Ionis Pharmaceuticals, Inc.
GB ˙ LSE ˙ US4622221004
74,21 $ ↓ -1,19 (-1,58%)
2026-06-05
DEL PRIS
SecurityGB:0JDI / Ionis Pharmaceuticals, Inc.
InstitutionState Street Corp
Latest Disclosed Ownership3,995,564 shares
Latest Disclosed Value $ 300,026,901
State Street Corp reports 0.52% increase in ownership of 0JDI / Ionis Pharmaceuticals, Inc.

On May 15, 2026 - State Street Corp filed a 13F-HR form disclosing ownership of 3,995,564 shares of Ionis Pharmaceuticals, Inc. (GB:0JDI) valued at $300,458,422 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 3,974,865 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 0.52% during the quarter. The current value of the position is $296,510,804 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 3,995,564 20,699 0.52 300,027 -4.59 0.0104
2026-02-13 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 3,974,865 -413,786 -9.43 314,452 9.52 0.0105
2025-11-14 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 4,388,651 -141,747 -3.13 287,106 60.40 0.0100
2025-08-14 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 4,530,398 -314,735 -6.50 178,996 22.45 0.0067
2025-05-15 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 4,845,133 -581,280 -10.71 146,178 -22.95 0.0060
2025-02-14 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 5,426,413 576,276 11.88 189,707 -2.36 0.0075
2024-11-14 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 4,850,137 659,632 15.74 194,296 -2.72 0.0079
2024-08-14 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 4,190,505 34,841 0.84 199,719 10.86 0.0087
2024-05-15 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 4,155,664 146,867 3.66 180,148 -11.17 0.0081
2024-02-14 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 4,008,797 53,768 1.36 202,805 13.05 0.0099
2023-11-14 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 3,955,029 -19,424 -0.49 179,400 10.01 0.0099
2023-08-14 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 3,974,453 -93,881 -2.31 163,072 12.15 0.0086
2023-05-15 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 4,068,334 -150,395 -3.56 145,400 -8.75 0.0082
2023-05-15 2022-12-31 13F/A-99 IONIS PHARMACEUTICALS COM 462222100 4,218,729 457,774 12.17 159,341 -4.21 0.0094
2023-05-15 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 4,218,729 457,774 159,341 0.0094
2022-11-15 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 3,760,955 -441,919 -10.51 166,347 6.91 0.0105
2022-08-15 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 4,202,874 172,228 4.27 155,590 4.22 0.0093
2022-05-16 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 4,030,646 124,271 3.18 149,295 25.59 0.0074
2022-02-14 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 3,906,375 385,061 10.94 118,871 0.65 0.0056
2021-11-15 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 3,521,314 290,363 8.99 118,105 -8.36 0.0062
2021-08-16 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 3,230,951 -178,620 -5.24 128,883 -15.92 0.0068
2021-07-09 2021-03-31 13F/A-1 ISIS PHARMACEUTICALS INC DEL COM 462222100 3,409,571 -503,757 -12.87 153,294 -30.72 0.0088
2021-05-17 2021-03-31 13F ISIS PHARMACEUTICALS INC DEL COM 462222100 3,409,571 -503,757 153,294 0.0088
2021-02-16 2020-12-31 13F ISIS PHARMACEUTICALS INC DEL COM 462222100 3,913,328 358,434 10.08 221,260 31.17 0.0135
2020-11-10 2020-09-30 13F ISIS PHARMACEUTICALS INC DEL COM 462222100 3,554,894 -35,529 -0.99 168,680 -20.32 0.0115
2020-08-14 2020-06-30 13F ISIS PHARMACEUTICALS INC DEL COM 462222100 3,590,423 -302,471 -7.77 211,691 15.01 0.0154
2020-06-19 2020-03-31 13F/A-1 ISIS PHARMACEUTICALS INC DEL COM 462222100 3,892,894 45,509 1.18 184,056 -20.81 0.0161
2020-05-11 2020-03-31 13F ISIS PHARMACEUTICALS INC DEL COM 462222100 3,892,894 45,509 184,056 16,163.8228
