Alnylam Pharmaceuticals, Inc.
260,50 €
↑8,70
(3,46%)
2026-06-04
DEL PRIS
DEL PRIS
| Security | DE:DUL / Alnylam Pharmaceuticals, Inc. |
| Institution | Two Sigma Advisers, Lp |
| Latest Disclosed Ownership | 1,132,560 shares |
| Latest Disclosed Value | $ 450,362,484 |
Two Sigma Advisers, Lp reports 26.90% increase in ownership of DUL / Alnylam Pharmaceuticals, Inc.
On February 17, 2026 - Two Sigma Advisers, Lp filed a 13F-HR form disclosing ownership of 1,132,560 shares of Alnylam Pharmaceuticals, Inc. (DE:DUL) valued at $382,692,024 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 14, 2025 disclosing 892,500 shares of Alnylam Pharmaceuticals, Inc.. This represents a change in shares of 26.90% during the quarter. The current value of the position is $295,031,880 USD.
Institutional Ownership: 13F and NPORT Filings
The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.
Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.
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Disclosed Equity Positions (from 13F/NPORT Filings)
| File Date |
Effective Date | Form | Security | Class | ID | Avg Price Paid (Est) |
Reported Shares |
ΔShares | ΔShares (%) |
Reported Value (x1000) |
ΔValue (%) |
Alloc (%) |
ΔAlloc | ΔAlloc (%) | Cost Basis (x1000) |
Unrealized Gain/Loss (x1000) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026-02-17 | 2025-12-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 1,132,560 | 240,060 | 26.90 | 450,362 | 10.66 | 0.8756 | |||||
| 2025-11-14 | 2025-09-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 892,500 | 626,400 | 235.40 | 406,980 | 369.02 | 0.8144 | |||||
| 2025-08-14 | 2025-06-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 266,100 | -9,700 | -3.52 | 86,773 | 16.52 | 0.1778 | |||||
| 2025-05-15 | 2025-03-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 275,800 | 197,000 | 250.00 | 74,472 | 301.63 | 0.1677 | |||||
| 2025-02-14 | 2024-12-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 78,800 | -24,300 | -23.57 | 18,542 | -34.61 | 0.0429 | |||||
| 2024-11-14 | 2024-09-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 103,100 | -155,600 | -60.15 | 28,356 | -54.89 | 0.0664 | |||||
| 2024-08-14 | 2024-06-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 258,700 | 69,100 | 36.45 | 62,864 | 121.86 | 0.1402 | |||||
| 2024-05-15 | 2024-03-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 189,600 | 189,600 | 28,336 | 0.0656 | |||||||
| 2024-02-14 | 2023-12-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 0 | -35,900 | -100.00 | 0 | -100.00 | ||||||
| 2023-11-14 | 2023-09-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 35,900 | -157,700 | -81.46 | 6,358 | -82.71 | 0.0163 | |||||
| 2023-08-14 | 2023-06-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 193,600 | 38,500 | 24.82 | 36,772 | 18.36 | 0.0937 | |||||
| 2023-05-15 | 2023-03-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 155,100 | 35,100 | 29.25 | 31,070 | 8.95 | 0.0801 | |||||
| 2023-02-14 | 2022-12-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 120,000 | 56,200 | 88.09 | 28,518 | 123.32 | 0.0796 | |||||
| 2022-11-14 | 2022-09-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 63,800 | 51,400 | 414.52 | 12,770 | 605.91 | 0.0370 | |||||
| 2022-08-15 | 2022-06-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 12,400 | -34,300 | -73.45 | 1,809 | -76.28 | 0.0051 | |||||
| 2022-05-16 | 2022-03-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 46,700 | 42,900 | 1,128.95 | 7,626 | 1,084.16 | 0.0203 | |||||
| 2022-02-14 | 2021-12-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 3,800 | 3,800 | 644 | 0.0016 | |||||||
| 2021-08-16 | 2021-06-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 0 | -31,900 | -100.00 | 0 | -100.00 | ||||||
| 2021-05-17 | 2021-03-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 31,900 | 28,200 | 762.16 | 4,504 | 836.38 | 0.0124 | |||||
| 2021-02-16 | 2020-12-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 3,700 | 3,700 | 481 | 0.0013 | |||||||
| 2020-11-16 | 2020-09-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 0 | -8,300 | -100.00 | 0 | -100.00 | ||||||
| 2020-09-15 | 2020-06-30 | 13F/A-1 | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 8,300 | 8,300 | 1,229 | 0.0036 | |||||||
| 2020-08-14 | 2020-06-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 8,300 | 8,300 | 1,229 | 3,551.4018 | |||||||
| 2019-08-14 | 2019-06-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 0 | -70,800 | -100.00 | 0 | -100.00 | ||||||
| 2019-05-15 | 2019-03-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 70,800 | -46,300 | -39.54 | 6,616 | -22.51 | 0.0167 | |||||
| 2019-02-14 | 2018-12-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 117,100 | -72,400 | -38.21 | 8,538 | -48.52 | 0.0233 | |||||
| 2018-11-14 | 2018-09-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 189,500 | -44,322 | -18.96 | 16,585 | -27.98 | 0.0405 | |||||
| 2018-08-14 | 2018-06-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 233,822 | -123,400 | -34.54 | 23,029 | -45.87 | 0.0619 | |||||
| 2018-05-15 | 2018-03-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 357,222 | 248,200 | 227.66 | 42,545 | 207.16 | 0.1154 | |||||
| 2018-02-14 | 2017-12-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 109,022 | 109,022 | 13,851 | 0.0373 | |||||||
| 2016-08-15 | 2016-06-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 0 | -101,622 | -100.00 | 0 | -100.00 | ||||||
| 2016-05-16 | 2016-03-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 101,622 | 97,300 | 2,251.27 | 6,379 | 1,467.32 | 0.0357 | |||||
| 2016-02-16 | 2015-12-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 4,322 | 4,322 | 0.00 | 407 | 0.0024 | ||||||
| 2015-11-16 | 2015-09-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 0 | -5,022 | -100.00 | 0 | -100.00 | ||||||
| 2016-02-09 | 2015-06-30 | 13F/A-1 | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 5,022 | -1,500 | -23.00 | 602 | -11.60 | 0.0046 | |||||
| 2015-08-14 | 2015-06-30 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 5,022 | 602 | |||||||||
| 2016-02-09 | 2015-03-31 | 13F/A-1 | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 6,522 | -900 | -12.13 | 681 | -5.42 | 0.0052 | |||||
| 2015-05-15 | 2015-03-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 6,522 | 681 | |||||||||
| 2016-02-09 | 2014-12-31 | 13F/A-1 | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 7,422 | 7,422 | 720 | 0.0058 | |||||||
| 2015-02-17 | 2014-12-31 | 13F | ALNYLAM PHARMACEUTICALS | COM | 02043Q107 | 7,422 | 720 | 0.0058 |
Legend
- Shares
- The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
- Value
- The total value of the shares as of the effective date. This is provided in the filing.
- Avg. Share Price
- The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
- Class
- This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
- Allocation (%)
- The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
- Change in Allocation
- The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
- Change in Allocation (%)
- The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
- Cost Basis
- The total cost of the shares held. This is calculated as reported shares * avg. share price
- Unrealized Gain/Loss
- This is the market value of the position as of the effective date minus the cost basis.
