INSV / Insite Vision Inc - SEC-arkivering, Årsberetning, Fuldmagtserklæring

Insite Vision Inc
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CIK 802724
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Insite Vision Inc
SEC Filings (Chronological Order)
Denne side giver en komplet, kronologisk liste over SEC-arkiveringer, eksklusive ejerskabsregistreringer, som vi leverer andre steder.
November 2, 2015 POS AM

INSV POS AM

POS AM As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 S-8 POS

INSV FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 POS AM

INSV POS AM

POS AM As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION INSITE VISION INCORPORATION ARTICLE I

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF INSITE VISION INCORPORATION ARTICLE I Name The name of the corporation is InSite Vision Incorporated (the “Corporation”). ARTICLE II Registered Office and Registered Agent The address of the registered office of the Corporation in the State of Delaware is The Prentice-Hall Corporation System, Inc., 2711 Centerville Road, Suite 400, N

November 2, 2015 POS AM

INSV POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-1

POS AM 1 d80415dposam.htm POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-1 As filed with the Securities and Exchange Commission on November 2, 2015 Registration No. 333-205644 Registration No. 333-201052 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 Post-Effective Amendment No. 1 to Form S-1 Registration Statement

November 2, 2015 S-8 POS

INSV FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 S-8 POS

INSV FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 S-8 POS

INSV FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 S-8 POS

INSV FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 S-8 POS

INSV FORM S-8 POS

As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 S-8 POS

INSV FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 15-12G

INSV FORM 15-12G

Form 15-12G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number: 000-22332 INSITE VISION INCORPORATED (Exact name of registrant a

November 2, 2015 S-8 POS

INSV FORM S-8 POS

As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 S-8 POS

INSV FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 POS AM

INSV POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-1

Post-Effective Amendment No. 1 to Form S-1 As filed with the Securities and Exchange Commission on November 2, 2015 Registration No. 333-205644 Registration No. 333-201052 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 Post-Effective Amendment No. 1 to Form S-1 Registration Statement No. 333-205644 Post-Effec

November 2, 2015 8-K

Changes in Control of Registrant, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 28, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Co

November 2, 2015 POS AM

INSV POS AM

POS AM As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 S-8 POS

INSV FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 POS AM

INSV POS AM

POS AM As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 S-8 POS

INSV FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 S-8 POS

INSV FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 EX-3.2

BYLAWS INSITE VISION INCORPORATED Table of Contents Section Page ARTICLE I OFFICES Section 1.01. Registered Office 1 Section 1.02. Other Offices 1 ARTICLE II MEETINGS OF STOCKHOLDERS Section 2.01. Annual Meetings 1 Section 2.02. Special Meetings 1 Se

EX-3.2 3 d82422dex32.htm EX-3.2 Exhibit 3.2 BYLAWS OF INSITE VISION INCORPORATED Table of Contents Section Page ARTICLE I OFFICES Section 1.01. Registered Office 1 Section 1.02. Other Offices 1 ARTICLE II MEETINGS OF STOCKHOLDERS Section 2.01. Annual Meetings 1 Section 2.02. Special Meetings 1 Section 2.03. Notice of Meetings 1 Section 2.04. Waiver of Notice 2 Section 2.05. Adjournments 2 Section

November 2, 2015 S-8 POS

INSV FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 POS AM

INSV POS AM

POS AM As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 S-8 POS

INSV FORM S-8 POS

Form S-8 POS As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 POS AM

INSV POS AM

POS AM As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

November 2, 2015 POS AM

INSV POS AM

POS AM As filed with the Securities and Exchange Commission on November 2, 2015 Registration No.

October 28, 2015 SC 14D9/A

INSV SC 14D9/A

SC 14D9/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (RULE 14d-101) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 2) INSITE VISION INCORPORATED (Name of Subject Company) INSITE VISION INCORPORATED (Name of Person Filing Statement) Common Stock, par value $0.01 per share (Title of Class of Securities)

October 2, 2015 PREM14A

INSV PREM14A

PREM14A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

September 30, 2015 SC 14D9/A

INSV SC 14D9/A

SC 14D9/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (RULE 14d-101) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 (Amendment No. 1) INSITE VISION INCORPORATED (Name of Subject Company) INSITE VISION INCORPORATED (Name of Person Filing Statement) Common Stock, par value $0.01 per share (Title of Class of Securities)

September 29, 2015 EX-99.(A)(2)

September 29, 2015

EX-99.(A)(2) Exhibit (a)(2) September 29, 2015 Dear Stockholder: On September 15, 2015, InSite Vision Incorporated (?InSite?) entered into an Agreement and Plan of Merger, as amended and restated on September 28, 2015 (the ?Merger Agreement?), with Ranbaxy, Inc., a Delaware corporation (?Ranbaxy?) and an indirect wholly owned subsidiary of Sun Pharmaceutical Industries Ltd., a global pharmaceutica

September 29, 2015 EX-99.(E)(7)

INTERCREDITOR AGREEMENT

Exhibit (e)(7) INTERCREDITOR AGREEMENT Intercreditor Agreement (this “Agreement”), dated as of September 15, 2015, among RANBAXY, INC.

September 29, 2015 SC 14D9

INSV SC 14D9

SC 14D9 Table of Contents SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 (RULE 14d-101) Solicitation/Recommendation Statement Under Section 14(d)(4) of the Securities Exchange Act of 1934 INSITE VISION INCORPORATED (Name of Subject Company) INSITE VISION INCORPORATED (Name of Person Filing Statement) Common Stock, par value $0.01 per share (Title of Class of Securities) 4

September 28, 2015 SC14D9C

INSV SC14D9C

SC14D9C UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D?9 SOLICITATION/ RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 INSITE VISION INCORPORATED (Name of Subject Company (issuer)) INSITE VISION INCORPORATED (Names of Persons Filing Statement) Common Stock, par value $0.01 per share (Title of Class of Securities) 45766010

September 28, 2015 DEFA14A

INSV 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 28, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (

September 28, 2015 EX-2.1

AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, RANBAXY, INC. THEA ACQUISITION CORP. Dated as of September 28, 2015 TABLE OF CONTENTS Page ARTICLE I THE OFFER Section 1.1 The Offer 2 Section 1.2 Company Acti

EX-2.1 Exhibit 2.1 EXECUTION COPY AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, RANBAXY, INC. and THEA ACQUISITION CORP. Dated as of September 28, 2015 TABLE OF CONTENTS Page ARTICLE I THE OFFER Section 1.1 The Offer 2 Section 1.2 Company Actions 6 Section 1.3 Directors 7 Section 1.4 Top-Up Option 8 Section 1.5 Merger Without Meeting of Stockholders 10

