Neurocrine Biosciences, Inc.
MX ˙ BMV ˙ US64125C1099
SecurityMX:NBIX / Neurocrine Biosciences, Inc.
InstitutionTwo Sigma Advisers, Lp
Latest Disclosed Ownership842,592 shares
Latest Disclosed Value $ 119,504,823
Two Sigma Advisers, Lp reports 466.36% increase in ownership of NBIX / Neurocrine Biosciences, Inc.

On February 17, 2026 - Two Sigma Advisers, Lp filed a 13F-HR form disclosing ownership of 842,592 shares of Neurocrine Biosciences, Inc. (MX:NBIX) valued at $119,504,823 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 14, 2025 disclosing 148,773 shares of Neurocrine Biosciences, Inc.. This represents a change in shares of 466.36% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-17 2025-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 842,592 693,819 466.36 119,505 472.23 0.2324
2025-11-14 2025-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 148,773 148,773 20,885 0.0418
2025-08-14 2025-06-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 0 -3,600 -100.00 0 -100.00
2025-05-15 2025-03-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 3,600 3,600 398 0.0009
2025-02-14 2024-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 0 -3,873 -100.00 0 -100.00
2024-11-14 2024-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 3,873 -30,900 -88.86 446 -90.68 0.0010
2024-08-14 2024-06-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 34,773 -160,500 -82.19 4,787 -82.23 0.0107
2024-05-15 2024-03-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 195,273 -15,200 -7.22 26,932 -2.88 0.0624
2024-02-14 2023-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 210,473 -84,400 -28.62 27,732 -16.40 0.0649
2023-11-14 2023-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 294,873 -259,400 -46.80 33,173 -36.53 0.0850
2023-08-14 2023-06-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 554,273 -124,500 -18.34 52,268 -23.93 0.1331
2023-05-15 2023-03-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 678,773 -43,900 -6.07 68,705 -20.40 0.1772
2023-02-14 2022-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 722,673 127,700 21.46 86,316 36.59 0.2410
2022-11-14 2022-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 594,973 130,100 27.99 63,192 39.45 0.1829
2022-08-15 2022-06-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 464,873 -163,900 -26.07 45,316 -23.12 0.1286
2022-05-16 2022-03-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 628,773 435,600 225.50 58,947 258.28 0.1567
2022-02-14 2021-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 193,173 176,300 1,044.86 16,453 916.87 0.0412
2021-11-15 2021-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 16,873 16,873 1,618 0.0042
2021-02-16 2020-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 0 -430,299 -100.00 0 -100.00
2020-11-16 2020-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 430,299 -297,874 -40.91 41,378 -53.42 0.1182
2020-09-15 2020-06-30 13F/A-1 NEUROCRINE BIOSCIENCES COM 64125C109 728,173 9,500 1.32 88,837 42.82 0.2610
2020-08-14 2020-06-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 728,173 9,500 88,837 256,709.4259
2020-05-15 2020-03-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 718,673 -112,500 -13.54 62,201 -30.38 0.2380
2020-02-14 2019-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 831,173 98,200 13.40 89,343 35.27 0.2073
2019-11-14 2019-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 732,973 -66,300 -8.30 66,048 -2.13 0.1617
2019-08-14 2019-06-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 799,273 42,400 5.60 67,483 1.20 0.1679
2019-05-15 2019-03-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 756,873 134,400 21.59 66,681 50.01 0.1681
2019-02-14 2018-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 622,473 77,000 14.12 44,451 -33.72 0.1214
2018-11-14 2018-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 545,473 238,400 77.64 67,066 122.32 0.1637
2018-08-14 2018-06-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 307,073 277,400 934.86 30,167 1,125.80 0.0811
2018-05-15 2018-03-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 29,673 18,561 167.04 2,461 185.50 0.0067
2018-02-14 2017-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 11,112 11,112 862 0.0023
2017-11-14 2017-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 0 -11,600 -100.00 0 -100.00
2017-08-14 2017-06-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 11,600 -6,900 -37.30 534 -33.33 0.0018
2017-05-15 2017-03-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 18,500 0 0.00 801 11.87 0.0026
2017-02-14 2016-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 18,500 11,327 157.91 716 97.25 0.0027
2016-11-14 2016-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 7,173 7,173 0.00 363 0.0015
2016-08-15 2016-06-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 0 -39,973 -100.00 0 -100.00
2016-05-16 2016-03-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 39,973 10,400 35.17 1,581 -5.50 0.0088
2016-02-16 2015-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 29,573 -37,500 -55.91 1,673 -37.67 0.0100
2015-11-16 2015-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 67,073 48,500 261.13 2,684 202.59 0.0169
2016-02-09 2015-06-30 13F/A-1 NEUROCRINE BIOSCIENCES COM 64125C109 18,573 2,600 16.28 887 39.91 0.0068
2015-08-14 2015-06-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 18,573 887
2016-02-09 2015-03-31 13F/A-1 NEUROCRINE BIOSCIENCES COM 64125C109 15,973 15,973 -9.10 634 130.55 0.0049
2015-05-15 2015-03-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 15,973 634
2015-02-17 2014-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 0 -17,573 -100.00 0 -100.00
2016-02-09 2014-09-30 13F/A-1 NEUROCRINE BIOSCIENCES COM 64125C109 17,573 -600 -3.30 275 61.76 0.0022
2014-11-14 2014-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 16,973 266
2014-02-14 2013-12-31 13F NEUROCRINE BIOSCIENCES COM 64125C109 18,173 18,173 28.55 170 -10.05 0.0016
2013-11-14 2013-09-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 0 -14,137 -100.00 0 -100.00
2013-08-14 2013-06-30 13F NEUROCRINE BIOSCIENCES COM 64125C109 14,137 14,137 189 0.0027
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.