Iovance Biotherapeutics, Inc.
DE ˙ DB ˙ US4622601007
3,31 € ↓ -0,17 (-4,89%)
2026-06-04
DEL PRIS
SecurityDE:2LB / Iovance Biotherapeutics, Inc.
InstitutionMorgan Stanley
Latest Disclosed Ownership6,201,282 shares
Latest Disclosed Value $ 21,766,499
Morgan Stanley reports 32.53% decrease in ownership of 2LB / Iovance Biotherapeutics, Inc.

On May 15, 2026 - Morgan Stanley filed a 13F-HR form disclosing ownership of 6,201,282 shares of Iovance Biotherapeutics, Inc. (DE:2LB) valued at $17,788,377 USD as of March 31, 2026. The entity filed a previous 13F-HR/A on May 27, 2026 disclosing 9,191,840 shares of Iovance Biotherapeutics, Inc.. This represents a change in shares of -32.53% during the quarter. The current value of the position is $20,526,243 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 6,201,282 -2,990,558 -32.53 21,766 -13.26 0.0013
2026-05-27 2025-12-31 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 9,191,840 3,610,277 64.68 25,094 107.19 0.0015
2026-02-13 2025-12-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 9,191,840 3,610,277 25,094 0.0015
2026-05-27 2025-09-30 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 5,581,563 -869,370 -13.48 12,112 9.16 0.0007
2025-11-14 2025-09-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 5,581,563 -869,370 12,112 0.0007
2025-08-15 2025-06-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 6,450,933 2,432,559 60.54 11,096 -17.08 0.0007
2025-05-15 2025-03-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 4,018,374 58,535 1.48 13,381 -54.33 0.0010
2025-05-15 2024-12-31 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 3,959,839 1,811,265 84.30 29,303 45.24 0.0021
2025-02-14 2024-12-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 3,959,839 1,811,265 29,303 0.0021
2025-05-14 2024-09-30 13F/A-2 IOVANCE BIOTHERAPEUTICS COM 462260100 2,148,574 -674,289 -23.89 20,175 -10.88 0.0015
2025-02-14 2024-09-30 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 2,148,574 -674,289 20,175 0.0015
2024-11-14 2024-09-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 2,148,574 -674,289 20,175 0.0002
2025-05-14 2024-06-30 13F/A-2 IOVANCE BIOTHERAPEUTICS COM 462260100 2,822,863 131,842 4.90 22,639 -43.23 0.0018
2024-10-17 2024-06-30 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 2,822,863 131,842 22,639 0.0018
2024-08-14 2024-06-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 2,822,863 131,842 22,639 0.0018
2024-10-17 2024-03-31 13F/A-2 IOVANCE BIOTHERAPEUTICS COM 462260100 2,691,021 -1,024,524 -27.57 39,881 32.02 0.0032
2024-08-16 2024-03-31 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 2,691,021 -1,024,524 39,881 0.0032
2024-05-15 2024-03-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 2,691,021 -1,024,524 39,881 0.0032
2024-08-16 2023-12-31 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 3,715,545 1,233,420 49.69 30,207 167.48 0.0027
2024-02-13 2023-12-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 3,715,545 1,233,420 30,207 0.0027
2023-11-15 2023-09-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 2,482,125 -1,015,483 -29.03 11,294 -54.14 0.0011
2023-08-14 2023-06-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 3,497,608 -4,195,083 -54.53 24,623 -47.61 0.0024
2023-05-15 2023-03-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 7,692,691 2,722,822 54.79 47,002 48.01 0.0050
2023-02-14 2022-12-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 4,969,869 3,921,869 374.22 31,757 216.30 0.0036
2022-11-14 2022-09-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 1,048,000 -402,057 -27.73 10,040 -37.28 0.0014
2022-10-27 2022-06-30 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 1,450,057 891,307 159.52 16,008 72.09 0.0021
2022-08-15 2022-06-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 1,450,057 891,307 16,008 0.0021
2022-10-27 2022-03-31 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 558,750 305,175 120.35 9,302 92.15 0.0013
2022-05-13 2022-03-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 558,750 305,175 9,302 0.0013
