Agios Pharmaceuticals, Inc.
MX ˙ BMV ˙ US00847X1046
SecurityMX:AGIO / Agios Pharmaceuticals, Inc.
InstitutionProfund Advisors Llc
Latest Disclosed Ownership45,794 shares
Latest Disclosed Value $ 1,549,211
Profund Advisors Llc reports 14.92% increase in ownership of AGIO / Agios Pharmaceuticals, Inc.

On April 24, 2026 - Profund Advisors Llc filed a 13F-HR form disclosing ownership of 45,794 shares of Agios Pharmaceuticals, Inc. (MX:AGIO) valued at $1,549,211 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 6, 2026 disclosing 39,850 shares of Agios Pharmaceuticals, Inc.. This represents a change in shares of 14.92% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-24 2026-03-31 13F AGIOS PHARMACEUTICALS COM 00847X104 45,794 5,944 14.92 1,549 42.90 0.0569
2026-02-06 2025-12-31 13F AGIOS PHARMACEUTICALS COM 00847X104 39,850 24,741 163.75 1,085 78.88 0.0330
2025-11-06 2025-09-30 13F AGIOS PHARMACEUTICALS COM 00847X104 15,109 4,258 39.24 606 68.33 0.0197
2025-08-07 2025-06-30 13F AGIOS PHARMACEUTICALS COM 00847X104 10,851 -8,731 -44.59 361 -37.17 0.0130
2025-05-08 2025-03-31 13F AGIOS PHARMACEUTICALS COM 00847X104 19,582 5,405 38.13 574 23.23 0.0249
2025-02-14 2024-12-31 13F AGIOS PHARMACEUTICALS COM 00847X104 14,177 -3,934 -21.72 466 -42.16 0.0170
2024-11-14 2024-09-30 13F AGIOS PHARMACEUTICALS COM 00847X104 18,111 3,338 22.60 805 26.22 0.0304
2024-08-13 2024-06-30 13F AGIOS PHARMACEUTICALS COM 00847X104 14,773 -19,941 -57.44 637 -37.24 0.0236
2024-05-08 2024-03-31 13F AGIOS PHARMACEUTICALS COM 00847X104 34,714 9,156 35.82 1,015 78.38 0.0395
2024-02-14 2023-12-31 13F AGIOS PHARMACEUTICALS COM 00847X104 25,558 2,442 10.56 569 -0.52 0.0244
2023-11-13 2023-09-30 13F AGIOS PHARMACEUTICALS COM 00847X104 23,116 -7,028 -23.31 572 -32.94 0.0316
2023-08-10 2023-06-30 13F AGIOS PHARMACEUTICALS COM 00847X104 30,144 -8,380 -21.75 854 -3.51 0.0458
2023-05-12 2023-03-31 13F AGIOS PHARMACEUTICALS COM 00847X104 38,524 38,524 885 0.0547
2022-07-30 2022-06-30 13F AGIOS PHARMACEUTICALS COM 00847X104 0 -8,372 -100.00 0 -100.00
2022-05-10 2022-03-31 13F AGIOS PHARMACEUTICALS COM 00847X104 8,372 -935 -10.05 244 -20.26 0.0102
2022-02-08 2021-12-31 13F AGIOS PHARMACEUTICALS COM 00847X104 9,307 -1,982 -17.56 306 -41.27 0.0100
2021-11-12 2021-09-30 13F AGIOS PHARMACEUTICALS COM 00847X104 11,289 756 7.18 521 -10.17 0.0176
2021-08-12 2021-06-30 13F AGIOS PHARMACEUTICALS COM 00847X104 10,533 356 3.50 580 10.27 0.0195
2021-05-14 2021-03-31 13F AGIOS PHARMACEUTICALS COM 00847X104 10,177 -1,536 -13.11 526 3.54 0.0202
2021-02-09 2020-12-31 13F AGIOS PHARMACEUTICALS COM 00847X104 11,713 1,048 9.83 508 36.19 0.0222
2020-11-13 2020-09-30 13F AGIOS PHARMACEUTICALS COM 00847X104 10,665 -2,769 -20.61 373 -48.05 0.0192
2020-08-03 2020-06-30 13F AGIOS PHARMACEUTICALS COM 00847X104 13,434 2,335 21.04 718 82.23 0.0400
2020-05-15 2020-03-31 13F AGIOS PHARMACEUTICALS COM 00847X104 11,099 -4,049 -26.73 394 -45.50 0.0296
2020-02-18 2019-12-31 13F AGIOS PHARMACEUTICALS COM 00847X104 15,148 3,249 27.30 723 87.31 0.0315
2019-11-12 2019-09-30 13F AGIOS PHARMACEUTICALS COM 00847X104 11,899 -684 -5.44 386 -38.54 0.0195
2019-08-13 2019-06-30 13F AGIOS PHARMACEUTICALS COM 00847X104 12,583 -1,572 -11.11 628 -34.24 0.0298
2019-05-15 2019-03-31 13F AGIOS PHARMACEUTICALS COM 00847X104 14,155 264 1.90 955 48.99 0.0459
2019-02-14 2018-12-31 13F AGIOS PHARMACEUTICALS COM 00847X104 13,891 -3,350 -19.43 641 -51.80 0.0396
2018-11-13 2018-09-30 13F AGIOS PHARMACEUTICALS COM 00847X104 17,241 1,853 12.04 1,330 2.62 0.0505
2018-08-13 2018-06-30 13F AGIOS PHARMACEUTICALS COM 00847X104 15,388 -487 -3.07 1,296 -0.15 0.0518
2018-05-14 2018-03-31 13F AGIOS PHARMACEUTICALS COM 00847X104 15,875 649 4.26 1,298 49.20 0.0517
2018-02-14 2017-12-31 13F AGIOS PHARMACEUTICALS COM 00847X104 15,226 -1,956 -11.38 870 -24.15 0.0335
2017-11-13 2017-09-30 13F AGIOS PHARMACEUTICALS COM 00847X104 17,182 1,211 7.58 1,147 39.54 0.0477
2017-08-11 2017-06-30 13F AGIOS PHARMACEUTICALS COM 00847X104 15,971 2,558 19.07 822 4.98 0.0372
2017-04-25 2017-03-31 13F AGIOS PHARMACEUTICALS COM 00847X104 13,413 -1,030 -7.13 783 29.85 0.0350
2017-02-13 2016-12-31 13F AGIOS PHARMACEUTICALS COM 00847X104 14,443 -2,137 -12.89 603 -31.16 0.0278
2016-11-10 2016-09-30 13F AGIOS PHARMACEUTICALS COM 00847X104 16,580 2,199 15.29 876 45.51 0.0417
2016-08-12 2016-06-30 13F AGIOS PHARMACEUTICALS COM 00847X104 14,381 -479 -3.22 602 -0.17 0.0293
2016-05-06 2016-03-31 13F AGIOS PHARMACEUTICALS COM 00847X104 14,860 -3,631 -19.64 603 -49.75 0.0313
2016-02-05 2015-12-31 13F AGIOS PHARMACEUTICALS COM 00847X104 18,491 37 0.20 1,200 -7.90 0.0569
2015-11-06 2015-09-30 13F AGIOS PHARMACEUTICALS COM 00847X104 18,454 18,454 1,303 0.0743
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.