OPKO Health, Inc.
DE ˙ DB ˙ US68375N1037
1,18 € ↑0,12 (11,32%)
2026-05-28
DEL PRIS
SecurityDE:XCY / OPKO Health, Inc.
InstitutionState Street Corp
Latest Disclosed Ownership9,501,377 shares
Latest Disclosed Value $ 10,831,570
State Street Corp reports 6.14% increase in ownership of XCY / OPKO Health, Inc.

On May 15, 2026 - State Street Corp filed a 13F-HR form disclosing ownership of 9,501,377 shares of OPKO Health, Inc. (DE:XCY) valued at $8,898,040 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 8,951,762 shares of OPKO Health, Inc.. This represents a change in shares of 6.14% during the quarter. The current value of the position is $11,211,625 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F OPKO HEALTH COM 68375N103 9,501,377 549,615 6.14 10,832 -3.97 0.0004
2026-02-13 2025-12-31 13F OPKO HEALTH COM 68375N103 8,951,762 -46,178 -0.51 11,279 -19.12 0.0004
2025-11-14 2025-09-30 13F OPKO HEALTH COM 68375N103 8,997,940 416,100 4.85 13,947 23.11 0.0005
2025-08-14 2025-06-30 13F OPKO HEALTH COM 68375N103 8,581,840 442,344 5.43 11,328 -16.16 0.0004
2025-05-15 2025-03-31 13F OPKO HEALTH COM 68375N103 8,139,496 -935,402 -10.31 13,512 1.28 0.0006
2025-02-14 2024-12-31 13F OPKO HEALTH COM 68375N103 9,074,898 359,388 4.12 13,340 2.73 0.0005
2024-11-14 2024-09-30 13F OPKO HEALTH COM 68375N103 8,715,510 -832,705 -8.72 12,986 8.81 0.0005
2024-08-14 2024-06-30 13F OPKO HEALTH COM 68375N103 9,548,215 -654,313 -6.41 11,935 -2.52 0.0005
2024-05-15 2024-03-31 13F OPKO HEALTH COM 68375N103 10,202,528 895,844 9.63 12,243 -12.88 0.0005
2024-02-14 2023-12-31 13F OPKO HEALTH COM 68375N103 9,306,684 -31,744 -0.34 14,053 -5.94 0.0007
2023-11-14 2023-09-30 13F OPKO HEALTH COM 68375N103 9,338,428 193,432 2.12 14,941 -24.71 0.0008
2023-08-14 2023-06-30 13F OPKO HEALTH COM 68375N103 9,144,996 -1,357,379 -12.92 19,845 29.42 0.0010
2023-05-15 2023-03-31 13F OPKO HEALTH COM 68375N103 10,502,375 57,057 0.55 15,333 17.44 0.0009
2023-05-15 2022-12-31 13F/A-99 OPKO HEALTH COM 68375N103 10,445,318 71,045 0.68 13,057 -33.41 0.0008
2023-05-15 2022-12-31 13F OPKO HEALTH COM 68375N103 10,445,318 71,045 13,057 0.0008
2022-11-15 2022-09-30 13F OPKO HEALTH COM 68375N103 10,374,273 507,764 5.15 19,607 -21.45 0.0012
2022-08-15 2022-06-30 13F OPKO HEALTH COM 68375N103 9,866,509 -17,822,322 -64.37 24,962 -73.79 0.0015
2022-05-16 2022-03-31 13F OPKO HEALTH COM 68375N103 27,688,831 10,014,088 56.66 95,250 12.04 0.0047
2022-02-14 2021-12-31 13F OPKO HEALTH COM 68375N103 17,674,743 -5,699,872 -24.38 85,016 -0.35 0.0040
2021-11-15 2021-09-30 13F OPKO HEALTH COM 68375N103 23,374,615 2,577,407 12.39 85,317 1.29 0.0045
2021-08-16 2021-06-30 13F OPKO HEALTH COM 68375N103 20,797,208 1,488,452 7.71 84,229 1.68 0.0044
2021-07-09 2021-03-31 13F/A-1 OPKO HEALTH COM 68375N103 19,308,756 -3,558,594 -15.56 82,835 -8.29 0.0047
2021-05-17 2021-03-31 13F OPKO HEALTH COM 68375N103 19,308,756 -3,558,594 82,835 0.0048
2021-02-16 2020-12-31 13F OPKO HEALTH COM 68375N103 22,867,350 -2,232,463 -8.89 90,326 -2.47 0.0055
2020-11-10 2020-09-30 13F OPKO HEALTH COM 68375N103 25,099,813 -5,358,538 -17.59 92,618 -10.83 0.0063
2020-08-14 2020-06-30 13F OPKO HEALTH COM 68375N103 30,458,351 12,017,920 65.17 103,863 320.33 0.0076
2020-06-19 2020-03-31 13F/A-1 OPKO HEALTH COM 68375N103 18,440,431 542,095 3.03 24,710 -6.08 0.0022
2020-05-11 2020-03-31 13F OPKO HEALTH COM 68375N103 18,440,431 542,095 24,710 2,170.0355