September 28, 2015 EX-2.1

AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, RANBAXY, INC. THEA ACQUISITION CORP. Dated as of September 28, 2015 TABLE OF CONTENTS Page ARTICLE I THE OFFER Section 1.1 The Offer 2 Section 1.2 Company Acti

EX-2.1 Exhibit 2.1 EXECUTION COPY AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, RANBAXY, INC. and THEA ACQUISITION CORP. Dated as of September 28, 2015 TABLE OF CONTENTS Page ARTICLE I THE OFFER Section 1.1 The Offer 2 Section 1.2 Company Actions 6 Section 1.3 Directors 7 Section 1.4 Top-Up Option 8 Section 1.5 Merger Without Meeting of Stockholders 10

September 28, 2015 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 28, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (

September 15, 2015 SC14D9C

INSV SC14D9C

SC14D9C UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/ RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 INSITE VISION INCORPORATED (Name of Subject Company (issuer)) INSITE VISION INCORPORATED (Names of Persons Filing Statement) Common Stock, par value $0.01 per share (Title of Class of Securities) 45766010

September 15, 2015 DEFA14A

INSV DEFA14A

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

September 15, 2015 EX-10.1

INSITE VISION INCORPORATED SECURED NOTE

EX-10.1 Exhibit 10.1 INSITE VISION INCORPORATED SECURED NOTE USD$11,914,194.52 September 15, 2015 FOR VALUE RECEIVED, InSite Vision Incorporated, a Delaware corporation (the “Maker”), promises to pay to the order of Ranbaxy, Inc. (the “Holder”), at Acme Plaza, Andheri Kurla Road, Andheri (East), Mumbai, Maharashtra, India, 400059, the principal sum of $11,914,194.52 (or such lesser outstanding amo

September 15, 2015 EX-99.1

InSite Vision and Sun Pharma Enter into Merger Agreement Shareholders Will Receive $0.35 per Share in Cash at Closing InSite Terminates Merger Agreement with QLT Inc.

EX-99.1 Exhibit 99.1 InSite Vision and Sun Pharma Enter into Merger Agreement Shareholders Will Receive $0.35 per Share in Cash at Closing InSite Terminates Merger Agreement with QLT Inc. ALAMEDA, Calif. ? September 15, 2015 ? InSite Vision Inc. (OTCBB: INSV) today announced that InSite and a subsidiary of Sun Pharmaceutical Industries Ltd. (Sun Pharma) have entered into a merger agreement under w

September 15, 2015 EX-99.1

InSite Vision and Sun Pharma Enter into Merger Agreement Shareholders Will Receive $0.35 per Share in Cash at Closing InSite Terminates Merger Agreement with QLT Inc.

Exhibit 99.1 InSite Vision and Sun Pharma Enter into Merger Agreement Shareholders Will Receive $0.35 per Share in Cash at Closing InSite Terminates Merger Agreement with QLT Inc. ALAMEDA, Calif. — September 15, 2015 — InSite Vision Inc. (OTCBB: INSV) today announced that InSite and a subsidiary of Sun Pharmaceutical Industries Ltd. (Sun Pharma) have entered into a merger agreement under which an

September 15, 2015 EX-10.3

INTELLECTUAL PROPERTY SECURITY AGREEMENT

EX-10.3 Exhibit 10.3 Execution Version INTELLECTUAL PROPERTY SECURITY AGREEMENT This Intellectual Property Security Agreement is entered into as of September 15, 2015, is between Ranbaxy, Inc. (the ?Secured Party?) and InSite Vision Incorporated, a Delaware corporation (the ?Grantor?). RECITALS A. Pursuant to the Secured Note dated as of September 15, 2015 (as amended, restated, supplemented or ot

September 15, 2015 EX-10.2

SECURITY AGREEMENT

EX-10.2 Exhibit 10.2 EXECUTION VERSION SECURITY AGREEMENT This Security Agreement dated as of September 15, 2015 (this ?Agreement?), is made by InSite Vision Incorporated, a Delaware corporation (the ?Company?), in favor of Ranbaxy, Inc. (the ?Secured Party?). PRELIMINARY STATEMENTS: A. Pursuant to the Secured Note dated as of September 15, 2015 (as amended, restated, supplemented or otherwise mod

September 15, 2015 EX-10.4

FORM OF AMENDMENT, WAIVER AND CONSENT

Exhibit 10.4 FORM OF AMENDMENT, WAIVER AND CONSENT TO: INSITE VISION INCORPORATED (the “Corporation”) RE: 12% SECURED SENIOR NOTES OF THE CORPORATION WHEREAS: A. The undersigned (the “Holder”) is the holder of a 12% senior secured notes in the aggregate principal amount of US$ (the “Holder Notes”, and together with all other notes issued pursuant to the Purchase Agreement (as defined below), the “

September 15, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 9 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock

424(b)(3) Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-205644 PROSPECTUS SUPPLEMENT NO. 9 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock This Prospectus Supplement No. 9 supplements our Prospectus, dated July 16, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 3,464

September 15, 2015 SC14D9C

INSV SC14D9C

SC14D9C UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14D-9 SOLICITATION/ RECOMMENDATION STATEMENT UNDER SECTION 14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934 INSITE VISION INCORPORATED (Name of Subject Company (issuer)) INSITE VISION INCORPORATED (Names of Persons Filing Statement) Common Stock, par value $0.01 per share (Title of Class of Securities) 45766010

September 15, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 14 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424(b)(3) Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS SUPPLEMENT NO. 14 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This Prospectus Supplement No. 14 supplements our Prospectus, dated March 17, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 5

September 15, 2015 EX-10.2

SECURITY AGREEMENT

EX-10.2 Exhibit 10.2 EXECUTION VERSION SECURITY AGREEMENT This Security Agreement dated as of September 15, 2015 (this ?Agreement?), is made by InSite Vision Incorporated, a Delaware corporation (the ?Company?), in favor of Ranbaxy, Inc. (the ?Secured Party?). PRELIMINARY STATEMENTS: A. Pursuant to the Secured Note dated as of September 15, 2015 (as amended, restated, supplemented or otherwise mod

September 15, 2015 EX-2.1

AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, RANBAXY, INC. THEA ACQUISITION CORP. Dated as of September 15, 2015 TABLE OF CONTENTS Page ARTICLE I THE OFFER Section 1.1 The Offer 2 Section 1.2 Company Actions 5 Section 1.3 Dir

Exhibit 2.1 EXECUTION COPY AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, RANBAXY, INC. and THEA ACQUISITION CORP. Dated as of September 15, 2015 TABLE OF CONTENTS Page ARTICLE I THE OFFER Section 1.1 The Offer 2 Section 1.2 Company Actions 5 Section 1.3 Directors 5 Section 1.4 Top-Up Option 6 Section 1.5 Merger Without Meeting of Stockholders 8 ARTICLE II THE MERGER Section