2022-02-14 2021-12-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 253,575 -65,284 -20.47 4,841 -38.43 0.0006
2021-11-15 2021-09-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 318,859 79,262 33.08 7,863 26.11 0.0011
2021-08-23 2021-06-30 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 239,597 -313,717 -56.70 6,235 -64.41 0.0008
2021-08-16 2021-06-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 239,597 -313,717 6,235 0.0002
2021-05-17 2021-03-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 553,314 363,661 191.75 17,517 99.03 0.0026
2021-02-16 2020-12-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 189,653 81,368 75.14 8,801 146.87 0.0014
2020-11-13 2020-09-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 108,285 -45,697 -29.68 3,565 -15.66 0.0007
2020-08-14 2020-06-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 153,982 53,124 52.67 4,227 39.97 0.0009
2020-05-26 2020-03-31 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 100,858 -88,072 -46.62 3,020 -42.26 0.0008
2020-05-15 2020-03-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 100,858 -88,072 3,020 231.9990
2020-02-14 2019-12-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 188,930 -104,637 -35.64 5,230 -2.13 0.0012
2019-11-14 2019-09-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 293,567 256,249 686.66 5,344 484.04 0.0014
2019-08-14 2019-06-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 37,318 -54,190 -59.22 915 5.17 0.0002
2019-05-15 2019-03-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 91,508 -133,365 -59.31 870 -56.28 0.0002
2019-02-14 2018-12-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 224,873 74,781 49.82 1,990 17.89 0.0006
2019-04-23 2018-09-30 13F/A-2 IOVANCE BIOTHERAPEUTICS COM 462260100 150,092 -117,863 -43.99 1,688 -50.79 0.0004
2018-11-20 2018-09-30 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 150,092 0 1,688 0.0004
2018-11-14 2018-09-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 150,092 -117,863 1,688
2019-04-23 2018-06-30 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 267,955 107,996 67.51 3,430 26.90 0.0009
2018-08-14 2018-06-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 267,955 107,996 3,430
2019-04-23 2018-03-31 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 159,959 33,277 26.27 2,703 166.83 0.0008
2018-05-14 2018-03-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 159,959 33,277 2,703
2019-04-23 2017-12-31 13F/A-1 IOVANCE BIOTHERAPEUTICS COM 462260100 126,682 40,807 47.52 1,013 52.10 0.0003
2018-02-14 2017-12-31 13F IOVANCE BIOTHERAPEUTICS COM 462260100 126,682 40,807 1,013
2017-11-14 2017-09-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 85,875 35,173 69.37 666 78.55 0.0002
2017-08-11 2017-06-30 13F IOVANCE BIOTHERAPEUTICS COM 462260100 50,702 -32,986 -39.42 373 -40.22 0.0001
2017-05-22 2017-03-31 13F/A-1 LION BIOTECHNOLOGIES COM 53619R102 83,688 -92,925 -52.62 624 -49.19 0.0002
2017-05-12 2017-03-31 13F LION BIOTECHNOLOGIES COM 53619R102 83,688 624
2017-02-22 2016-12-31 13F/A-1 LION BIOTECHNOLOGIES COM 53619R102 176,613 148,279 523.33 1,228 424.79 0.0004
2017-02-13 2016-12-31 13F LION BIOTECHNOLOGIES COM 53619R102 176,613 1,228
2016-11-10 2016-09-30 13F LION BIOTECHNOLOGIES COM 53619R102 28,334 -28,647 -50.27 234 -49.35 0.0001
2016-08-12 2016-06-30 13F LION BIOTECHNOLOGIES COM 53619R102 56,981 -9,055 -13.71 462 37.50 0.0002
2016-05-12 2016-03-31 13F LION BIOTECHNOLOGIES COM 53619R102 66,036 3,455 5.52 336 -30.43 0.0001
2016-02-09 2015-12-31 13F LION BIOTECHNOLOGIES COM 53619R102 62,581 21,248 51.41 483 102.94 0.0002
2016-02-08 2015-09-30 13F/A-1 LION BIOTECHNOLOGIES COM 53619R102 41,333 27,414 196.95 238 85.94 0.0001
2015-11-09 2015-09-30 13F LION BIOTECHNOLOGIES COM 53619R102 41,333 238
2015-08-12 2015-06-30 13F LION BIOTECHNOLOGIES COM 53619R102 13,919 410 3.04 128 -21.95 0.0000
2015-05-14 2015-03-31 13F LION BIOTECHNOLOGIES COM 53619R102 13,509 13,509 164 0.0001
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.