2020-02-06 2019-12-31 13F OPKO HEALTH COM 68375N103 17,898,336 3,853,461 27.44 26,311 -10.37 0.0018
2019-11-14 2019-09-30 13F OPKO HEALTH COM 68375N103 14,044,875 -4,363,277 -23.70 29,354 -34.65 0.0022
2019-08-14 2019-06-30 13F OPKO HEALTH COM 68375N103 18,408,152 -1,719,442 -8.54 44,916 -14.50 0.0033
2019-05-15 2019-03-31 13F OPKO HEALTH COM 68375N103 20,127,594 4,485,484 28.68 52,533 11.58 0.0041
2019-02-12 2018-12-31 13F OPKO HEALTH COM 68375N103 15,642,110 -6,684,649 -29.94 47,083 -39.05 0.0043
2018-11-09 2018-09-30 13F OPKO HEALTH Common equity shares 68375N103 22,326,759 7,265,701 48.24 77,252 9.14 0.0059
2018-08-14 2018-06-30 13F OPKO HEALTH Common equity shares 68375N103 15,061,058 -2,874,493 -16.03 70,784 24.50 0.0059
2018-05-15 2018-03-31 13F OPKO HEALTH Common equity shares 68375N103 17,935,551 3,851,745 27.35 56,854 -17.62 0.0048
2018-02-14 2017-12-31 13F OPKO HEALTH Common equity shares 68375N103 14,083,806 1,462,485 11.59 69,012 -20.30 0.0055
2017-11-14 2017-09-30 13F OPKO HEALTH Common equity shares 68375N103 12,621,321 1,272,558 11.21 86,587 15.96 0.0075
2017-08-14 2017-06-30 13F OPKO HEALTH Common equity shares 68375N103 11,348,763 422,203 3.86 74,671 -14.58 0.0066
2017-05-15 2017-03-31 13F OPKO HEALTH Common equity shares 68375N103 10,926,560 3,138,685 40.30 87,412 20.69 0.0078
2017-02-09 2016-12-31 13F OPKO HEALTH Common equity shares 68375N103 7,787,875 226,132 2.99 72,427 -9.56 0.0068
2017-01-13 2016-09-30 13F/A-1 OPKO HEALTH Common equity shares 68375N103 7,561,743 107,019 1.44 80,079 15.01 0.0081
2016-11-14 2016-09-30 13F OPKO HEALTH Common equity shares 68375N103 7,561,743 80,079
2016-08-12 2016-06-30 13F OPKO HEALTH Common equity shares 68375N103 7,454,724 773,867 11.58 69,627 0.30 0.0075
2016-05-20 2016-03-31 13F/A-1 OPKO HEALTH Common equity shares 68375N103 6,680,857 -36,937 -0.55 69,417 2.82 0.0075
2016-05-12 2016-03-31 13F OPKO HEALTH Common equity shares 68375N103 6,680,857 69,417
2016-02-16 2015-12-31 13F OPKO HEALTH Common equity shares 68375N103 6,717,794 585,753 9.55 67,510 30.91 0.0074
2015-11-16 2015-09-30 13F OPKO HEALTH Common equity shares 68375N103 6,132,041 2,168,136 54.70 51,570 -19.09 0.0060
2015-08-13 2015-06-30 13F OPKO HEALTH Common equity shares 68375N103 3,963,905 -853,721 -17.72 63,738 -6.63 0.0068
2015-05-15 2015-03-31 13F OPKO HEALTH Common equity shares 68375N103 4,817,626 -518,410 -9.72 68,267 28.06 0.0070
2015-02-11 2014-12-31 13F OPKO HEALTH Common equity shares 68375N103 5,336,036 255,832 5.04 53,308 23.32 0.0053
2014-11-12 2014-09-30 13F/A-1 OPKO HEALTH Common equity shares 68375N103 5,080,204 228,377 4.71 43,228 0.80 0.0047
2014-11-10 2014-09-30 13F OPKO HEALTH Common equity shares 68375N103 5,080,204 43,228
2014-08-12 2014-06-30 13F OPKO HEALTH Common equity shares 68375N103 4,851,827 -276,351 -5.39 42,886 -10.27 0.0046
2014-05-15 2014-03-31 13F/A-1 OPKO HEALTH Common equity shares 68375N103 5,128,178 346,713 7.25 47,797 18.43 0.0054
2014-05-13 2014-03-31 13F OPKO HEALTH Common equity shares 68375N103 5,129,678 47,811
2014-02-06 2013-12-31 13F/A-1 OPKO HEALTH Common equity shares 68375N103 4,781,465 -758,662 -13.69 40,359 -17.31 0.0045
2014-02-06 2013-12-31 13F OPKO HEALTH Common equity shares 68375N103 3,256,154 15,659
2013-11-12 2013-09-30 13F OPKO HEALTH Common Stock 68375N103 5,540,127 753,572 15.74 48,810 43.63 0.0060
2013-08-08 2013-06-30 13F OPKO HEALTH Common Stock 68375N103 4,786,555 4,786,555 33,983 0.0044
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.