Ionis Pharmaceuticals, Inc.
GB ˙ LSE ˙ US4622221004
74,21 $ ↓ -1,19 (-1,58%)
2026-06-05
DEL PRIS
SecurityGB:0JDI / Ionis Pharmaceuticals, Inc.
InstitutionNorges Bank
Latest Disclosed Ownership320,160 shares
Latest Disclosed Value $ 25,327,858
Norges Bank ownership in 0JDI / Ionis Pharmaceuticals, Inc.

On February 10, 2026 - Norges Bank filed a 13F-HR form disclosing ownership of 320,160 shares of Ionis Pharmaceuticals, Inc. (GB:0JDI) valued at $25,443,339 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 13, 2025 disclosing 0 shares of Ionis Pharmaceuticals, Inc.. The current value of the position is $23,759,074 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-10 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 320,160 320,160 25,328 0.0027
2025-11-13 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 0 -450,254 -100.00 0 -100.00
2025-08-13 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 450,254 -407,974 -47.54 17,790 -31.30 0.0022
2026-05-11 2025-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 858,228 -856,534 -49.95 25,893 -56.81 0.0036
2025-02-12 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,714,762 -312,399 -15.41 59,948 -26.18 0.0079
2025-11-12 2024-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 2,027,161 1,007,820 98.87 81,208 67.16 0.0113
2024-08-14 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,019,341 -217,657 -17.60 48,582 -9.40 0.0073
2025-05-14 2024-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,236,998 65,062 5.55 53,624 -9.56 0.0085
2024-02-09 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,171,936 18,010 1.56 59,288 13.27 0.0104
2024-11-13 2023-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,153,926 141,308 13.95 52,342 25.98 0.0106
2024-08-14 2023-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,012,618 -120,073 -10.60 41,548 2.63 0.0082
2024-05-15 2023-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,132,691 -163,956 -12.64 40,482 -17.34 0.0089
2023-02-14 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,296,647 105,896 8.89 48,974 -7.01 0.0118
2023-11-13 2022-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,190,751 72,410 6.47 52,667 27.21 0.0140
2023-08-14 2022-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,118,341 332,780 42.36 41,401 42.28 0.0107
2023-05-12 2022-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 785,561 -45,658 -5.49 29,097 15.04 0.0063
2022-03-09 2021-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 831,219 -315,699 -27.53 25,294 -34.25 0.0052
2022-11-14 2021-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,146,918 250,629 27.96 38,468 7.59 0.0085
2022-08-15 2021-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 896,289 88,801 11.00 35,753 -1.52 0.0078
2022-05-09 2021-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 807,488 47,063 6.19 36,305 -15.56 0.0083
2021-03-02 2020-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 760,425 -103,291 -11.96 42,994 4.91 0.0100
2021-11-12 2020-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 863,716 -22,429 -2.53 40,983 -21.56 0.0109
2021-08-13 2020-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 886,145 -179,492 -16.84 52,247 3.70 0.0150
2021-05-07 2020-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,065,637 -143,350 -11.86 50,383 -31.02 0.0180
2020-03-03 2019-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,208,987 -186,410 -13.36 73,035 -12.64 0.0204
2020-11-13 2019-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,395,397 46,635 3.46 83,599 -3.56 0.0256
2020-08-13 2019-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,348,762 5,986 0.45 86,685 -20.47 0.0268
2020-05-11 2019-03-31 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 1,342,776 335,332 33.29 108,994 100.12 0.0352
2019-03-04 2018-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,007,444 -195,645 -16.26 54,463 -12.23 0.0203
2019-12-02 2018-09-30 13F/A-3 IONIS PHARMACEUTICALS COM 462222100 1,203,089 399,751 49.76 62,055 85.38 0.0202
2019-12-02 2018-09-30 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 1,203,089 399,751 62,055 0.0202
2019-11-12 2018-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,203,089 399,751 62,055 0.0202
2019-08-12 2018-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 803,338 0 0.00 33,475 -5.46 0.0115
2019-05-15 2018-03-31 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 803,338 4,967 0.62 35,410 -11.82 0.0128
2018-03-05 2017-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 798,371 -189,755 -19.20 40,158 -19.84 0.0144
2018-11-13 2017-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 988,126 310,000 45.71 50,098 45.23 0.0190
2018-07-24 2017-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 678,126 -37,230 -5.20 34,496 19.96 0.0137
2018-05-11 2017-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 715,356 -350,410 -32.88 28,757 -43.59 0.0118
2017-03-02 2016-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,065,766 193,972 22.25 50,976 67.09 0.0223
2017-11-13 2016-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 871,794 -64,887 -6.93 30,508 39.85 0.0144
2017-08-09 2016-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 936,681 -82,555 -8.10 21,815 -47.15 0.0104
2017-05-10 2016-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,019,236 0 0.00 41,279 -34.60 0.0203
2016-04-18 2015-12-31 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 1,019,236 0 0.00 63,121 53.22 0.0314
2016-03-16 2015-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,019,236 0 63,121 0.0317
2016-11-14 2015-09-30 13F/A-2 ISIS PHARMACEUTICALS COM 464330109 1,019,236 -40,344 -3.81 41,197 -32.44 0.0216
2016-08-12 2015-06-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 1,059,580 104,384 10.93 60,979 0.26 0.0305
2016-05-13 2015-03-31 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 955,196 74,870 8.50 60,818 11.90 0.0298
2015-03-19 2014-12-31 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 880,326 128,249 54,351 0.0277
2016-04-18 2014-12-31 13F/A-2 ISIS PHARMACEUTICALS COM 464330109 880,326 128,249 17.05 54,351 86.11 0.0276
2015-11-12 2014-09-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 752,077 0 0.00 29,203 12.71 0.0158
2015-08-10 2014-06-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 752,077 0 0.00 25,909 -20.27 0.0140
2015-05-12 2014-03-31 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 752,077 0 0.00 32,497 8.46 0.0183
2014-03-07 2013-12-31 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 752,077 25,595 29,962 0.0183
2014-03-20 2013-12-31 13F/A-2 ISIS PHARMACEUTICALS COM 464330109 752,077 0 29,962 0.0176
2014-05-12 2013-12-31 13F/A-3 ISIS PHARMACEUTICALS COM 464330109 752,077 25,595 3.52 29,962 9.86 0.0173
2014-11-14 2013-09-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 726,482 243,186 50.32 27,273 110.00 0.0159
2014-08-14 2013-06-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 483,296 -78,718 -14.01 12,987 36.42 0.0081
2014-04-04 2013-03-31 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 562,014 178,404 9,520 0.0063
2014-05-12 2013-03-31 13F/A-2 ISIS PHARMACEUTICALS COM 464330109 562,014 178,404 46.51 9,520 76.39 0.0062
2013-11-14 2012-09-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 383,610 0 0.00 5,397 16.09 0.0036
2013-08-15 2012-06-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 383,610 383,610 4,649 0.0037
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.