September 15, 2015 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Financial Statements and Exhibits, Triggering Events That Accelerate or Increase a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 15, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (

September 15, 2015 DEFA14A

INSV 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 15, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (

September 15, 2015 EX-10.1

INSITE VISION INCORPORATED SECURED NOTE

Exhibit 10.1 INSITE VISION INCORPORATED SECURED NOTE USD$11,914,194.52 September 15, 2015 FOR VALUE RECEIVED, InSite Vision Incorporated, a Delaware corporation (the “Maker”), promises to pay to the order of Ranbaxy, Inc. (the “Holder”), at Acme Plaza, Andheri Kurla Road, Andheri (East), Mumbai, Maharashtra, India, 400059, the principal sum of $11,914,194.52 (or such lesser outstanding amount adva

September 15, 2015 EX-10.3

INTELLECTUAL PROPERTY SECURITY AGREEMENT

EX-10.3 Exhibit 10.3 Execution Version INTELLECTUAL PROPERTY SECURITY AGREEMENT This Intellectual Property Security Agreement is entered into as of September 15, 2015, is between Ranbaxy, Inc. (the ?Secured Party?) and InSite Vision Incorporated, a Delaware corporation (the ?Grantor?). RECITALS A. Pursuant to the Secured Note dated as of September 15, 2015 (as amended, restated, supplemented or ot

September 15, 2015 EX-10.4

FORM OF AMENDMENT, WAIVER AND CONSENT

EX-10.4 Exhibit 10.4 FORM OF AMENDMENT, WAIVER AND CONSENT TO: INSITE VISION INCORPORATED (the ?Corporation?) RE: 12% SECURED SENIOR NOTES OF THE CORPORATION WHEREAS: A. The undersigned (the ?Holder?) is the holder of a 12% senior secured notes in the aggregate principal amount of US$ (the ?Holder Notes?, and together with all other notes issued pursuant to the Purchase Agreement (as defined below

September 15, 2015 EX-2.1

AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, RANBAXY, INC. THEA ACQUISITION CORP. Dated as of September 15, 2015 TABLE OF CONTENTS Page ARTICLE I THE OFFER Section 1.1 The Offer 2 Section 1.2 Company Actions 5 Section 1.3 Dir

EX-2.1 Exhibit 2.1 EXECUTION COPY AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, RANBAXY, INC. and THEA ACQUISITION CORP. Dated as of September 15, 2015 TABLE OF CONTENTS Page ARTICLE I THE OFFER Section 1.1 The Offer 2 Section 1.2 Company Actions 5 Section 1.3 Directors 5 Section 1.4 Top-Up Option 6 Section 1.5 Merger Without Meeting of Stockholders 8 ARTICLE II THE MERGER

September 15, 2015 EX-99.1

InSite Vision and Sun Pharma Enter into Merger Agreement Shareholders Will Receive $0.35 per Share in Cash at Closing InSite Terminates Merger Agreement with QLT Inc.

EX-99.1 7 d16995dex991.htm EX-99.1 Exhibit 99.1 InSite Vision and Sun Pharma Enter into Merger Agreement Shareholders Will Receive $0.35 per Share in Cash at Closing InSite Terminates Merger Agreement with QLT Inc. ALAMEDA, Calif. — September 15, 2015 — InSite Vision Inc. (OTCBB: INSV) today announced that InSite and a subsidiary of Sun Pharmaceutical Industries Ltd. (Sun Pharma) have entered into

September 8, 2015 425

Qlt 8-K (Prospectus)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 4, 2015 QLT Inc. (Exact Name of Registrant as specified in its charter) British Columbia, Canada 000-17082 N/A (State or Other Jurisdiction of Incorporation) (Commission Fil

September 8, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 13 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424B3 1 d180081d424b3.htm 424(B)(3) Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS SUPPLEMENT NO. 13 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This Prospectus Supplement No. 13 supplements our Prospectus, dated March 17, 2015, and relates to the resale by the selling stockholders identified in the Prospectus

September 8, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 8 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock

424(b)(3) Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-205644 PROSPECTUS SUPPLEMENT NO. 8 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock This Prospectus Supplement No. 8 supplements our Prospectus, dated July 16, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 3,464

September 8, 2015 EX-99.1

QLT PROVIDES ADDITIONAL UPDATE ON ITS PROPOSED ACQUISITION OF INSITE VISION INCORPORATED

Exhibit 99.1 News release QLT PROVIDES ADDITIONAL UPDATE ON ITS PROPOSED ACQUISITION OF INSITE VISION INCORPORATED For Immediate Release September 4, 2015 VANCOUVER, CANADA ? QLT Inc. (NASDAQ: QLTI; TSX: QLT) (?QLT? or the ?Company?) announces that it has been advised by InSite Vision Incorporated (?InSite?) that the board of directors of InSite has determined, in good faith and after consultation

September 4, 2015 425

Qlt 8-K (Prospectus)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): September 3, 2015 QLT Inc. (Exact Name of Registrant as specified in its charter) British Columbia, Canada 000-17082 N/A (State or Other Jurisdiction of Incorporation) (Commission Fil

September 4, 2015 EX-99.1

InSite Vision Determines that an Unsolicited Offer from a Global Pharmaceutical Company to Acquire InSite for $0.35 per Share in Cash Constitutes a “Company Superior Proposal” Bidder Favorably Concludes Due Diligence on Recent BromSite™ Patent Lawsui

EX-99.1 2 d55825dex991.htm EX-99.1 Exhibit 99.1 InSite Vision Determines that an Unsolicited Offer from a Global Pharmaceutical Company to Acquire InSite for $0.35 per Share in Cash Constitutes a “Company Superior Proposal” Bidder Favorably Concludes Due Diligence on Recent BromSite™ Patent Lawsuit ALAMEDA, Calif. – September 4, 2015 – InSite Vision Inc. (OTCBB: INSV) today announced that InSite’s

September 4, 2015 8-K

Financial Statements and Exhibits, Other Events

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 4, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporatio

September 4, 2015 EX-99.1

InSite Vision Determines that an Unsolicited Offer from a Global Pharmaceutical Company to Acquire InSite for $0.35 per Share in Cash Constitutes a “Company Superior Proposal” Bidder Favorably Concludes Due Diligence on Recent BromSite™ Patent Lawsui

EX-99.1 2 d55825dex991.htm EX-99.1 Exhibit 99.1 InSite Vision Determines that an Unsolicited Offer from a Global Pharmaceutical Company to Acquire InSite for $0.35 per Share in Cash Constitutes a “Company Superior Proposal” Bidder Favorably Concludes Due Diligence on Recent BromSite™ Patent Lawsuit ALAMEDA, Calif. – September 4, 2015 – InSite Vision Inc. (OTCBB: INSV) today announced that InSite’s

