Innoviva, Inc.
DE ˙ DB ˙ US45781M1018
19,20 € ↑0,70 (3,78%)
2026-06-04
DEL PRIS
SecurityDE:HVE / Innoviva, Inc.
InstitutionTwo Sigma Advisers, Lp
Latest Disclosed Ownership157,030 shares
Latest Disclosed Value $ 3,139,030
Two Sigma Advisers, Lp reports 69.21% increase in ownership of HVE / Innoviva, Inc.

On February 17, 2026 - Two Sigma Advisers, Lp filed a 13F-HR form disclosing ownership of 157,030 shares of Innoviva, Inc. (DE:HVE) valued at $2,606,698 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 14, 2025 disclosing 92,800 shares of Innoviva, Inc.. This represents a change in shares of 69.21% during the quarter. The current value of the position is $3,014,976 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-17 2025-12-31 13F INNOVIVA COM 45781M101 157,030 64,230 69.21 3,139 85.41 0.0061
2025-11-14 2025-09-30 13F INNOVIVA COM 45781M101 92,800 -225,000 -70.80 1,694 -73.48 0.0034
2025-08-14 2025-06-30 13F INNOVIVA COM 45781M101 317,800 -253,700 -44.39 6,385 -38.38 0.0131
2025-05-15 2025-03-31 13F INNOVIVA COM 45781M101 571,500 367,000 179.46 10,361 192.02 0.0233
2025-02-14 2024-12-31 13F INNOVIVA COM 45781M101 204,500 -173,800 -45.94 3,548 -51.42 0.0082
2024-11-14 2024-09-30 13F INNOVIVA COM 45781M101 378,300 21,100 5.91 7,305 24.68 0.0171
2024-08-14 2024-06-30 13F INNOVIVA COM 45781M101 357,200 -48,900 -12.04 5,858 -5.33 0.0131
2024-05-15 2024-03-31 13F INNOVIVA COM 45781M101 406,100 388,200 2,168.72 6,189 8,494.44 0.0143
2024-02-14 2023-12-31 13F THESEUS PHARMACEUTICALS COM 88369M101 17,900 5,700 46.72 72 125.00 0.0002
2024-02-14 2023-12-31 13F INNOVIVA COM 45781M101 211,000 -15,700 3,384 0.0079
2023-11-14 2023-09-30 13F THESEUS PHARMACEUTICALS COM 88369M101 12,200 -18,000 -59.60 33 -88.61 0.0001
2023-11-14 2023-09-30 13F INNOVIVA COM 45781M101 226,700 41,200 2,945 0.0075
2023-08-14 2023-06-30 13F THESEUS PHARMACEUTICALS COM 88369M101 30,200 1,800 6.34 282 11.51 0.0007
2023-08-14 2023-06-30 13F INNOVIVA COM 45781M101 185,500 67,000 2,361 0.0060
2023-05-15 2023-03-31 13F THESEUS PHARMACEUTICALS COM 88369M101 28,400 -236,200 -89.27 252 -92.81 0.0007
2023-05-15 2023-03-31 13F INNOVIVA COM 45781M101 118,500 -146,100 1,333 0.0034
2023-02-14 2022-12-31 13F INNOVIVA COM 45781M101 264,600 126,500 91.60 3,506 118.65 0.0098
2022-11-14 2022-09-30 13F INNOVIVA COM 45781M101 138,100 -338,100 -71.00 1,603 -77.19 0.0046
2022-08-15 2022-06-30 13F INNOVIVA COM 45781M101 476,200 -86,300 -15.34 7,029 -35.42 0.0199
2022-05-16 2022-03-31 13F INNOVIVA COM 45781M101 562,500 357,900 174.93 10,884 208.42 0.0289
2022-02-14 2021-12-31 13F INNOVIVA COM 45781M101 204,600 110,400 117.20 3,529 124.21 0.0088
2021-11-15 2021-09-30 13F INNOVIVA COM 45781M101 94,200 94,200 1,574 0.0041
2020-11-16 2020-09-30 13F INNOVIVA COM 45781M101 0 -48,634 -100.00 0 -100.00
2020-09-15 2020-06-30 13F/A-1 INNOVIVA COM 45781M101 48,634 20,800 74.73 680 107.95 0.0020
2020-08-14 2020-06-30 13F INNOVIVA COM 45781M101 48,634 20,800 680 1,964.9742
2020-05-15 2020-03-31 13F INNOVIVA COM 45781M101 27,834 -36,800 -56.94 327 -64.26 0.0013
2020-02-14 2019-12-31 13F INNOVIVA COM 45781M101 64,634 -41,766 -39.25 915 -18.38 0.0021
2019-11-14 2019-09-30 13F INNOVIVA COM 45781M101 106,400 -86,834 -44.94 1,121 -60.15 0.0027
2019-08-14 2019-06-30 13F INNOVIVA COM 45781M101 193,234 -56,500 -22.62 2,813 -19.72 0.0070
2019-05-15 2019-03-31 13F INNOVIVA COM 45781M101 249,734 -24,500 -8.93 3,504 -26.77 0.0088
2019-02-14 2018-12-31 13F INNOVIVA COM 45781M101 274,234 89,600 48.53 4,785 70.04 0.0131
2018-11-14 2018-09-30 13F INNOVIVA COM 45781M101 184,634 -42,266 -18.63 2,814 -10.12 0.0069
2018-08-14 2018-06-30 13F INNOVIVA COM 45781M101 226,900 80,966 55.48 3,131 28.69 0.0084
2018-05-15 2018-03-31 13F INNOVIVA COM 45781M101 145,934 73,800 102.31 2,433 137.60 0.0066
2018-02-14 2017-12-31 13F INNOVIVA COM 45781M101 72,134 40,100 125.18 1,024 126.55 0.0028
2017-11-14 2017-09-30 13F INNOVIVA COM 45781M101 32,034 -15,500 -32.61 452 -25.66 0.0013
2017-08-14 2017-06-30 13F INNOVIVA COM 45781M101 47,534 -9,000 -15.92 608 -22.25 0.0020
2017-05-15 2017-03-31 13F INNOVIVA COM 45781M101 56,534 -67,700 -54.49 782 -41.16 0.0026
2017-02-14 2016-12-31 13F INNOVIVA COM 45781M101 124,234 -25,400 -16.97 1,329 -19.16 0.0051
2016-11-14 2016-09-30 13F INNOVIVA COM 45781M101 149,634 -30,500 -16.93 1,644 -13.34 0.0070
2016-08-15 2016-06-30 13F INNOVIVA COM 45781M101 180,134 150,100 499.77 1,897 401.85 0.0096
2016-05-16 2016-03-31 13F INNOVIVA COM 45781M101 30,034 30,034 378 0.0021
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.