AnaptysBio, Inc.
MX ˙ BMV ˙ US0327241065
SecurityMX:ANAB / AnaptysBio, Inc.
InstitutionRenaissance Technologies Llc
ManagerJames Simons
Latest Disclosed Ownership90,900 shares
Latest Disclosed Value $ 5,041,314
Renaissance Technologies Llc reports 19.13% increase in ownership of ANAB / AnaptysBio, Inc.

On May 14, 2026 - Renaissance Technologies Llc filed a 13F-HR form disclosing ownership of 90,900 shares of AnaptysBio, Inc. (MX:ANAB) valued at $5,041,314 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 76,300 shares of AnaptysBio, Inc.. This represents a change in shares of 19.13% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F ANAPTYSBIO COM 032724106 90,900 14,600 19.13 5,041 36.28 0.0079
2026-02-12 2025-12-31 13F ANAPTYSBIO COM 032724106 76,300 -47,000 -38.12 3,699 -2.01 0.0057
2025-11-13 2025-09-30 13F ANAPTYSBIO COM 032724106 123,300 -139,786 -53.13 3,775 -35.36 0.0050
2025-08-13 2025-06-30 13F ANAPTYSBIO COM 032724106 263,086 -75,614 -22.32 5,841 -7.24 0.0078
2025-05-14 2025-03-31 13F ANAPTYSBIO COM 032724106 338,700 145,500 75.31 6,296 146.23 0.0095
2025-02-13 2024-12-31 13F ANAPTYSBIO COM 032724106 193,200 -7,200 -3.59 2,558 -61.91 0.0038
2024-11-13 2024-09-30 13F ANAPTYSBIO COM 032724106 200,400 47,698 31.24 6,713 75.46 0.0101
2024-08-09 2024-06-30 13F ANAPTYSBIO COM 032724106 152,702 52,502 52.40 3,827 191,200.00 0.0065
2024-05-13 2024-03-31 13F ANAPTYSBIO COM 032724106 100,200 4,600 4.81 2 0.00 0.0035
2024-02-13 2023-12-31 13F ANAPTYSBIO COM 032724106 95,600 2,900 3.13 2 100.00 0.0032
2023-11-14 2023-09-30 13F ANAPTYSBIO COM 032724106 92,700 34,700 59.83 2 0.00 0.0028
2023-08-11 2023-06-30 13F ANAPTYSBIO COM 032724106 58,000 -13,600 -18.99 1 0.00 0.0017
2023-05-12 2023-03-31 13F ANAPTYSBIO COM 032724106 71,600 71,600 2 0.0021
2022-11-14 2022-09-30 13F ANAPTYSBIO COM 032724106 0 -29,600 -100.00 0 -100.00
2022-08-12 2022-06-30 13F ANAPTYSBIO COM 032724106 29,600 -28,700 -49.23 601 -58.32 0.0007
2022-05-13 2022-03-31 13F ANAPTYSBIO COM 032724106 58,300 23,700 68.50 1,442 19.97 0.0017
2022-02-11 2021-12-31 13F ANAPTYSBIO COM 032724106 34,600 -34,100 -49.64 1,202 -35.48 0.0015
2021-11-12 2021-09-30 13F ANAPTYSBIO COM 032724106 68,700 -155,600 -69.37 1,863 -67.97 0.0024
2021-08-13 2021-06-30 13F ANAPTYSBIO COM 032724106 224,300 -6,482 -2.81 5,816 16.95 0.0073
2021-05-13 2021-03-31 13F ANAPTYSBIO COM 032724106 230,782 96,182 71.46 4,973 71.84 0.0062
2021-02-10 2020-12-31 13F ANAPTYSBIO COM 032724106 134,600 107,800 402.24 2,894 632.66 0.0031
2020-11-13 2020-09-30 13F ANAPTYSBIO COM 032724106 26,800 26,800 -80.09 395 -86.35 0.0004
2020-08-13 2020-06-30 13F ANAPTYSBIO COM 032724106 0 -293,500 -100.00 0 -100.00
2020-05-14 2020-03-31 13F ANAPTYSBIO COM 032724106 293,500 201,100 217.64 4,147 176.10 0.0040
2020-02-13 2019-12-31 13F ANAPTYSBIO COM 032724106 92,400 92,400 1,502 0.0012
2018-11-13 2018-09-30 13F ANAPTYSBIO COM 032724106 0 -59,400 -100.00 0 -100.00
2018-08-13 2018-06-30 13F ANAPTYSBIO COM 032724106 59,400 0 0.00 6,182 0.00 0.0068
2018-05-14 2018-03-31 13F ANAPTYSBIO COM 032724106 59,400 -68,100 -53.41 6,182 -51.86 0.0068
2018-02-13 2017-12-31 13F ANAPTYSBIO COM 032724106 127,500 29,700 30.37 12,842 275.72 0.0142
2017-11-13 2017-09-30 13F ANAPTYSBIO COM 032724106 97,800 97,800 3,418 0.0040
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.