Ionis Pharmaceuticals, Inc.
GB ˙ LSE ˙ US4622221004
75,40 $ ↑1,57 (2,13%)
2026-06-04
DEL PRIS
SecurityGB:0JDI / Ionis Pharmaceuticals, Inc.
InstitutionInvesco Ltd.
Latest Disclosed Ownership1,277,358 shares
Latest Disclosed Value $ 95,916,812
Invesco Ltd. reports 0.64% increase in ownership of 0JDI / Ionis Pharmaceuticals, Inc.

On May 12, 2026 - Invesco Ltd. filed a 13F-HR form disclosing ownership of 1,277,358 shares of Ionis Pharmaceuticals, Inc. (GB:0JDI) valued at $96,054,767 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 19, 2026 disclosing 1,269,290 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 0.64% during the quarter. The current value of the position is $96,312,793 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-12 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,277,358 8,068 0.64 95,917 -4.48 0.0018
2026-02-19 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,269,290 750,220 144.53 100,414 195.71 0.0154
2025-11-13 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 519,070 262,835 102.58 33,958 235.44 0.0053
2025-08-13 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 256,235 -618,599 -70.71 10,124 -61.65 0.0017
2025-05-12 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 874,834 86,235 10.94 26,394 -4.27 0.0050
2025-02-13 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 788,599 -21,702 -2.68 27,569 -15.07 0.0051
2024-11-12 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 810,301 -158,616 -16.37 32,461 -29.71 0.0063
2024-08-13 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 968,917 526,030 118.77 46,179 140.52 0.0098
2024-05-14 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 442,887 236,986 115.10 19,199 84.32 0.0041
2024-02-13 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 205,901 74,734 56.98 10,417 75.09 0.0025
2023-11-13 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 131,167 1,449 1.12 5,950 11.78 0.0016
2023-08-11 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 129,718 -186,002 -58.91 5,322 -52.83 0.0014
2023-05-12 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 315,720 -6,727 -2.09 11,284 -7.35 0.0031
2023-02-13 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 322,447 27,248 9.23 12,179 -6.74 0.0036
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 295,199 -30,786 -9.44 13,058 8.19 0.0042
2022-08-15 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 325,985 185,993 132.86 12,069 132.77 0.0037
2022-05-16 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 139,992 7,750 5.86 5,185 28.85 0.0013
2022-02-14 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 132,242 -9,113 -6.45 4,024 -15.14 0.0010
2021-11-15 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 141,355 -199,258 -58.50 4,742 -65.10 0.0012
2021-08-17 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 340,613 -2,018,821 -85.56 13,588 -87.19 0.0033
2021-05-17 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 2,359,434 -1,025,435 -30.29 106,080 -44.57 0.0283
2021-02-16 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 3,384,869 813,228 31.62 191,382 56.84 0.0557
2020-11-16 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 2,571,641 231,896 9.91 122,024 -11.55 0.0412
2020-08-14 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 2,339,745 -1,052 -0.04 137,951 24.65 0.0493
2020-05-15 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 2,340,797 -14,229 -0.60 110,673 -22.21 0.0466
2020-02-14 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 2,355,026 -21,637 -0.91 142,267 -0.08 0.0442
2019-11-14 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 2,376,663 105,124 4.63 142,387 -2.47 0.0372
2019-08-14 2019-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 2,271,539 2,191,974 2,754.95 145,992 2,160.64 0.0376
2019-08-14 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 2,271,539 1,968,135 145,992
2019-05-15 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 79,565 29,583 59.19 6,458 139.01 0.0022
2019-02-14 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 49,982 -196,208 -79.70 2,702 -78.72 0.0010
2018-11-14 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 246,190 43,172 21.27 12,698 50.09 0.0040
2018-08-14 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 203,018 385 0.19 8,460 -5.28 0.0028
2018-05-15 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 202,633 -18,873 -8.52 8,932 -19.83 0.0033
2018-02-14 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 221,506 90,061 68.52 11,142 67.20 0.0040
2017-11-14 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 131,445 -195,231 -59.76 6,664 -59.90 0.0025
2017-08-14 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 326,676 103,539 46.40 16,618 85.26 0.0052
2017-05-15 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 223,137 40,638 22.27 8,970 2.76 0.0029
2017-02-14 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 182,499 -71,049 -28.02 8,729 -6.04 0.0029
2016-11-14 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 253,548 -94,387 -27.13 9,290 14.63 0.0032
2016-08-15 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 347,935 -306,940 -46.87 8,104 -69.45 0.0030
2016-05-16 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 654,875 507,185 343.41 26,523 190.00 0.0108
2016-02-16 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 147,690 -142,559 -49.12 9,146 -22.05 0.0036
2015-11-16 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 290,249 -31,807 -9.88 11,733 -36.69 0.0050
2015-08-14 2015-06-30 13F ISIS PHARMACEUTICALS COMMON 464330109 322,056 -191,905 -37.34 18,534 -43.36 0.0073
2015-05-15 2015-03-31 13F ISIS PHARMACEUTICALS COMMON 464330109 513,961 184,643 56.07 32,724 60.95 0.0127
2015-02-13 2014-12-31 13F ISIS PHARMACEUTICALS COMMON 464330109 329,318 9,400 2.94 20,332 63.68 0.0079
2014-11-14 2014-09-30 13F ISIS PHARMACEUTICALS COMMON 464330109 319,918 -56,026 -14.90 12,422 -4.08 0.0050
2014-08-14 2014-06-30 13F ISIS PHARMACEUTICALS COMMON 464330109 375,944 -31,554 -7.74 12,951 -26.45 0.0051
2014-05-15 2014-03-31 13F ISIS PHARMACEUTICALS COMMON 464330109 407,498 33,462 8.95 17,608 18.16 0.0071
2014-02-13 2013-12-31 13F ISIS PHARMACEUTICALS COMMON 464330109 374,036 13,003 3.60 14,902 9.95 0.0059
2013-11-13 2013-09-30 13F ISIS PHARMACEUTICALS COMMON 464330109 361,033 34,611 10.60 13,554 54.53 0.0059
2013-08-14 2013-06-30 13F ISIS PHARMACEUTICALS COMMON 464330109 326,422 326,422 8,771 0.0041
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.