Krystal Biotech, Inc.
DE ˙ DB ˙ US5011471027
257,90 € ↓ -1,10 (-0,42%)
2026-06-04
DEL PRIS
SecurityDE:4KB / Krystal Biotech, Inc.
InstitutionState Street Corp
Latest Disclosed Ownership1,278,975 shares
Ownership 4.40%
State Street Corp ownership in 4KB / Krystal Biotech, Inc.

2025-02-05 - State Street Corp has filed an SCHEDULE 13G form with the Securities and Exchange Commission (SEC) disclosing ownership of 1,278,975 shares of Krystal Biotech, Inc. (DE:4KB). This represents 4.4 percent ownership of the company. In their previous filing dated 2024-10-16 , State Street Corp had reported owning 1,452,811 shares, indicating a decrease of -11.97 percent.

Institutional Ownership: 13D/G Filings

This table shows a history of the 13D/G filings made by the investor and/or investor group. Note that the share values in this table are not directly comparable to any numbers shown in the 13F table (if any).

File
Date		Effective
Date		Form Prev
Shares		 Latest
Shares		 ΔShares
(Percent)		 Ownership
(Percent)		 ΔOwnership
(Percent)
2025-02-05 2025-02-05 13G 1,452,811 1,278,975 -11.97 4.40 -13.73
2024-10-16 2024-10-16 13G 1,452,811 5.10

Important Note: One of the primary uses of the 13D/G filings is to evaluate the ability of a firm to control a company (ie, the "beneficial ownership"). To that end, firms are required to report not just direct holdings in companies, but indirect holdings that they control. For investment firms, these indirect holdings can include shares in funds they manage, advisory accounts, and in the case of activist campaigns, pledged votes. Therefore, share counts listed in 13D/G filings can differ significantly than share counts listed in 13F filings.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F KRYSTAL BIOTECH COM 501147102 1,314,434 -27,869 -2.08 339,545 2.60 0.0117
2026-02-13 2025-12-31 13F KRYSTAL BIOTECH COM 501147102 1,342,303 -53,664 -3.84 330,931 34.29 0.0111
2025-11-14 2025-09-30 13F KRYSTAL BIOTECH COM 501147102 1,395,967 40,621 3.00 246,430 32.27 0.0085
2025-08-14 2025-06-30 13F KRYSTAL BIOTECH COM 501147102 1,355,346 128,639 10.49 186,306 -15.77 0.0070
2025-05-15 2025-03-31 13F KRYSTAL BIOTECH COM 501147102 1,226,707 -52,268 -4.09 221,175 10.39 0.0091
2025-02-14 2024-12-31 13F KRYSTAL BIOTECH COM 501147102 1,278,975 -173,836 -11.97 200,364 -24.24 0.0079
2024-11-14 2024-09-30 13F KRYSTAL BIOTECH COM 501147102 1,452,811 119,936 9.00 264,455 8.04 0.0108
2024-08-14 2024-06-30 13F KRYSTAL BIOTECH COM 501147102 1,332,875 388,328 41.11 244,769 45.64 0.0107
2024-05-15 2024-03-31 13F KRYSTAL BIOTECH COM 501147102 944,547 -292,950 -23.67 168,063 9.47 0.0075
2024-02-14 2023-12-31 13F KRYSTAL BIOTECH COM 501147102 1,237,497 205,670 19.93 153,524 28.27 0.0075
2023-11-14 2023-09-30 13F KRYSTAL BIOTECH COM 501147102 1,031,827 128,136 14.18 119,692 12.82 0.0066
2023-08-14 2023-06-30 13F KRYSTAL BIOTECH COM 501147102 903,691 -122,704 -11.95 106,093 29.11 0.0056
2023-05-15 2023-03-31 13F KRYSTAL BIOTECH COM 501147102 1,026,395 -12,588 -1.21 82,173 -0.16 0.0046
2023-05-15 2022-12-31 13F/A-99 KRYSTAL BIOTECH COM 501147102 1,038,983 44,839 4.51 82,308 18.78 0.0048
2023-05-15 2022-12-31 13F KRYSTAL BIOTECH COM 501147102 1,038,983 44,839 82,308 0.0048
2022-11-15 2022-09-30 13F KRYSTAL BIOTECH COM 501147102 994,144 -41,897 -4.04 69,292 1.86 0.0044
2022-08-15 2022-06-30 13F KRYSTAL BIOTECH COM 501147102 1,036,041 -32,615 -3.05 68,026 -4.33 0.0041
2022-05-16 2022-03-31 13F KRYSTAL BIOTECH COM 501147102 1,068,656 366,855 52.27 71,108 44.85 0.0035
2022-02-14 2021-12-31 13F KRYSTAL BIOTECH COM 501147102 701,801 -35,252 -4.78 49,091 27.57 0.0023
2021-11-15 2021-09-30 13F KRYSTAL BIOTECH COM 501147102 737,053 24,056 3.37 38,482 -20.63 0.0020
2021-08-16 2021-06-30 13F KRYSTAL BIOTECH COM 501147102 712,997 54,039 8.20 48,484 -4.50 0.0026
2021-07-09 2021-03-31 13F/A-1 KRYSTAL BIOTECH COM 501147102 658,958 98,708 17.62 50,766 51.02 0.0029
2021-05-17 2021-03-31 13F KRYSTAL BIOTECH COM 501147102 658,958 98,708 50,766 0.0029
2021-02-16 2020-12-31 13F KRYSTAL BIOTECH COM 501147102 560,250 -32,086 -5.42 33,615 31.82 0.0021
2020-11-10 2020-09-30 13F KRYSTAL BIOTECH COM 501147102 592,336 -102,489 -14.75 25,500 -11.40 0.0017
2020-08-14 2020-06-30 13F KRYSTAL BIOTECH COM 501147102 694,825 227,432 48.66 28,780 42.40 0.0021
2020-06-19 2020-03-31 13F/A-1 KRYSTAL BIOTECH COM 501147102 467,393 11,168 2.45 20,210 -20.01 0.0018
2020-05-11 2020-03-31 13F KRYSTAL BIOTECH COM 501147102 467,393 11,168 20,210 1,774.8449
2020-02-06 2019-12-31 13F KRYSTAL BIOTECH COM 501147102 456,225 -10,219 -2.19 25,266 55.99 0.0017
2019-11-14 2019-09-30 13F KRYSTAL BIOTECH COM 501147102 466,444 308,298 194.95 16,197 154.31 0.0012
2019-08-14 2019-06-30 13F KRYSTAL BIOTECH COM 501147102 158,146 151,143 2,158.26 6,369 2,669.13 0.0005
2019-05-15 2019-03-31 13F KRYSTAL BIOTECH COM 501147102 7,003 7,003 230 0.0000
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.