Xenon Pharmaceuticals Inc.
DE ˙ DB ˙ CA98420N1050
45,60 € ↑1,00 (2,24%)
2026-06-04
DEL PRIS
SecurityDE:XP0 / Xenon Pharmaceuticals Inc.
InstitutionRenaissance Technologies Llc
ManagerJames Simons
Latest Disclosed Ownership300,500 shares
Latest Disclosed Value $ 17,474,075
Renaissance Technologies Llc ownership in XP0 / Xenon Pharmaceuticals Inc.

On May 14, 2026 - Renaissance Technologies Llc filed a 13F-HR form disclosing ownership of 300,500 shares of Xenon Pharmaceuticals Inc. (DE:XP0) valued at $14,424,000 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 0 shares of Xenon Pharmaceuticals Inc.. The current value of the position is $13,702,800 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F XENON PHARMACEUTICALS COM 98420N105 300,500 300,500 17,474 0.0273
2026-02-12 2025-12-31 13F XENON PHARMACEUTICALS COM 98420N105 0 -5,200 -100.00 0 -100.00
2025-11-13 2025-09-30 13F XENON PHARMACEUTICALS COM 98420N105 5,200 -3,400 -39.53 209 -22.68 0.0003
2025-08-13 2025-06-30 13F XENON PHARMACEUTICALS COM 98420N105 8,600 -146,100 -94.44 269 -94.82 0.0004
2025-05-14 2025-03-31 13F XENON PHARMACEUTICALS COM 98420N105 154,700 141,000 1,029.20 5,190 866.48 0.0079
2025-02-13 2024-12-31 13F XENON PHARMACEUTICALS COM 98420N105 13,700 -30,300 -68.86 537 -69.00 0.0008
2024-11-13 2024-09-30 13F XENON PHARMACEUTICALS COM 98420N105 44,000 -48,900 -52.64 1,732 -52.18 0.0026
2024-08-09 2024-06-30 13F XENON PHARMACEUTICALS COM 98420N105 92,900 36,500 64.72 3,622 181,000.00 0.0061
2024-05-13 2024-03-31 13F XENON PHARMACEUTICALS COM 98420N105 56,400 23,800 73.01 2 100.00 0.0038
2024-02-13 2023-12-31 13F XENON PHARMACEUTICALS COM 98420N105 32,600 10,700 48.86 2 0.0023
2023-11-14 2023-09-30 13F XENON PHARMACEUTICALS COM 98420N105 21,900 21,900 1 0.0013
2022-08-12 2022-06-30 13F XENON PHARMACEUTICALS COM 98420N105 0 -150,777 -100.00 0 -100.00
2022-05-13 2022-03-31 13F XENON PHARMACEUTICALS COM 98420N105 150,777 -230,100 -60.41 4,609 -61.27 0.0054
2022-02-11 2021-12-31 13F XENON PHARMACEUTICALS COM 98420N105 380,877 -238,200 -38.48 11,899 25.80 0.0148
2021-11-12 2021-09-30 13F XENON PHARMACEUTICALS COM 98420N105 619,077 -38,900 -5.91 9,459 -22.80 0.0122
2021-08-13 2021-06-30 13F XENON PHARMACEUTICALS COM 98420N105 657,977 -35,000 -5.05 12,252 -1.23 0.0153
2021-05-13 2021-03-31 13F XENON PHARMACEUTICALS COM 98420N105 692,977 -77,000 -10.00 12,404 4.75 0.0154
2021-02-10 2020-12-31 13F XENON PHARMACEUTICALS COM 98420N105 769,977 -133,300 -14.76 11,842 18.43 0.0129
2020-11-13 2020-09-30 13F XENON PHARMACEUTICALS COM 98420N105 903,277 -132,000 -12.75 9,999 -22.98 0.0100
2020-08-13 2020-06-30 13F XENON PHARMACEUTICALS COM 98420N105 1,035,277 247,200 31.37 12,982 45.26 0.0112
2020-05-14 2020-03-31 13F XENON PHARMACEUTICALS COM 98420N105 788,077 192,400 32.30 8,937 14.44 0.0087
2020-02-13 2019-12-31 13F XENON PHARMACEUTICALS COM 98420N105 595,677 107,077 21.92 7,809 77.40 0.0060
2019-11-13 2019-09-30 13F XENON PHARMACEUTICALS COM 98420N105 488,600 13,100 2.75 4,402 -6.10 0.0037
2019-08-12 2019-06-30 13F XENON PHARMACEUTICALS COM 98420N105 475,500 3,200 0.68 4,688 -2.31 0.0041
2019-05-14 2019-03-31 13F XENON PHARMACEUTICALS COM 98420N105 472,300 -93,400 -16.51 4,799 34.43 0.0044
2019-02-12 2018-12-31 13F XENON PHARMACEUTICALS COM 98420N105 565,700 38,363 7.27 3,570 -48.71 0.0039
2018-11-13 2018-09-30 13F XENON PHARMACEUTICALS COM 98420N105 527,337 37,837 7.73 6,961 54.59 0.0072
2018-08-13 2018-06-30 13F/A-1 XENON PHARMACEUTICALS COM 98420N105 489,500 201,500 69.97 4,503 219.14 0.0049
2018-08-13 2018-06-30 13F XENON PHARMACEUTICALS COM 98420N105 288,000 1,411
2018-05-14 2018-03-31 13F XENON PHARMACEUTICALS COM 98420N105 288,000 39,000 15.66 1,411 100.71 0.0015
2018-02-13 2017-12-31 13F XENON PHARMACEUTICALS COM 98420N105 249,000 92,600 59.21 703 52.49 0.0008
2017-11-13 2017-09-30 13F XENON PHARMACEUTICALS COM 98420N105 156,400 26,100 20.03 461 12.44 0.0005
2017-08-11 2017-06-30 13F XENON PHARMACEUTICALS COM 98420N105 130,300 -86,790 -39.98 410 -52.76 0.0005
2017-05-12 2017-03-31 13F XENON PHARMACEUTICALS COM 98420N105 217,090 102,890 90.10 868 -1.25 0.0012
2017-02-13 2016-12-31 13F XENON PHARMACEUTICALS COM 98420N105 114,200 18,000 18.71 879 12.84 0.0014
2016-11-14 2016-09-30 13F XENON PHARMACEUTICALS COM 98420N105 96,200 47,700 98.35 779 172.38 0.0014
2016-08-12 2016-06-30 13F XENON PHARMACEUTICALS COM 98420N105 48,500 14,700 43.49 286 21.19 0.0005
2016-05-13 2016-03-31 13F XENON PHARMACEUTICALS COM 98420N105 33,800 -5,305 -13.57 236 -24.84 0.0004
2016-02-11 2015-12-31 13F XENON PHARMACEUTICALS COM 98420N105 39,105 18,605 90.76 314 85.80 0.0007
2015-11-12 2015-09-30 13F XENON PHARMACEUTICALS COM 98420N105 20,500 -21,500 -51.19 169 -65.08 0.0004
2015-08-14 2015-06-30 13F XENON PHARMACEUTICALS COM 98420N105 42,000 42,000 484 0.0011
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.