Ionis Pharmaceuticals, Inc.
GB ˙ LSE ˙ US4622221004
75,40 $ ↑1,57 (2,13%)
2026-06-04
DEL PRIS
SecurityGB:0JDI / Ionis Pharmaceuticals, Inc.
InstitutionAlliancebernstein L.p.
Latest Disclosed Ownership400,669 shares
Latest Disclosed Value $ 31,696,925
Alliancebernstein L.p. reports 17.21% increase in ownership of 0JDI / Ionis Pharmaceuticals, Inc.

On May 15, 2026 - Alliancebernstein L.p. filed a 13F-HR form disclosing ownership of 400,669 shares of Ionis Pharmaceuticals, Inc. (GB:0JDI) valued at $30,129,507 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 341,849 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 17.21% during the quarter. The current value of the position is $30,210,443 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 400,669 58,820 17.21 31,697 17.21 0.0086
2026-02-17 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 341,849 287,587 530.00 27,044 661.99 0.0085
2025-11-14 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 54,262 2,205 4.24 3,550 72.62 0.0011
2025-08-14 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 52,057 -48,692 -48.33 2,057 -32.35 0.0007
2025-05-15 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 100,749 48,613 93.24 3,040 66.79 0.0011
2025-02-12 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 52,136 -26 -0.05 1,823 -12.78 0.0006
2024-11-14 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 52,162 894 1.74 2,090 -14.49 0.0007
2024-08-14 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 51,268 -139,887 -73.18 2,443 -70.52 0.0009
2024-05-14 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 191,155 -66,165 -25.71 8,287 -36.34 0.0029
2024-02-14 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 257,320 -47,198 -15.50 13,018 -5.76 0.0050
2023-11-14 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 304,518 -42,020 -12.13 13,813 -2.86 0.0059
2023-08-15 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 346,538 297,938 613.04 14,218 719.01 0.0058
2023-05-15 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 48,600 -9,904 -16.93 1,737 -21.41 0.0007
2023-02-15 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 58,504 402 0.69 2,210 -14.05 0.0010
2022-11-15 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 58,102 -2,758 -4.53 2,570 14.07 0.0012
2022-08-15 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 60,860 -1,079 -1.74 2,253 -1.79 0.0010
2022-05-13 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 61,939 -41,275 -39.99 2,294 -26.97 0.0009
2022-02-14 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 103,214 34,763 50.79 3,141 36.80 0.0011
2021-11-10 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 68,451 -1,352 -1.94 2,296 -17.53 0.0009
2021-07-30 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 69,803 -7,497 -9.70 2,784 -19.88 0.0011
2021-05-06 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 77,300 8,231 11.92 3,475 -11.01 0.0015
2021-02-08 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 69,069 -600 -0.86 3,905 18.12 0.0018
2020-11-12 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 69,669 80 0.11 3,306 -19.42 0.0018
2020-08-13 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 69,589 631 0.92 4,103 25.86 0.0024
2020-05-14 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 68,958 -434 -0.63 3,260 -22.23 0.0023
2020-02-18 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 69,392 808 1.18 4,192 2.02 0.0024
2019-11-14 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 68,584 -17 -0.02 4,109 -6.80 0.0026
2019-08-14 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 68,601 1,084 1.61 4,409 -19.54 0.0027
2019-05-14 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 67,517 -4,091 -5.71 5,480 41.57 0.0036
2019-02-13 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 71,608 -645 -0.89 3,871 3.86 0.0029
2018-11-08 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 72,253 -1,537 -2.08 3,727 21.20 0.0024
2018-08-13 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 73,790 -57,697 -43.88 3,075 -46.95 0.0021
2018-05-14 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 131,487 58,850 81.02 5,796 58.62 0.0042
2018-02-13 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 72,637 -600 -0.82 3,654 -1.59 0.0026
2017-11-13 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 73,237 -50 -0.07 3,713 -0.40 0.0028
2017-08-10 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 73,287 1,708 2.39 3,728 29.58 0.0029
2017-05-11 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 71,579 -138 -0.19 2,877 -16.12 0.0023
2017-02-13 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 71,717 -3,502 -4.66 3,430 24.46 0.0029
2016-11-10 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 75,219 -19,415 -20.52 2,756 25.05 0.0023
2016-08-11 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 94,634 9,060 10.59 2,204 -36.41 0.0019
2016-05-13 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 85,574 8,652 11.25 3,466 -27.25 0.0029
2016-02-16 2015-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 76,922 -883,030 -91.99 4,764 -87.72 0.0041
2016-02-12 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 76,922 4,764
2015-11-13 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 959,952 161,994 20.30 38,801 -15.51 0.0333
2015-08-14 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 797,958 -252,700 -24.05 45,922 -31.35 0.0379
2015-05-13 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 1,050,658 136,116 14.88 66,895 18.47 0.0542
2015-02-13 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 914,542 -55,225 -5.69 56,464 49.95 0.0469
2014-11-13 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 969,767 -137,760 -12.44 37,656 -1.31 0.0317
2014-08-13 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 1,107,527 -33,326 -2.92 38,154 -22.60 0.0322
2014-05-13 2014-03-31 13F ISIS PHARMACEUTICALS COM 464330109 1,140,853 25,076 2.25 49,296 10.89 0.0426
2014-02-13 2013-12-31 13F ISIS PHARMACEUTICALS COM 464330109 1,115,777 -356,777 -24.23 44,453 -19.59 0.0397
2013-11-14 2013-09-30 13F ISIS PHARMACEUTICALS COM 464330109 1,472,554 26,191 1.81 55,280 42.24 0.0546
2013-08-13 2013-06-30 13F ISIS PHARMACEUTICALS COM 464330109 1,446,363 1,446,363 38,864 0.0413
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.