September 4, 2015 EX-99.1

QLT PROVIDES FURTHER UPDATE ON ITS PROPOSED ACQUISITION OF INSITE VISION INCORPORATED

Exhibit 99.1 News release QLT PROVIDES FURTHER UPDATE ON ITS PROPOSED ACQUISITION OF INSITE VISION INCORPORATED For Immediate Release September 3, 2015 VANCOUVER, CANADA ? QLT Inc. (NASDAQ: QLTI; TSX: QLT) (?QLT? or the ?Company?) announces that it has been advised by InSite Vision Incorporated (?InSite?) that InSite has received a second unsolicited offer from the multi-national pharmaceutical co

September 4, 2015 DEFA14A

INSV FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 4, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporatio

September 3, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 7 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock

424B3 Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-205644 PROSPECTUS SUPPLEMENT NO. 7 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock This Prospectus Supplement No. 7 supplements our Prospectus, dated July 16, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 3,464,456

September 3, 2015 EX-99.1

InSite Vision Receives Second Unsolicited Acquisition Proposal for $0.35 per Share from a Global Pharmaceutical Company

EX-99.1 2 d25804dex991.htm EX-99.1 Exhibit 99.1 For Immediate Release InSite Vision Receives Second Unsolicited Acquisition Proposal for $0.35 per Share from a Global Pharmaceutical Company ALAMEDA, Calif. – September 3, 2015 — InSite Vision Inc. (OTCBB: INSV) today announced that the Company has received a second unsolicited proposal from a global pharmaceutical company to acquire all outstanding

September 3, 2015 8-K

Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 2, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (C

September 3, 2015 8-K

INSV 8-K (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 3, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (C

September 3, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 12 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424B3 Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS SUPPLEMENT NO. 12 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This Prospectus Supplement No. 12 supplements our Prospectus, dated March 17, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 5,078

September 3, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 6 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock

424(b)(3) Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-205644 PROSPECTUS SUPPLEMENT NO. 6 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock This Prospectus Supplement No. 6 supplements our Prospectus, dated July 16, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 3,464

September 3, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 11 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424(b)(3) Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS SUPPLEMENT NO. 11 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This Prospectus Supplement No. 11 supplements our Prospectus, dated March 17, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 5

September 3, 2015 425

INSV 8-K (Prospectus)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 3, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Commi

September 3, 2015 DEFA14A

INSV 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 2, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (C

September 3, 2015 EX-99.1

InSite Vision Receives Second Unsolicited Acquisition Proposal for $0.35 per Share from a Global Pharmaceutical Company

EX-99.1 Exhibit 99.1 For Immediate Release InSite Vision Receives Second Unsolicited Acquisition Proposal for $0.35 per Share from a Global Pharmaceutical Company ALAMEDA, Calif. ? September 3, 2015 ? InSite Vision Inc. (OTCBB: INSV) today announced that the Company has received a second unsolicited proposal from a global pharmaceutical company to acquire all outstanding shares of InSite Vision co

August 28, 2015 EX-2.1

SECOND AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, QLT INC. and ISOTOPE ACQUISITION CORP. Dated as of June 8, 2015, as amended and restated August 26, 2015 TABLE OF CONTENTS

QuickLinks - Click here to rapidly navigate through this document Exhibit 2.1 EXECUTION COPY SECOND AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, QLT INC. and ISOTOPE ACQUISITION CORP. Dated as of June 8, 2015, as amended and restated August 26, 2015 TABLE OF CONTENTS Page ARTICLE I—THE MERGER 2 Section 1.1 Merger Sub Subscription 2 Section 1.2 The Merg

August 28, 2015 425

Qlt 8-K (Prospectus)

QuickLinks - Click here to rapidly navigate through this document UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 26, 2015 QLT Inc.

August 27, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 5 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock

424(b)(3) Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-205644 PROSPECTUS SUPPLEMENT NO. 5 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock This Prospectus Supplement No. 5 supplements our Prospectus, dated July 16, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 3,464

August 27, 2015 EX-99.1

QLT AND INSITE VISION AGREE ON AMENDED AND RESTATED MERGER AGREEMENT

Exhibit 99.1 News release QLT AND INSITE VISION AGREE ON AMENDED AND RESTATED MERGER AGREEMENT For Immediate Release August 27, 2015 VANCOUVER, CANADA ? QLT Inc. (NASDAQ:QLTI) (TSX:QLT) (?QLT?) today announced that it has entered into an Amended and Restated Merger Agreement with InSite Vision Incorporated (OTCBB: INSV) (?InSite Vision?), pursuant to which QLT will acquire InSite Vision in a share

August 27, 2015 EX-99.1

InSite Vision and QLT Amend Merger Agreement InSite Board Determines Previously Announced Unsolicited Binding Offer from a Multi-National Pharmaceutical Company No Longer Constitutes a “Company Superior Proposal”

EX-99.1 Exhibit 99.1 InSite Vision and QLT Amend Merger Agreement InSite Board Determines Previously Announced Unsolicited Binding Offer from a Multi-National Pharmaceutical Company No Longer Constitutes a ?Company Superior Proposal? ALAMEDA, Calif. ? August 27, 2015 ? InSite Vision Inc. (OTCBB: INSV) today announced that InSite and QLT Inc. (NASDAQ: QLTI) (TSX: QLT) entered into a revised merger

August 27, 2015 425

Qlt 8-K (Prospectus)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 27, 2015 QLT Inc. (Exact Name of Registrant as specified in its charter) British Columbia, Canada 000-17082 N/A (State or Other Jurisdiction of Incorporation) (Commission File

August 27, 2015 8-K

INSV 8-K (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 26, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Com

August 27, 2015 EX-99.1

InSite Vision and QLT Amend Merger Agreement InSite Board Determines Previously Announced Unsolicited Binding Offer from a Multi-National Pharmaceutical Company No Longer Constitutes a “Company Superior Proposal”

EX-99.1 Exhibit 99.1 InSite Vision and QLT Amend Merger Agreement InSite Board Determines Previously Announced Unsolicited Binding Offer from a Multi-National Pharmaceutical Company No Longer Constitutes a ?Company Superior Proposal? ALAMEDA, Calif. ? August 27, 2015 ? InSite Vision Inc. (OTCBB: INSV) today announced that InSite and QLT Inc. (NASDAQ: QLTI) (TSX: QLT) entered into a revised merger

August 27, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 10 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424(b)(3) Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS SUPPLEMENT NO. 10 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This Prospectus Supplement No. 10 supplements our Prospectus, dated March 17, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 5

