Vanda Pharmaceuticals Inc.
DE ˙ DB ˙ US9216591084
5,26 € ↑0,09 (1,74%)
2026-06-05
DEL PRIS
SecurityDE:VM4 / Vanda Pharmaceuticals Inc.
InstitutionTwo Sigma Advisers, Lp
Latest Disclosed Ownership1,049,300 shares
Latest Disclosed Value $ 9,254,826
Two Sigma Advisers, Lp reports 15.40% increase in ownership of VM4 / Vanda Pharmaceuticals Inc.

On February 17, 2026 - Two Sigma Advisers, Lp filed a 13F-HR form disclosing ownership of 1,049,300 shares of Vanda Pharmaceuticals Inc. (DE:VM4) valued at $6,558,125 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 14, 2025 disclosing 909,300 shares of Vanda Pharmaceuticals Inc.. This represents a change in shares of 15.40% during the quarter. The current value of the position is $5,519,318 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-17 2025-12-31 13F VANDA PHARMACEUTICALS COM 921659108 1,049,300 140,000 15.40 9,255 103.97 0.0180
2025-11-14 2025-09-30 13F VANDA PHARMACEUTICALS COM 921659108 909,300 100,100 12.37 4,537 18.80 0.0091
2025-08-14 2025-06-30 13F VANDA PHARMACEUTICALS COM 921659108 809,200 574,000 244.05 3,819 253.94 0.0078
2025-05-15 2025-03-31 13F VANDA PHARMACEUTICALS COM 921659108 235,200 78,900 50.48 1,080 44.25 0.0024
2025-02-14 2024-12-31 13F VANDA PHARMACEUTICALS COM 921659108 156,300 15,700 11.17 749 13.51 0.0017
2024-11-14 2024-09-30 13F VANDA PHARMACEUTICALS COM 921659108 140,600 -73,500 -34.33 659 -45.49 0.0015
2024-08-14 2024-06-30 13F VANDA PHARMACEUTICALS COM 921659108 214,100 -489,800 -69.58 1,210 -58.21 0.0027
2024-05-15 2024-03-31 13F VANDA PHARMACEUTICALS COM 921659108 703,900 -182,600 -20.60 2,893 -22.67 0.0067
2024-02-14 2023-12-31 13F VANDA PHARMACEUTICALS COM 921659108 886,500 118,200 15.38 3,741 12.71 0.0088
2023-11-14 2023-09-30 13F VANDA PHARMACEUTICALS COM 921659108 768,300 142,600 22.79 3,319 -19.50 0.0085
2023-08-14 2023-06-30 13F VANDA PHARMACEUTICALS COM 921659108 625,700 48,300 8.37 4,123 5.18 0.0105
2023-05-15 2023-03-31 13F VANDA PHARMACEUTICALS COM 921659108 577,400 124,000 27.35 3,921 17.01 0.0101
2023-02-14 2022-12-31 13F VANDA PHARMACEUTICALS COM 921659108 453,400 15,600 3.56 3,351 -22.54 0.0094
2022-11-14 2022-09-30 13F VANDA PHARMACEUTICALS COM 921659108 437,800 -147,900 -25.25 4,325 -32.25 0.0125
2022-08-15 2022-06-30 13F VANDA PHARMACEUTICALS COM 921659108 585,700 -300 -0.05 6,384 -3.68 0.0181
2022-05-16 2022-03-31 13F VANDA PHARMACEUTICALS COM 921659108 586,000 38,600 7.05 6,628 -22.83 0.0176
2022-02-14 2021-12-31 13F VANDA PHARMACEUTICALS COM 921659108 547,400 159,100 40.97 8,589 29.06 0.0215
2021-11-15 2021-09-30 13F VANDA PHARMACEUTICALS COM 921659108 388,300 -20,800 -5.08 6,655 -24.37 0.0173
2021-08-16 2021-06-30 13F VANDA PHARMACEUTICALS COM 921659108 409,100 83,800 25.76 8,800 80.11 0.0232
2021-05-17 2021-03-31 13F VANDA PHARMACEUTICALS COM 921659108 325,300 55,700 20.66 4,886 37.91 0.0134
2021-02-16 2020-12-31 13F VANDA PHARMACEUTICALS COM 921659108 269,600 -42,200 -13.53 3,543 17.63 0.0095
2020-11-16 2020-09-30 13F VANDA PHARMACEUTICALS COM 921659108 311,800 -129,800 -29.39 3,012 -40.38 0.0086
2020-09-15 2020-06-30 13F/A-1 VANDA PHARMACEUTICALS COM 921659108 441,600 24,400 5.85 5,052 16.89 0.0148
2020-08-14 2020-06-30 13F VANDA PHARMACEUTICALS COM 921659108 441,600 24,400 5,052 14,598.6022
2020-05-15 2020-03-31 13F VANDA PHARMACEUTICALS COM 921659108 417,200 35,100 9.19 4,322 -31.07 0.0165
2020-02-14 2019-12-31 13F VANDA PHARMACEUTICALS COM 921659108 382,100 4,200 1.11 6,270 24.93 0.0145
2019-11-14 2019-09-30 13F VANDA PHARMACEUTICALS COM 921659108 377,900 -42,200 -10.05 5,019 -15.21 0.0123
2019-08-14 2019-06-30 13F VANDA PHARMACEUTICALS COM 921659108 420,100 118,600 39.34 5,919 6.69 0.0147
2019-05-15 2019-03-31 13F VANDA PHARMACEUTICALS COM 921659108 301,500 72,800 31.83 5,548 -7.16 0.0140
2019-02-14 2018-12-31 13F VANDA PHARMACEUTICALS COM 921659108 228,700 -43,300 -15.92 5,976 -4.26 0.0163
2018-11-14 2018-09-30 13F VANDA PHARMACEUTICALS COM 921659108 272,000 -28,100 -9.36 6,242 9.18 0.0152
2018-08-14 2018-06-30 13F VANDA PHARMACEUTICALS COM 921659108 300,100 162,600 118.25 5,717 146.74 0.0154
2018-05-15 2018-03-31 13F VANDA PHARMACEUTICALS COM 921659108 137,500 30,300 28.26 2,317 42.23 0.0063
2018-02-14 2017-12-31 13F VANDA PHARMACEUTICALS COM 921659108 107,200 -44,100 -29.15 1,629 -39.84 0.0044
2017-11-14 2017-09-30 13F VANDA PHARMACEUTICALS COM 921659108 151,300 4,200 2.86 2,708 12.93 0.0077
2017-08-14 2017-06-30 13F VANDA PHARMACEUTICALS COM 921659108 147,100 32,800 28.70 2,398 49.88 0.0079
2017-05-15 2017-03-31 13F VANDA PHARMACEUTICALS COM 921659108 114,300 -46,500 -28.92 1,600 -37.62 0.0052
2017-02-14 2016-12-31 13F VANDA PHARMACEUTICALS COM 921659108 160,800 31,900 24.75 2,565 19.58 0.0098
2016-11-14 2016-09-30 13F VANDA PHARMACEUTICALS COM 921659108 128,900 73,800 133.94 2,145 247.65 0.0091
2016-08-15 2016-06-30 13F VANDA PHARMACEUTICALS COM 921659108 55,100 55,100 617 0.0031
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.