Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionTd Asset Management Inc
Latest Disclosed Ownership529,954 shares
Latest Disclosed Value $ 39,794,246
Td Asset Management Inc reports 31.46% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 11, 2026 - Td Asset Management Inc filed a 13F-HR form disclosing ownership of 529,954 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $39,794,246 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 10, 2026 disclosing 773,184 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of -31.46% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-11 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 529,954 -243,230 -31.46 39,794 -34.94 0.0173
2026-02-10 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 773,184 -187,088 -19.48 61,167 -2.63 0.0492
2025-11-10 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 960,272 -144,418 -13.07 62,821 43.93 0.0510
2025-07-28 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,104,690 4,224 0.38 43,646 31.46 0.0373
2025-05-07 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,100,466 50,476 4.81 33,201 -9.55 0.0306
2025-02-11 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,049,990 -43,000 -3.93 36,708 -17.79 0.0325
2024-11-01 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,092,990 140,228 14.72 44,649 -1.67 0.0394
2024-08-02 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 952,762 54,400 6.06 45,409 16.60 0.0423
2024-05-08 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 898,362 -58,490 -6.11 38,944 -19.55 0.0362
2024-02-12 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 956,852 58,000 6.45 48,407 18.73 0.0476
2023-10-27 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 898,852 113,644 14.47 40,772 26.55 0.0494
2023-08-09 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 785,208 -32,100 -3.93 32,217 10.29 0.0367
2023-05-10 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 817,308 37,813 4.85 29,211 -0.78 0.0353
2023-02-07 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 779,495 -24,588 -3.06 29,442 -17.31 0.0363
2022-11-07 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 804,083 419 0.05 35,605 19.67 0.0446
2022-08-04 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 803,664 -16,500 -2.01 29,752 -2.06 0.0345
2022-05-10 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 820,164 77,000 10.36 30,379 34.34 0.0179
2022-02-10 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 743,164 321,200 76.12 22,614 59.78 0.0189
2021-11-09 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 421,964 100 0.02 14,153 -9.67 0.0147
2021-08-11 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 421,864 -2,715 -0.64 15,668 -17.92 0.0159
2021-05-14 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 424,579 39,235 10.18 19,089 -12.38 0.0213
2021-02-16 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 385,344 105,697 37.80 21,787 64.19 0.0265
2020-11-10 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 279,647 72,605 35.07 13,269 8.70 0.0184
2020-08-13 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 207,042 111,277 116.20 12,207 169.59 0.0174
2020-05-15 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 95,765 53,862 128.54 4,528 78.90 0.0077
2020-02-11 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 41,903 -5,200 -11.04 2,531 -10.31 0.0037
2019-11-07 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 47,103 -1,600 -3.29 2,822 -9.84 0.0043
2019-08-01 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 48,703 -22,700 -31.79 3,130 -46.00 0.0047
2019-05-08 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 71,403 49,900 232.06 5,796 398.80 0.0088
2019-02-01 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 21,503 1,900 9.69 1,162 14.94 0.0020
2018-11-01 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 19,603 -2,000 -9.26 1,011 12.33 0.0015
2018-07-31 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 21,603 -500 -2.26 900 -7.60 0.0014
2018-05-11 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 22,103 -2,000 -8.30 974 -19.64 0.0015
2018-02-02 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 24,103 6,300 35.39 1,212 34.22 0.0018
2017-11-09 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 17,803 -997 -5.30 903 -5.54 0.0014
2017-08-01 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 18,800 -13,300 -41.43 956 -25.89 0.0015
2017-05-05 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 32,100 -1,500 -4.46 1,290 -19.73 0.0021
2017-02-08 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 33,600 23,900 246.39 1,607 352.68 0.0027
2016-11-02 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 9,700 -10,420 -51.79 355 -24.31 0.0006
2016-08-04 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 20,120 1,620 8.76 469 -37.38 0.0009
2016-05-05 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 18,500 0 0.00 749 -34.64 0.0014
2016-02-04 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 18,500 2,100 12.80 1,146 72.85 0.0023
2015-11-12 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 16,400 0 0.00 663 -29.77 0.0013
2015-08-11 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 16,400 1,300 8.61 944 -1.77 0.0017
2015-04-28 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 15,100 15,100 0.00 961 0.0017
2015-01-30 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 0 -53,900 -100.00 0 -100.00
2014-11-06 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 53,900 1,100 2.08 2,093 15.06 0.0036
2014-08-12 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 52,800 -18,500 -25.95 1,819 -40.96 0.0031
2014-05-09 2014-03-31 13F ISIS PHARMACEUTICALS COM 464330109 71,300 500 0.71 3,081 9.22 0.0056
2014-02-07 2013-12-31 13F ISIS PHARMACEUTICALS COM 464330109 70,800 3,700 5.51 2,821 11.99 0.0053
2013-11-08 2013-09-30 13F ISIS PHARMACEUTICALS COM 464330109 67,100 -4,900 -6.81 2,519 30.18 0.0050
2013-07-24 2013-06-30 13F ISIS PHARMACEUTICALS COM 464330109 72,000 72,000 1,935 0.0042
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.