 2022-09-30 13F OPKO HEALTH COM 68375N103 190,553 21,846 12.95 360 -15.69 0.0005
2022-08-12 2022-06-30 13F OPKO HEALTH COM 68375N103 168,707 -165,160 -49.47 427 -62.84 0.0005
2022-05-13 2022-03-31 13F OPKO HEALTH COM 68375N103 333,867 -160,231 -32.43 1,149 -51.66 0.0012
2022-02-08 2021-12-31 13F OPKO HEALTH COM 68375N103 494,098 -480,834 -49.32 2,377 -33.21 0.0023
2021-11-15 2021-09-30 13F OPKO HEALTH COM 68375N103 974,932 -494,162 -33.64 3,559 -40.18 0.0038
2021-10-12 2021-06-30 13F/A-1 OPKO HEALTH COM 68375N103 1,469,094 270,772 22.60 5,950 15.74 0.0064
2021-08-16 2021-06-30 13F OPKO HEALTH COM 68375N103 1,469,094 270,772 5,950 0.0062
2021-05-14 2021-03-31 13F OPKO HEALTH COM 68375N103 1,198,322 25,337 2.16 5,141 10.96 0.0062
2021-02-02 2020-12-31 13F OPKO HEALTH COM 68375N103 1,172,985 1,172,985 -2.11 4,633 -9.88 0.0061
2019-02-07 2018-12-31 13F OPKO HEALTH COM 68375N103 0 -129,435 -100.00 0 -100.00
2018-10-25 2018-09-30 13F OPKO HEALTH COM 68375N103 129,435 129,435 448 0.0008
2018-04-23 2018-03-31 13F OPKO HEALTH COM 68375N103 0 -31,328 -100.00 0 -100.00
2018-02-08 2017-12-31 13F OPKO HEALTH COM 68375N103 31,328 31,328 154 0.0004
2017-08-02 2017-06-30 13F OPKO HEALTH COM 68375N103 0 -489,958 -100.00 0 -100.00
2017-05-02 2017-03-31 13F OPKO HEALTH COM 68375N103 489,958 -858,753 -63.67 3,920 -68.75 0.0109
2017-02-06 2016-12-31 13F OPKO HEALTH COM 68375N103 1,348,711 1,348,711 175.27 12,543 219.97 0.0373
2016-11-01 2016-09-30 13F OPKO HEALTH COM 68375N103 0 -1,526,964 -100.00 0 -100.00
2016-08-04 2016-06-30 13F OPKO HEALTH COM 68375N103 1,526,964 950,355 164.82 14,262 138.06 0.0449
2016-05-10 2016-03-31 13F OPKO HEALTH COM 68375N103 576,609 576,609 -62.24 5,991 -57.99 0.0192
2016-05-04 2015-12-31 13F/A-1 OPKO HEALTH COM 68375N103 0 -4,605,196 -100.00 0 -100.00
2015-11-05 2015-09-30 13F OPKO HEALTH COM 68375N103 4,605,196 4,605,196 38,730 0.1122
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.