August 27, 2015 EX-2.1

SECOND AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, QLT INC. ISOTOPE ACQUISITION CORP. Dated as of June 8, 2015, as amended and restated August 26, 2015 TABLE OF CONTENTS Page ARTICLE I - THE MERGER 2 Sec

EX-2.1 Exhibit 2.1 EXECUTION COPY SECOND AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, QLT INC. and ISOTOPE ACQUISITION CORP. Dated as of June 8, 2015, as amended and restated August 26, 2015 TABLE OF CONTENTS Page ARTICLE I - THE MERGER 2 Section 1.1 Merger Sub Subscription 2 Section 1.2 The Merger 3 Section 1.3 Closing 3 Section 1.4 Effective Time 3 S

August 27, 2015 425

INSV 8-K (Prospectus)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 26, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Com

August 27, 2015 EX-2.1

SECOND AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, QLT INC. ISOTOPE ACQUISITION CORP. Dated as of June 8, 2015, as amended and restated August 26, 2015 TABLE OF CONTENTS Page ARTICLE I - THE MERGER 2 Sec

EX-2.1 Exhibit 2.1 EXECUTION COPY SECOND AMENDED AND RESTATED AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, QLT INC. and ISOTOPE ACQUISITION CORP. Dated as of June 8, 2015, as amended and restated August 26, 2015 TABLE OF CONTENTS Page ARTICLE I - THE MERGER 2 Section 1.1 Merger Sub Subscription 2 Section 1.2 The Merger 3 Section 1.3 Closing 3 Section 1.4 Effective Time 3 S

August 21, 2015 EX-99.1

InSite Vision Determines that an Unsolicited Offer from a Multi-National Pharmaceutical Company to Acquire InSite for $0.25 in Cash Constitutes a “Company Superior Proposal”

EX-99.1 Exhibit 99.1 InSite Vision Determines that an Unsolicited Offer from a Multi-National Pharmaceutical Company to Acquire InSite for $0.25 in Cash Constitutes a ?Company Superior Proposal? ALAMEDA, Calif. ? August 21, 2015 ? InSite Vision Inc. (OTCBB: INSV) today announced that InSite?s Board of Directors determined that the previously announced unsolicited offer from a multi-national pharma

August 21, 2015 EX-99.1

InSite Vision Determines that an Unsolicited Offer from a Multi-National Pharmaceutical Company to Acquire InSite for $0.25 in Cash Constitutes a ?Company Superior Proposal?

EX-99.1 Exhibit 99.1 InSite Vision Determines that an Unsolicited Offer from a Multi-National Pharmaceutical Company to Acquire InSite for $0.25 in Cash Constitutes a ?Company Superior Proposal? ALAMEDA, Calif. ? August 21, 2015 ? InSite Vision Inc. (OTCBB: INSV) today announced that InSite?s Board of Directors determined that the previously announced unsolicited offer from a multi-national pharma

August 21, 2015 EX-99.1

QLT PROVIDES UPDATE ON ITS PROPOSED ACQUISITION OF INSITE VISION INCORPORATED

Exhibit 99.1 News release QLT PROVIDES UPDATE ON ITS PROPOSED ACQUISITION OF INSITE VISION INCORPORATED For Immediate Release August 21, 2015 VANCOUVER, CANADA ? QLT Inc. (NASDAQ: QLTI; TSX: QLT) (?QLT? or the ?Company?) announces that it has been advised by InSite Vision Incorporated (?InSite?) that the board of directors of InSite has determined in good faith after consultation with its independ

August 21, 2015 425

INSV 8-K (Prospectus)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 21, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Com

August 21, 2015 425

Qlt 8-K (Prospectus)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 21, 2015 QLT Inc. (Exact Name of Registrant as specified in its charter) British Columbia, Canada 000-17082 N/A (State or Other Jurisdiction of Incorporation) (Commission File

August 21, 2015 8-K

INSV 8-K (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 21, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Com

August 21, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 4 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock

424(B)(3) Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-205644 PROSPECTUS SUPPLEMENT NO. 4 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock This Prospectus Supplement No. 4 supplements our Prospectus, dated July 16, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 3,464

August 21, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 9 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424(b)(3) Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS SUPPLEMENT NO. 9 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This Prospectus Supplement No. 9 supplements our Prospectus, dated March 17, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 5,0

August 19, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 3 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock

424(b)(3) Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-205644 PROSPECTUS SUPPLEMENT NO. 3 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock This Prospectus Supplement No. 3 supplements our Prospectus, dated July 16, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 3,464

August 19, 2015 425

INSV FORM 425 (Prospectus)

Form 425 Filed by InSite Vision Incorporated Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Exchange Act of 1934 Subject Company: InSite Vision Incorporated Commission File No.

August 19, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 8 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424(b)(3) Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS SUPPLEMENT NO. 8 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This Prospectus Supplement No. 8 supplements our Prospectus, dated March 17, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 5,0

August 13, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 2 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock

424B3 Table of Contents Filed Pursuant to Rule 424(b)(3) Registration Statement No.

August 13, 2015 10-Q

INSV 10-Q (Quarterly Report)

10-Q Table of Contents SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2015 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 0-22332 INSI

August 13, 2015 EX-24

POWER OF ATTORNEY July 29, 2015

EX-24 EXHIBIT 24 POWER OF ATTORNEY July 29, 2015 Know all by these presents, that the undersigned hereby constitutes and appoints Christopher Shackelton the undersigned’s true and lawful attorney-in-fact to: 1.

August 13, 2015 SC 13G/A

INSV / Insite Vision Inc / Coliseum Capital Management, LLC - SC 13G/A Passive Investment

SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 6)* InSite Vision Incorporated (Name of Issuer) Common Stock, $0.01 par value per share (Title of Class of Securities) 457660108 (CUSIP Number) August 10, 2015 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to de

August 13, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 7 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424B3 Table of Contents Filed Pursuant to Rule 424(b)(3) Registration Statement No.

