Madrigal Pharmaceuticals, Inc.
DE ˙ DB ˙ US5588681057
426,20 € ↑6,40 (1,52%)
2026-06-04
DEL PRIS
SecurityDE:YDO1 / Madrigal Pharmaceuticals, Inc.
InstitutionRenaissance Technologies Llc
ManagerJames Simons
Latest Disclosed Ownership71,870 shares
Latest Disclosed Value $ 37,621,789
Renaissance Technologies Llc reports 14.30% decrease in ownership of YDO1 / Madrigal Pharmaceuticals, Inc.

On May 14, 2026 - Renaissance Technologies Llc filed a 13F-HR form disclosing ownership of 71,870 shares of Madrigal Pharmaceuticals, Inc. (DE:YDO1) valued at $32,363,061 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 83,862 shares of Madrigal Pharmaceuticals, Inc.. This represents a change in shares of -14.30% during the quarter. The current value of the position is $30,630,994 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 71,870 -11,992 -14.30 37,622 -22.96 0.0588
2026-02-12 2025-12-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 83,862 -36,820 -30.51 48,836 -11.77 0.0758
2025-11-13 2025-09-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 120,682 109,846 1,013.71 55,352 1,588.08 0.0731
2025-08-13 2025-06-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 10,836 -74,250 -87.26 3,279 -88.37 0.0044
2025-05-14 2025-03-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 85,086 -75,696 -47.08 28,183 -43.19 0.0427
2025-02-13 2024-12-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 160,782 116,285 261.33 49,613 425.38 0.0734
2024-11-13 2024-09-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 44,497 44,497 9,443 0.0142
2024-02-13 2023-12-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 0 -68,082 -100.00 0 -100.00
2023-11-14 2023-09-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 68,082 -10,600 -13.47 10 -50.00 0.0170
2023-08-11 2023-06-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 78,682 -96,700 -55.14 18 -57.14 0.0262
2023-05-12 2023-03-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 175,382 170,800 3,727.63 42 4,100.00 0.0564
2023-02-13 2022-12-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 4,582 4,582 1 0.0018
2022-08-12 2022-06-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 0 -4,800 -100.00 0 -100.00
2022-05-13 2022-03-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 4,800 2,400 100.00 471 132.02 0.0006
2022-02-11 2021-12-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 2,400 -14,711 -85.97 203 -85.13 0.0003
2021-11-12 2021-09-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 17,111 -35,871 -67.70 1,365 -73.55 0.0018
2021-08-13 2021-06-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 52,982 18,700 54.55 5,161 28.70 0.0064
2021-05-13 2021-03-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 34,282 249 0.73 4,010 6.00 0.0050
2021-02-10 2020-12-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 34,033 12,251 56.24 3,783 46.29 0.0041
2020-11-13 2020-09-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 21,782 -50,600 -69.91 2,586 -68.45 0.0026
2020-08-13 2020-06-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 72,382 45,900 173.33 8,197 363.63 0.0071
2020-05-14 2020-03-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 26,482 26,482 -63.41 1,768 -78.43 0.0017
2018-05-14 2018-03-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 0 -87,587 -100.00 0 -100.00
2018-02-13 2017-12-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 87,587 -39,700 -31.19 8,040 40.44 0.0089
2017-11-13 2017-09-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 127,287 51,900 68.84 5,725 366.97 0.0067
2017-08-11 2017-06-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 75,387 17,512 30.26 1,226 37.60 0.0016
2017-05-12 2017-03-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 57,875 400 0.70 891 4.09 0.0012
2017-02-13 2016-12-31 13F MADRIGAL PHARMACEUTICALS COM 558868105 57,475 4,488 8.47 856 27.38 0.0014
2016-11-14 2016-09-30 13F MADRIGAL PHARMACEUTICALS COM 558868105 52,987 52,987 672 0.0012
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.