2020-02-06 2019-12-31 13F ISIS PHARMACEUTICALS INC DEL COM 462222100 3,847,385 196,602 5.39 232,421 6.27 0.0159
2019-11-14 2019-09-30 13F ISIS PHARMACEUTICALS INC DEL COM 462222100 3,650,783 65,104 1.82 218,718 -5.09 0.0163
2019-08-14 2019-06-30 13F ISIS PHARMACEUTICALS INC DEL COM 462222100 3,585,679 1,032,591 40.44 230,452 11.20 0.0172
2019-05-15 2019-03-31 13F ISIS PHARMACEUTICALS INC DEL COM 462222100 2,553,088 17,919 0.71 207,234 51.21 0.0162
2019-02-12 2018-12-31 13F ISIS PHARMACEUTICALS INC DEL COM 462222100 2,535,169 -479,547 -15.91 137,051 -11.86 0.0125
2018-11-09 2018-09-30 13F IONIS PHARMACEUTICALS Common equity shares 462222100 3,014,716 -44,302 -1.45 155,501 21.99 0.0119
2018-08-14 2018-06-30 13F IONIS PHARMACEUTICALS Common equity shares 462222100 3,059,018 93,771 3.16 127,470 -2.47 0.0107
2018-05-15 2018-03-31 13F IONIS PHARMACEUTICALS Common equity shares 462222100 2,965,247 212,705 7.73 130,701 -5.60 0.0111
2018-02-14 2017-12-31 13F IONIS PHARMACEUTICALS Common equity shares 462222100 2,752,542 -189,279 -6.43 138,454 -7.17 0.0111
2017-11-14 2017-09-30 13F IONIS PHARMACEUTICALS Common equity shares 462222100 2,941,821 -22,169 -0.75 149,153 -1.08 0.0129
2017-08-14 2017-06-30 13F IONIS PHARMACEUTICALS Common equity shares 462222100 2,963,990 -376,481 -11.27 150,779 12.28 0.0133
2017-05-15 2017-03-31 13F IONIS PHARMACEUTICALS Common equity shares 462222100 3,340,471 567,792 20.48 134,285 1.26 0.0120
2017-02-09 2016-12-31 13F IONIS PHARMACEUTICALS Common equity shares 462222100 2,772,679 -811,925 -22.65 132,612 0.97 0.0125
2017-01-13 2016-09-30 13F/A-1 IONIS PHARMACEUTICALS Common equity shares 462222100 3,584,604 -662,307 -15.60 131,339 32.78 0.0132
2016-11-14 2016-09-30 13F IONIS PHARMACEUTICALS Common equity shares 462222100 3,584,604 131,339
2016-08-12 2016-06-30 13F IONIS PHARMACEUTICALS Common equity shares 462222100 4,246,911 1,209,523 39.82 98,915 -19.59 0.0106
2016-05-20 2016-03-31 13F/A-1 IONIS PHARMACEUTICALS Common equity shares 462222100 3,037,388 412,515 15.72 123,010 -24.33 0.0133
2016-05-12 2016-03-31 13F IONIS PHARMACEUTICALS Common equity shares 462222100 3,037,388 123,010
2016-02-16 2015-12-31 13F IONIS PHARMACEUTICALS Common equity shares 462222100 2,624,873 126,047 5.04 162,557 60.95 0.0178
2015-11-16 2015-09-30 13F ISIS PHARMACEUTICALS Common equity shares 464330109 2,498,826 -2,005 -0.08 100,996 -29.83 0.0118
2015-08-13 2015-06-30 13F ISIS PHARMACEUTICALS Common equity shares 464330109 2,500,831 -670,000 -21.13 143,929 -28.71 0.0154
2015-05-15 2015-03-31 13F ISIS PHARMACEUTICALS Common equity shares 464330109 3,170,831 590,384 22.88 201,885 26.72 0.0207
2015-02-11 2014-12-31 13F ISIS PHARMACEUTICALS Common equity shares 464330109 2,580,447 -96,105 -3.59 159,317 53.29 0.0159
2014-11-12 2014-09-30 13F/A-1 ISIS PHARMACEUTICALS Common equity shares 464330109 2,676,552 268,934 11.17 103,933 25.31 0.0112
2014-11-10 2014-09-30 13F ISIS PHARMACEUTICALS Common equity shares 464330109 2,676,552 103,933
2014-08-12 2014-06-30 13F ISIS PHARMACEUTICALS Common equity shares 464330109 2,407,618 -215 -0.01 82,941 -20.28 0.0090
2014-05-15 2014-03-31 13F/A-1 ISIS PHARMACEUTICALS Common equity shares 464330109 2,407,833 13,556 0.57 104,042 9.07 0.0118
2014-05-13 2014-03-31 13F ISIS PHARMACEUTICALS Common equity shares 464330109 2,408,878 104,087
2014-02-06 2013-12-31 13F/A-1 ISIS PHARMACEUTICALS Common equity shares 464330109 2,394,277 -251,984 -9.52 95,394 -3.98 0.0106
2014-02-06 2013-12-31 13F ISIS PHARMACEUTICALS Common equity shares 464330109 3,492,291 36,528
2013-11-12 2013-09-30 13F ISIS PHARMACEUTICALS Common Stock 464330109 2,646,261 -64,158 -2.37 99,345 36.41 0.0122
2013-08-08 2013-06-30 13F ISIS PHARMACEUTICALS Common Stock 464330109 2,710,419 2,710,419 72,830 0.0095
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.