August 11, 2015 EX-99.1

InSite Reports Second Quarter 2015 Financial Results

EX-99.1 Exhibit 99.1 InSite Reports Second Quarter 2015 Financial Results Alameda, Calif., August 11, 2015 ? InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter ended June 30, 2015. Revenues for the quarter ended June 30, 2015 were $0.4 million compared to $6.3 million for the same period in 2014; revenues in 2014 included a $6.0 million payment from Akorn, In

August 11, 2015 DEFA14A

INSV FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation)

August 11, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 6 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424B3 Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS SUPPLEMENT NO. 6 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This Prospectus Supplement No. 6 supplements our Prospectus, dated March 17, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 5,078,0

August 11, 2015 8-K

INSV FORM 8-K (Current Report/Significant Event)

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation)

August 11, 2015 8-K

INSV FORM 8-K (Current Report/Significant Event)

Form 8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) August 11, 2015 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

August 11, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 1 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock

424B3 Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-205644 PROSPECTUS SUPPLEMENT NO. 1 (TO PROSPECTUS DATED JULY 16, 2015) INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock This Prospectus Supplement No. 1 supplements our Prospectus, dated July 16, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 3,464,456

August 10, 2015 DEFA14A

INSV FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation)

August 10, 2015 EX-99.1

InSite Vision Receives Unsolicited Proposal from a Multi-National Pharmaceutical Company

EX-99.1 Exhibit 99.1 InSite Vision Receives Unsolicited Proposal from a Multi-National Pharmaceutical Company ALAMEDA, Calif. ? August 10, 2015 ? InSite Vision Inc. (OTCBB: INSV) today announced that InSite Vision has received an unsolicited proposal from a multi-national pharmaceutical company pharmaceutical company to acquire all outstanding shares of InSite Vision common stock at a price of $0.

August 10, 2015 425

Qlt 8-K (Prospectus)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): August 10, 2015 QLT Inc. (Exact Name of Registrant as specified in its charter) British Columbia, Canada 000-17082 N/A (State or Other Jurisdiction of Incorporation) (Commission File

August 10, 2015 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Commiss

August 10, 2015 EX-99.1

QLT PROVIDES UPDATE ON MERGER WITH INSITE VISION INCORPORATED

Exhibit 99.1 News release QLT PROVIDES UPDATE ON MERGER WITH INSITE VISION INCORPORATED For Immediate Release August 10, 2015 VANCOUVER, CANADA ? QLT Inc. (NASDAQ: QLTI; TSX: QLT) (?QLT? or the ?Company?) announces that it has been advised by InSite Vision Incorporated (?InSite Vision?) that InSite Vision has received an unsolicited offer from a multi-national pharmaceutical company to acquire all

August 10, 2015 EX-99.1

InSite Vision Receives Unsolicited Proposal from a Multi-National Pharmaceutical Company

EX-99.1 Exhibit 99.1 InSite Vision Receives Unsolicited Proposal from a Multi-National Pharmaceutical Company ALAMEDA, Calif. ? August 10, 2015 ? InSite Vision Inc. (OTCBB: INSV) today announced that InSite Vision has received an unsolicited proposal from a multi-national pharmaceutical company pharmaceutical company to acquire all outstanding shares of InSite Vision common stock at a price of $0.

July 16, 2015 424B3

INSITE VISION INCORPORATED 3,464,456 Shares of Common Stock

424B3 Table of Contents Filed Pursuant to Rule 424(b)(3) Registration Statement No.

July 15, 2015 CORRESP

INSV ESP

CORRESP July 15, 2015 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, DC 20549 Attention: Jeffrey P.

July 13, 2015 S-1

INSV FORM S-1

Table of Contents As filed with the Securities and Exchange Commission on July 13, 2015 Registration No.

June 12, 2015 EX-2.5

QLT Inc. 887 Great Northern Way, Suite 250 Vancouver, B.C., Canada, V5T 4T5

Exhibit 2.5 EXECUTION COPY QLT Inc. 887 Great Northern Way, Suite 250 Vancouver, B.C., Canada, V5T 4T5 June 8, 2015 Private & Confidential Broadfin Healthcare Master Fund Ltd 300 Park Avenue, 25th Floor New York, NY 10005 JW Partners, LP and JW Opportunities Fund, LLC c/o JW GP, LLC 515 Madison Ave, 14B New York, NY 10022 EcoR1 Capital Fund Qualified, L.P. and EcoR1 Capital Fund, L.P. c/o EcoR1 Ca

June 12, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 5 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

Prospectus Supplement No. 5 Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS SUPPLEMENT NO. 5 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This Prospectus Supplement No. 5 supplements our Prospectus, dated March 17, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to a

June 12, 2015 425

Qlt 8-K (Prospectus)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): June 8, 2015 QLT Inc. (Exact Name of Registrant as specified in its charter) British Columbia, Canada 000-17082 N/A (State or Other Jurisdiction of Incorporation) (Commission File Num

June 12, 2015 EX-2.4

SHARE PURCHASE AND REGISTRATION RIGHTS AGREEMENT

Exhibit 2.4 EXECUTION COPY SHARE PURCHASE AND REGISTRATION RIGHTS AGREEMENT This SHARE PURCHASE AND REGISTRATION RIGHTS AGREEMENT (this ?Agreement?) is entered into and effective as of June 8, 2015, between QLT Inc., a corporation existing under the laws of the Province of British Columbia, Canada (the ?Company?), and the several investors set forth on Schedule I hereto (each an ?Investor? and col

June 12, 2015 EX-2.3

W I T N E S S E T H:

Exhibit 2.3 EXECUTION COPY This SHARE PURCHASE AGREEMENT, dated June 8, 2015, is by and between QLT Inc., a corporation incorporated under the laws of British Columbia (?Quest?) and Broadfin Healthcare Master Fund, Ltd, JW Partners, LP, JW Opportunities Fund, LLC, EcoR1 Capital Fund Qualified, L.P. and EcoR1 Capital Fund, L.P. (each, a ?Backstop Purchaser? and collectively, the ?Backstop Purchaser

June 11, 2015 EX-10.1

INTERCREDITOR AGREEMENT

EX-10.1 Exhibit 10.1 EXECUTION VERSION INTERCREDITOR AGREEMENT Intercreditor Agreement (this ?Agreement?), dated as of June 9, 2015, among QLT INC., as secured party (in such capacity, with its successors and assigns, and as more specifically defined below, the ?First Priority Creditor?) for the First Priority Secured Parties (as defined below), U.S. BANK NATIONAL ASSOCIATION, as collateral agent

June 11, 2015 8-K

INSV 8-K (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 9, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Commis

June 11, 2015 EX-10.2

FORM OF AMENDMENT, WAIVER AND CONSENT

EX-10.2 3 d941531dex102.htm EX-10.2 Exhibit 10.2 FORM OF AMENDMENT, WAIVER AND CONSENT TO: INSITE VISION INCORPORATED (the “Corporation”) RE: 12% SECURED SENIOR NOTES OF THE CORPORATION WHEREAS: A. The undersigned (the “Holder”) is the holder of a 12% senior secured notes in the aggregate principal amount of US$[●] (the “Holder Notes”, and together with all other notes issued pursuant to the Purch

June 11, 2015 EX-99.1

InSite Vision Announces Completion of the New Drug Application Submission to the U.S. FDA for BromSite™ First Anti-Inflammatory Drug to be Indicated for Prevention of Pain in Cataract Surgery

