Spyre Therapeutics, Inc.
DE ˙ DB ˙ US00773J2024
60,00 € ↑0,50 (0,84%)
2026-06-03
DEL PRIS
SecurityDE:3920 / Spyre Therapeutics, Inc.
InstitutionState Street Corp
Latest Disclosed Ownership2,607,031 shares
Latest Disclosed Value $ 131,498,644
State Street Corp reports 15.21% increase in ownership of 3920 / Spyre Therapeutics, Inc.

On May 15, 2026 - State Street Corp filed a 13F-HR form disclosing ownership of 2,607,031 shares of Spyre Therapeutics, Inc. (DE:3920) valued at $103,238,428 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 2,262,839 shares of Spyre Therapeutics, Inc.. This represents a change in shares of 15.21% during the quarter. The current value of the position is $156,421,860 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F SPYRE THERAPEUTICS COM NEW 00773J202 2,607,031 344,192 15.21 131,499 77.39 0.0045
2026-02-13 2025-12-31 13F SPYRE THERAPEUTICS COM NEW 00773J202 2,262,839 477,633 26.76 74,131 147.76 0.0025
2025-11-14 2025-09-30 13F SPYRE THERAPEUTICS COM NEW 00773J202 1,785,206 189,915 11.90 29,920 25.29 0.0010
2025-08-14 2025-06-30 13F SPYRE THERAPEUTICS COM NEW 00773J202 1,595,291 -101,824 -6.00 23,882 -12.79 0.0009
2025-05-15 2025-03-31 13F SPYRE THERAPEUTICS COM NEW 00773J202 1,697,115 16,179 0.96 27,383 -30.03 0.0011
2025-02-14 2024-12-31 13F SPYRE THERAPEUTICS COM NEW 00773J202 1,680,936 139,381 9.04 39,132 -13.69 0.0015
2024-11-14 2024-09-30 13F SPYRE THERAPEUTICS COM NEW 00773J202 1,541,555 131,896 9.36 45,337 36.80 0.0018
2024-08-14 2024-06-30 13F SPYRE THERAPEUTICS COM NEW 00773J202 1,409,659 1,275,233 948.65 33,141 550.08 0.0014
2024-05-15 2024-03-31 13F SPYRE THERAPEUTICS COM NEW 00773J202 134,426 134,426 5,099 0.0002
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.