Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionHsbc Holdings Plc
Latest Disclosed Ownership185,967 shares
Latest Disclosed Value $ 13,966,721
Hsbc Holdings Plc reports 590.28% increase in ownership of IONS / Ionis Pharmaceuticals, Inc.

On April 30, 2026 - Hsbc Holdings Plc filed a 13F-HR form disclosing ownership of 185,967 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $13,966,721 USD as of March 31, 2026. The entity filed a previous 13F-HR/A on March 20, 2026 disclosing 26,941 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 590.28% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-30 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 185,967 159,026 590.28 13,967 552.31 0.0010
2026-03-20 2025-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 26,941 -18,515 -40.73 2,142 -27.35 0.0001
2026-03-06 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 26,941 -18,515 -40.73 2,142 -27.35 0.0001
2025-11-13 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 45,456 -62,838 -58.03 2,947 -31.35 0.0002
2025-08-13 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 108,294 33,461 44.71 4,294 93.29 0.0026
2025-05-14 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 74,833 -8,222 -9.90 2,222 -24.12 0.0014
2025-02-14 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 83,055 83,055 2,928 0.0017
2024-11-14 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 0 -5,326 -100.00 0 -100.00
2024-08-12 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 5,326 5,326 252 0.0002
2023-08-11 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 0 -6,623 -100.00 0 -100.00
2023-05-15 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 6,623 6,623 234 0.0003
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 0 -47,206 -100.00 0 -100.00
2022-08-11 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 47,206 40,609 615.57 1,776 633.88 0.0025
2022-05-16 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 6,597 6,597 242 0.0003
2021-11-12 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 0 -9,435 -100.00 0 -100.00
2021-08-13 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 9,435 -4,980 -34.55 376 -41.98 0.0004
2021-05-14 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 14,415 -2,919 -16.84 648 -33.61 0.0008
2021-02-25 2020-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 17,334 -25,841 -59.85 976 -52.71 0.0013
2021-02-12 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 17,334 -25,841 976 231.7383
2020-11-12 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 43,175 30,731 246.95 2,064 181.20 0.0033
2020-08-14 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 12,444 1,130 9.99 734 36.94 0.0014
2020-05-15 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 11,314 -38,120 -77.11 536 -82.23 0.0012
2020-02-14 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 49,434 25,707 108.34 3,016 112.10 0.0052
2019-11-14 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 23,727 12,147 104.90 1,422 90.87 0.0027
2019-08-13 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 11,580 3,269 39.33 745 10.37 0.0014
2019-05-15 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 8,311 8,311 675 0.0012
2017-02-09 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -16,599 -100.00 0 -100.00
2016-08-12 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 16,599 -1,247 -6.99 387 -46.47 0.0011
2016-05-13 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 17,846 -2,079 -10.43 723 -41.41 0.0020
2016-02-12 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 19,925 -10,830 -35.21 1,234 -0.72 0.0030
2015-11-12 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 30,755 -8,643 -21.94 1,243 -45.19 0.0031
2015-08-13 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 39,398 3,044 8.37 2,268 -2.03 0.0046
2015-05-14 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 36,354 29,937 466.53 2,315 484.60 0.0044
2015-02-13 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 6,417 6,417 0.00 396 0.0008
2014-11-18 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 0 -12,108 -100.00 0 -100.00
2014-08-14 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 12,108 12,108 417 0.0009
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.