EX-99.1 Exhibit 99.1 For Immediate Release InSite Vision Announces Completion of the New Drug Application Submission to the U.S. FDA for BromSite? First Anti-Inflammatory Drug to be Indicated for Prevention of Pain in Cataract Surgery ALAMEDA, California ? June 11, 2015 ? InSite Vision Incorporated (OTCBB: INSV) today announced that it has completed the submission to the U.S. Food and Drug Adminis

June 11, 2015 EX-10.2

FORM OF AMENDMENT, WAIVER AND CONSENT

EX-10.2 Exhibit 10.2 FORM OF AMENDMENT, WAIVER AND CONSENT TO: INSITE VISION INCORPORATED (the ?Corporation?) RE: 12% SECURED SENIOR NOTES OF THE CORPORATION WHEREAS: A. The undersigned (the ?Holder?) is the holder of a 12% senior secured notes in the aggregate principal amount of US$[?] (the ?Holder Notes?, and together with all other notes issued pursuant to the Purchase Agreement (as defined be

June 11, 2015 EX-10.1

INTERCREDITOR AGREEMENT

EX-10.1 Exhibit 10.1 EXECUTION VERSION INTERCREDITOR AGREEMENT Intercreditor Agreement (this ?Agreement?), dated as of June 9, 2015, among QLT INC., as secured party (in such capacity, with its successors and assigns, and as more specifically defined below, the ?First Priority Creditor?) for the First Priority Secured Parties (as defined below), U.S. BANK NATIONAL ASSOCIATION, as collateral agent

June 11, 2015 EX-99.1

InSite Vision Announces Completion of the New Drug Application Submission to the U.S. FDA for BromSite™ First Anti-Inflammatory Drug to be Indicated for Prevention of Pain in Cataract Surgery

EX-99.1 Exhibit 99.1 For Immediate Release InSite Vision Announces Completion of the New Drug Application Submission to the U.S. FDA for BromSite? First Anti-Inflammatory Drug to be Indicated for Prevention of Pain in Cataract Surgery ALAMEDA, California ? June 11, 2015 ? InSite Vision Incorporated (OTCBB: INSV) today announced that it has completed the submission to the U.S. Food and Drug Adminis

June 11, 2015 DEFA14A

INSV 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 9, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Commis

June 10, 2015 8-K

INSV 8-K (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Commis

June 10, 2015 EX-99.1

InSite Vision Incorporated / QLT Inc.

InSite Vision Incorporated / QLT Inc. Transaction InSite Vision Incorporated / QLT Inc. Transaction June 8, 2015 Exhibit 99.1 2 Cautionary Statement Regarding Forward Looking Statements Cautionary Statement Regarding Forward Looking Statements Statements in this document that are not strictly historical, including statements regarding the proposed acquisition, the expected timetable for completing

June 10, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 4 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424B3 Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS SUPPLEMENT NO. 4 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This Prospectus Supplement No. 4 supplements our Prospectus, dated March 17, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 5,078,0

June 10, 2015 EX-99.2

InSite Vision Incorporated Corporate Conference Call June 8, 2015 Corporate Speakers ? Louis Drapeau InSite Vision Incorporated CFO, VP - Finance ? Timothy Ruane InSite Vision Incorporated CEO Conference Participants ? Rick Elkin ? Noah Alpern ? Loui

EX-99.2 Exhibit 99.2 InSite Vision Incorporated Corporate Conference Call June 8, 2015 Corporate Speakers ? Louis Drapeau InSite Vision Incorporated CFO, VP - Finance ? Timothy Ruane InSite Vision Incorporated CEO Conference Participants ? Rick Elkin ? Noah Alpern ? Louis Alpern ? Michael Rosetta PRESENTATION Operator^ Good day ladies and gentlemen, and welcome to the InSite Vision to Merge with C

June 10, 2015 DEFA14A

INSV 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Commis

June 10, 2015 EX-99.2

InSite Vision Incorporated Corporate Conference Call June 8, 2015 Corporate Speakers ? Louis Drapeau InSite Vision Incorporated CFO, VP - Finance ? Timothy Ruane InSite Vision Incorporated CEO Conference Participants ? Rick Elkin ? Noah Alpern ? Loui

EX-99.2 Exhibit 99.2 InSite Vision Incorporated Corporate Conference Call June 8, 2015 Corporate Speakers ? Louis Drapeau InSite Vision Incorporated CFO, VP - Finance ? Timothy Ruane InSite Vision Incorporated CEO Conference Participants ? Rick Elkin ? Noah Alpern ? Louis Alpern ? Michael Rosetta PRESENTATION Operator^ Good day ladies and gentlemen, and welcome to the InSite Vision to Merge with C

June 10, 2015 EX-99.1

InSite Vision Incorporated / QLT Inc.

InSite Vision Incorporated / QLT Inc. Transaction InSite Vision Incorporated / QLT Inc. Transaction June 8, 2015 Exhibit 99.1 2 Cautionary Statement Regarding Forward Looking Statements Cautionary Statement Regarding Forward Looking Statements Statements in this document that are not strictly historical, including statements regarding the proposed acquisition, the expected timetable for completing

June 8, 2015 EX-99.1

QLT ANNOUNCES MULTIPLE TRANSACTIONS DESIGNED TO TRANSFORM THE COMPANY AND CREATE SIGNIFICANT NEAR- AND LONG-TERM VALUE FOR SHAREHOLDERS QLT to Acquire InSite Vision to Create a Diversified, Pure-Play, Late-Stage Ophthalmic Pharmaceutical Company Comb

Exhibit 99.1 N e w s r e l e a s e QLT ANNOUNCES MULTIPLE TRANSACTIONS DESIGNED TO TRANSFORM THE COMPANY AND CREATE SIGNIFICANT NEAR- AND LONG-TERM VALUE FOR SHAREHOLDERS QLT to Acquire InSite Vision to Create a Diversified, Pure-Play, Late-Stage Ophthalmic Pharmaceutical Company Combined Company Will Be Well-Capitalized with a Cash Balance of Approximately $70 Million, Including Newly Invested Ca

June 8, 2015 EX-10.1

INSITE VISION INCORPORATED SECURED NOTE USD$9,853,333 June 8, 2015

EX-10.1 Exhibit 10.1 INSITE VISION INCORPORATED SECURED NOTE USD$9,853,333 June 8, 2015 FOR VALUE RECEIVED, InSite Vision Incorporated, a Delaware corporation (the ?Maker?), promises to pay to the order of QLT Inc. (the ?Holder?), at 887 Great Northern Way, Suite 250 Vancouver, BC V5T 4T5, Canada, the principal sum of $9,853,333 (or such lesser outstanding amount advanced to the Maker by the Holde

June 8, 2015 425

Qlt 8-K (Prospectus)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of Earliest Event Reported): June 8, 2015 QLT Inc. (Exact Name of Registrant as specified in its charter) British Columbia, Canada 000-17082 N/A (State or Other Jurisdiction of Incorporation) (Commission File Num

June 8, 2015 EX-10.2

SECURITY AGREEMENT

EX-10.2 Exhibit 10.2 SECURITY AGREEMENT This Security Agreement dated as of June 8, 2015 (this ?Agreement?), is made by InSite Vision Incorporated, a Delaware corporation (the ?Company?), in favor of QLT Inc. (the ?Secured Party?). PRELIMINARY STATEMENTS: A. Pursuant to the Secured Note dated as of June 8, 2015 (as amended, restated, supplemented or otherwise modified from time to time, the ?Note?

