Xenon Pharmaceuticals Inc.
DE ˙ DB ˙ CA98420N1050
45,60 € ↑1,00 (2,24%)
2026-06-04
DEL PRIS
SecurityDE:XP0 / Xenon Pharmaceuticals Inc.
InstitutionVanguard Group Inc
Latest Disclosed Ownership664,641 shares
Latest Disclosed Value $ 29,789,210
Vanguard Group Inc reports 21.93% decrease in ownership of XP0 / Xenon Pharmaceuticals Inc.

On January 29, 2026 - Vanguard Group Inc filed a 13F-HR form disclosing ownership of 664,641 shares of Xenon Pharmaceuticals Inc. (DE:XP0) valued at $24,857,573 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 7, 2025 disclosing 851,386 shares of Xenon Pharmaceuticals Inc.. This represents a change in shares of -21.93% during the quarter. The current value of the position is $30,307,630 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-01-29 2025-12-31 13F XENON PHARMACEUTICALS COM 98420N105 664,641 -186,745 -21.93 29,789 -12.85 0.0004
2025-11-07 2025-09-30 13F XENON PHARMACEUTICALS COM 98420N105 851,386 -21,842 -2.50 34,183 25.07 0.0005
2025-08-11 2025-06-30 13F XENON PHARMACEUTICALS COM 98420N105 873,228 536,714 159.49 27,332 142.09 0.0004
2025-05-09 2025-03-31 13F XENON PHARMACEUTICALS COM 98420N105 336,514 -6,265 -1.83 11,290 -15.97 0.0002
2025-02-11 2024-12-31 13F XENON PHARMACEUTICALS COM 98420N105 342,779 -1,586 -0.46 13,437 -0.89 0.0002
2024-11-13 2024-09-30 13F XENON PHARMACEUTICALS COM 98420N105 344,365 3,213 0.94 13,558 1.92 0.0002
2024-08-13 2024-06-30 13F XENON PHARMACEUTICALS COM 98420N105 341,152 5,517 1.64 13,302 -7.95 0.0003
2024-05-10 2024-03-31 13F XENON PHARMACEUTICALS COM 98420N105 335,635 12,140 3.75 14,449 -3.03 0.0003
2024-03-11 2023-12-31 13F/A-1 XENON PHARMACEUTICALS COM 98420N105 323,495 56,669 21.24 14,900 63.48 0.0003
2024-02-14 2023-12-31 13F XENON PHARMACEUTICALS COM 98420N105 323,495 56,669 14,900 0.0003
2023-12-18 2023-09-30 13F/A-1 XENON PHARMACEUTICALS COM 98420N105 266,826 5,473 2.09 9,115 -9.42 0.0002
2023-11-14 2023-09-30 13F XENON PHARMACEUTICALS COM 98420N105 266,826 5,473 9,115 0.0000
2023-08-14 2023-06-30 13F XENON PHARMACEUTICALS COM 98420N105 261,353 11,999 4.81 10,062 12.75 0.0002
2023-07-14 2023-03-31 13F/A-1 XENON PHARMACEUTICALS COM 98420N105 249,354 57,278 29.82 8,924 17.84 0.0002
2023-05-15 2023-03-31 13F XENON PHARMACEUTICALS COM 98420N105 249,354 57,278 8,924 0.0000
2023-02-10 2022-12-31 13F XENON PHARMACEUTICALS COM 98420N105 192,076 6,884 3.72 7,574 13.27 0.0002
2022-11-14 2022-09-30 13F XENON PHARMACEUTICALS COM 98420N105 185,192 1,347 0.73 6,686 19.56 0.0002
2022-08-12 2022-06-30 13F XENON PHARMACEUTICALS COM 98420N105 183,845 20,377 12.47 5,592 11.91 0.0002
2022-05-13 2022-03-31 13F XENON PHARMACEUTICALS COM 98420N105 163,468 10,102 6.59 4,997 4.28 0.0001
2022-02-14 2021-12-31 13F XENON PHARMACEUTICALS COM 98420N105 153,366 46,174 43.08 4,792 192.55 0.0001
2021-11-12 2021-09-30 13F XENON PHARMACEUTICALS COM 98420N105 107,192 3,756 3.63 1,638 -14.95 0.0000
2021-08-13 2021-06-30 13F XENON PHARMACEUTICALS COM 98420N105 103,436 -3,359 -3.15 1,926 0.73 0.0000
2021-05-14 2021-03-31 13F XENON PHARMACEUTICALS COM 98420N105 106,795 9,232 9.46 1,912 27.47 0.0001
2021-02-12 2020-12-31 13F XENON PHARMACEUTICALS COM 98420N105 97,563 2,670 2.81 1,500 42.72 0.0000
2020-11-16 2020-09-30 13F XENON PHARMACEUTICALS COM 98420N105 94,893 150 0.16 1,051 -11.61 0.0000
2020-08-14 2020-06-30 13F XENON PHARMACEUTICALS COM 98420N105 94,743 94,743 1,189 0.0000
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.