BioCryst Pharmaceuticals, Inc.
MX ˙ BMV ˙ US09058V1035
SecurityMX:BCRX / BioCryst Pharmaceuticals, Inc.
InstitutionComerica Bank
Latest Disclosed Ownership184 shares
Latest Disclosed Value $ 1,435
Comerica Bank reports 24.32% increase in ownership of BCRX / BioCryst Pharmaceuticals, Inc.

On January 29, 2026 - Comerica Bank filed a 13F-HR form disclosing ownership of 184 shares of BioCryst Pharmaceuticals, Inc. (MX:BCRX) valued at $1,435 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 14, 2025 disclosing 148 shares of BioCryst Pharmaceuticals, Inc.. This represents a change in shares of 24.32% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-01-29 2025-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 184 36 24.32 1 0.00 0.0000
2025-11-14 2025-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 148 0 0.00 1 0.00 0.0000
2025-08-14 2025-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 148 0 0.00 1 0.00 0.0000
2025-05-14 2025-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 148 0 0.00 1 0.00 0.0000
2025-02-14 2024-12-31 13F/A-1 BIOCRYST PHARMACEUTICALS COM 09058V103 148 0 0.00 1 0.00 0.0000
2025-02-14 2024-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 148 0 1 0.0000
2024-11-14 2024-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 148 -13,500 -98.92 1 -98.81 0.0000
2024-08-15 2024-06-30 13F BIOCRYST PHARMACEUTICALS COMMON 09058V103 13,648 -13,500 -49.73 84 -38.69 0.0004
2024-05-16 2024-03-31 13F BIOCRYST PHARMACEUTICALS COMMON 09058V103 27,148 54 0.20 138 -15.43 0.0006
2024-02-14 2023-12-31 13F BIOCRYST PHARMACEUTICALS COMMON 09058V103 27,094 0 0.00 162 -15.18 0.0007
2023-11-21 2023-09-30 13F BIOCRYST PHARMACEUTICALS COMMON 09058V103 27,094 27,094 192 0.0010
2023-08-22 2023-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -13,805 -100.00 0 0.0000
2023-01-26 2022-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,805 0 0.00 0 -100.00 0.0011
2022-10-28 2022-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,805 0 0.00 190 15.85 0.0016
2022-08-02 2022-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,805 305 2.26 164 17.99 0.0013
2022-04-27 2022-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,500 0 0.00 139 -29.80 0.0010
2022-02-18 2021-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,500 0 0.00 198 0.00 0.0015
2021-11-22 2021-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,500 -4,923 -26.72 198 -24.43 0.0012
2021-08-26 2021-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 18,423 -434 -2.30 262 14.41 0.0016
2021-04-28 2021-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 18,857 -664 -3.40 229 27.93 0.0014
2021-01-28 2020-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 19,521 -385 -1.93 179 141.89 0.0011
2020-10-30 2020-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 19,906 631 3.27 74 -20.43 0.0005
2020-07-31 2020-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 19,275 1,036 5.68 93 43.08 0.0007
2020-05-01 2020-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 18,239 0 0.00 65 27.45 0.0006
2020-02-07 2019-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 18,239 1,333 7.88 51 27.50 0.0004
2019-10-31 2019-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 16,906 -53 -0.31 40 -32.20 0.0003
2019-08-02 2019-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 16,959 0 0.00 59 -59.86 0.0005
2019-05-02 2019-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 16,959 0 0.00 147 0.00 0.0012
2019-02-06 2018-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 16,959 0 0.00 147 23.53 0.0012
2018-11-01 2018-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 16,959 0 0.00 119 10.19 0.0010
2018-08-01 2018-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 16,959 0 0.00 108 31.71 0.0008
2018-05-01 2018-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 16,959 0 0.00 82 -1.20 0.0006
2018-02-02 2017-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 16,959 538 3.28 83 13.70 0.0006
2017-11-06 2017-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 16,421 0 0.00 73 -14.12 0.0005
2017-08-03 2017-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 16,421 316 1.96 85 -18.27 0.0006
2017-05-03 2017-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 16,105 0 0.00 104 4.00 0.0008
2017-02-08 2016-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 16,105 2,552 18.83 100 49.25 0.0008
2016-08-11 2016-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,553 0 0.00 67 59.52 0.0006
2016-05-11 2016-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,553 0 0.00 42 -63.48 0.0004
2016-02-05 2015-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,553 -294 -2.12 115 -27.22 0.0011
2015-11-12 2015-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,847 -13,919 -50.13 158 -62.02 0.0015
2015-08-13 2015-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 27,766 13,883 100.00 416 232.80 0.0018
2015-05-15 2015-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,883 -13,883 -50.00 125 -63.02 0.0011
2015-02-13 2014-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 27,766 13,883 100.00 338 148.53 0.0015
2014-10-21 2014-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,883 -706 -4.84 136 -26.88 0.0012
2014-08-12 2014-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 14,589 1,089 8.07 186 30.07 0.0016
2014-05-15 2014-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,500 0 0.00 143 38.83 0.0011
2014-02-11 2013-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 13,500 -13,500 -50.00 103 -47.72 0.0008
2013-11-12 2013-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 27,000 -4,705 -14.84 197 302.04 0.0014
2013-08-13 2013-06-30 13F/A-1 BIOCRYST PHARMACEUTICALS COM 09058V103 31,705 31,705 49 0.0004
2013-08-08 2013-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 63,410 98
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.