Prothena Corporation plc
DE ˙ DB ˙ IE00B91XRN20
7,74 € ↑0,39 (5,30%)
2026-06-04
DEL PRIS
SecurityDE:0PT / Prothena Corporation plc
InstitutionRenaissance Technologies Llc
ManagerJames Simons
Latest Disclosed Ownership607,515 shares
Latest Disclosed Value $ 5,905,046
Renaissance Technologies Llc reports 39.49% increase in ownership of 0PT / Prothena Corporation plc

On May 14, 2026 - Renaissance Technologies Llc filed a 13F-HR form disclosing ownership of 607,515 shares of Prothena Corporation plc (DE:0PT) valued at $4,981,623 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 435,515 shares of Prothena Corporation plc. This represents a change in shares of 39.49% during the quarter. The current value of the position is $4,704,596 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F PROTHENA CORP SHS G72800108 607,515 172,000 39.49 5,905 41.98 0.0092
2026-02-12 2025-12-31 13F PROTHENA CORP SHS G72800108 435,515 64,215 17.29 4,159 14.79 0.0065
2025-11-13 2025-09-30 13F PROTHENA CORP SHS G72800108 371,300 281,100 311.64 3,624 562.34 0.0048
2025-08-13 2025-06-30 13F PROTHENA CORP SHS G72800108 90,200 -149,700 -62.40 548 -81.57 0.0007
2025-05-14 2025-03-31 13F PROTHENA CORP SHS G72800108 239,900 38,000 18.82 2,969 6.15 0.0045
2025-02-13 2024-12-31 13F PROTHENA CORP SHS G72800108 201,900 19,100 10.45 2,796 -8.57 0.0041
2024-11-13 2024-09-30 13F PROTHENA CORP SHS G72800108 182,800 -146,700 -44.52 3,058 -55.03 0.0046
2024-08-09 2024-06-30 13F PROTHENA CORP SHS G72800108 329,500 -60,200 -15.45 6,801 75,455.56 0.0115
2024-05-13 2024-03-31 13F PROTHENA CORP SHS G72800108 389,700 53,900 16.05 10 -25.00 0.0152
2024-02-13 2023-12-31 13F PROTHENA CORP SHS G72800108 335,800 75,200 28.86 12 0.00 0.0189
2023-11-14 2023-09-30 13F PROTHENA CORP SHS G72800108 260,600 -63,200 -19.52 13 -45.45 0.0214
2023-08-11 2023-06-30 13F PROTHENA CORP SHS G72800108 323,800 -83,500 -20.50 22 15.79 0.0319
2023-05-12 2023-03-31 13F PROTHENA CORP SHS G72800108 407,300 -67,600 -14.23 20 -32.14 0.0262
2023-02-13 2022-12-31 13F PROTHENA CORP SHS G72800108 474,900 -162,000 -25.44 29 -99.93 0.0391
2022-11-14 2022-09-30 13F PROTHENA CORP SHS G72800108 636,900 -49,100 -7.16 38,615 107.33 0.0546
2022-08-12 2022-06-30 13F PROTHENA CORP SHS G72800108 686,000 291,800 74.02 18,625 29.20 0.0220
2022-05-13 2022-03-31 13F PROTHENA CORP SHS G72800108 394,200 127,400 47.75 14,416 9.38 0.0169
2022-02-11 2021-12-31 13F PROTHENA CORP SHS G72800108 266,800 9,600 3.73 13,180 -28.06 0.0164
2021-11-12 2021-09-30 13F PROTHENA CORP SHS G72800108 257,200 18,900 7.93 18,320 49.54 0.0237
2021-08-13 2021-06-30 13F PROTHENA CORP SHS G72800108 238,300 -50,700 -17.54 12,251 68.75 0.0153
2021-05-13 2021-03-31 13F PROTHENA CORP SHS G72800108 289,000 -25,000 -7.96 7,260 92.52 0.0090
2021-02-10 2020-12-31 13F PROTHENA CORP SHS G72800108 314,000 48,800 18.40 3,771 42.36 0.0041
2020-11-13 2020-09-30 13F PROTHENA CORP SHS G72800108 265,200 -122,762 -31.64 2,649 -34.72 0.0026
2020-08-13 2020-06-30 13F PROTHENA CORP SHS G72800108 387,962 303,062 356.96 4,058 346.92 0.0035
2020-05-14 2020-03-31 13F PROTHENA CORP SHS G72800108 84,900 15,800 22.87 908 -17.00 0.0009
2020-02-13 2019-12-31 13F PROTHENA CORP SHS G72800108 69,100 24,100 53.56 1,094 209.92 0.0008
2019-11-13 2019-09-30 13F PROTHENA CORP SHS G72800108 45,000 45,000 353 0.0003
2019-08-12 2019-06-30 13F PROTHENA CORP SHS G72800108 0 -12,800 -100.00 0 -100.00
2019-05-14 2019-03-31 13F PROTHENA CORP SHS G72800108 12,800 12,800 155 0.0001
2019-02-12 2018-12-31 13F PROTHENA CORP SHS G72800108 0 -57,400 -100.00 0 -100.00
2018-11-13 2018-09-30 13F PROTHENA CORP SHS G72800108 57,400 57,400 751 0.0008
2018-05-14 2018-03-31 13F PROTHENA CORP SHS G72800108 0 -42,700 -100.00 0 -100.00
2018-02-13 2017-12-31 13F PROTHENA CORP SHS G72800108 42,700 42,700 1,601 0.0018
2016-05-13 2016-03-31 13F PROTHENA CORP SHS G72800108 0 -90,600 -100.00 0 -100.00
2016-02-11 2015-12-31 13F PROTHENA CORP SHS G72800108 90,600 54,200 148.90 6,171 274.00 0.0134
2015-11-12 2015-09-30 13F PROTHENA CORP SHS G72800108 36,400 36,400 -59.82 1,650 -73.26 0.0039
2015-02-13 2014-12-31 13F PROTHENA CORP SHS G72800108 0 -17,300 -100.00 0 -100.00
2014-11-12 2014-09-30 13F PROTHENA CORP SHS G72800108 17,300 -34,600 -66.67 383 -67.26 0.0010
2014-08-13 2014-06-30 13F PROTHENA CORP SHS G72800108 51,900 -27,212 -34.40 1,170 -61.40 0.0027
2014-05-14 2014-03-31 13F PROTHENA CORP SHS G72800108 79,112 14,512 22.46 3,031 76.94 0.0073
2014-02-14 2013-12-31 13F PROTHENA CORP SHS G72800108 64,600 64,600 1,713 0.0041
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.