June 8, 2015 EX-10.1

INSITE VISION INCORPORATED SECURED NOTE USD$9,853,333 June 8, 2015

EX-10.1 Exhibit 10.1 INSITE VISION INCORPORATED SECURED NOTE USD$9,853,333 June 8, 2015 FOR VALUE RECEIVED, InSite Vision Incorporated, a Delaware corporation (the ?Maker?), promises to pay to the order of QLT Inc. (the ?Holder?), at 887 Great Northern Way, Suite 250 Vancouver, BC V5T 4T5, Canada, the principal sum of $9,853,333 (or such lesser outstanding amount advanced to the Maker by the Holde

June 8, 2015 EX-2.1

AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, QLT INC. ISOTOPE ACQUISITION CORP. Dated as of June 8, 2015 TABLE OF CONTENTS Page ARTICLE I - THE MERGER 2 Section 1.1 Merger Sub Subscription 2 Section 1.2 The Merger 2 Section 1

EX-2.1 Exhibit 2.1 EXECUTION COPY AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, QLT INC. and ISOTOPE ACQUISITION CORP. Dated as of June 8, 2015 TABLE OF CONTENTS Page ARTICLE I - THE MERGER 2 Section 1.1 Merger Sub Subscription 2 Section 1.2 The Merger 2 Section 1.3 Closing 2 Section 1.4 Effective Time 3 Section 1.5 Effects of the Merger 3 Section 1.6 Organizational Documen

June 8, 2015 EX-99.1

InSite Vision to Merge with Canadian Biotechnology Company QLT

EX-99.1 Exhibit 99.1 For Immediate Release InSite Vision to Merge with Canadian Biotechnology Company QLT ? New Company will be a Well-Funded Pure Play Specialty Ophthalmic Company ? BromSite? NDA Submission to FDA to be Promptly Filed this Week ? Alameda (InSite) and Vancouver (QLT) Operations to Continue to Progress Phase 3 Retinoid Program ? QLT?s Canadian-Domiciled Structure Creates Favorable

June 8, 2015 EX-99.1

InSite Vision to Merge with Canadian Biotechnology Company QLT

EX-99.1 Exhibit 99.1 For Immediate Release InSite Vision to Merge with Canadian Biotechnology Company QLT ? New Company will be a Well-Funded Pure Play Specialty Ophthalmic Company ? BromSite? NDA Submission to FDA to be Promptly Filed this Week ? Alameda (InSite) and Vancouver (QLT) Operations to Continue to Progress Phase 3 Retinoid Program ? QLT?s Canadian-Domiciled Structure Creates Favorable

June 8, 2015 EX-10.2

SECURITY AGREEMENT

Exhibit 10.2 SECURITY AGREEMENT This Security Agreement dated as of June 8, 2015 (this “Agreement”), is made by InSite Vision Incorporated, a Delaware corporation (the “Company”), in favor of QLT Inc. (the “Secured Party”). PRELIMINARY STATEMENTS: A. Pursuant to the Secured Note dated as of June 8, 2015 (as amended, restated, supplemented or otherwise modified from time to time, the “Note”), betwe

June 8, 2015 DEFA14A

INSV 8-K

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Commis

June 8, 2015 425

Qlt 425 (Prospectus)

Filed by QLT Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Securities Act of 1934 Subject Company: INSITE VISION INCORPORATED Commission File No.: 0-22332 Date: June 8, 2015 Transformational Transactions Designed to Unlock Value at QLT June 8, 2015 2 Forward-Looking Statement Important Information For Investors And Shareholders This c

June 8, 2015 425

Qlt 425 (Prospectus)

Filed by QLT Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Securities Act of 1934 Subject Company: INSITE VISION INCORPORATED Commission File No.: 0-22332 Date: June 8, 2015 New QLT A Diversified, Pure-Play, Late-Stage Ophthalmic Pharmaceutical Company June 8, 2015 2 Forward-Looking Statement Important Information For Investors And Sh

June 8, 2015 EX-10.3

INTELLECTUAL PROPERTY SECURITY AGREEMENT

EX-10.3 Exhibit 10.3 INTELLECTUAL PROPERTY SECURITY AGREEMENT This Intellectual Property Security Agreement is entered into as of June 8, 2015, is between QLT Inc. (the ?Secured Party?) and InSite Vision Incorporated, a Delaware corporation (the ?Grantor?). RECITALS A. Pursuant to the Secured Note dated as of June 8, 2015 (as amended, restated, supplemented or otherwise modified from time to time,

June 8, 2015 EX-2.1

AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, QLT INC. ISOTOPE ACQUISITION CORP. Dated as of June 8, 2015 TABLE OF CONTENTS Page ARTICLE I - THE MERGER 2 Section 1.1 Merger Sub Subscription 2 Section 1.2 The Merger 2 Section 1

EX-2.1 Exhibit 2.1 EXECUTION COPY AGREEMENT AND PLAN OF MERGER by and among INSITE VISION INCORPORATED, QLT INC. and ISOTOPE ACQUISITION CORP. Dated as of June 8, 2015 TABLE OF CONTENTS Page ARTICLE I - THE MERGER 2 Section 1.1 Merger Sub Subscription 2 Section 1.2 The Merger 2 Section 1.3 Closing 2 Section 1.4 Effective Time 3 Section 1.5 Effects of the Merger 3 Section 1.6 Organizational Documen

June 8, 2015 EX-10.3

INTELLECTUAL PROPERTY SECURITY AGREEMENT

EX-10.3 Exhibit 10.3 INTELLECTUAL PROPERTY SECURITY AGREEMENT This Intellectual Property Security Agreement is entered into as of June 8, 2015, is between QLT Inc. (the ?Secured Party?) and InSite Vision Incorporated, a Delaware corporation (the ?Grantor?). RECITALS A. Pursuant to the Secured Note dated as of June 8, 2015 (as amended, restated, supplemented or otherwise modified from time to time,

June 8, 2015 8-K

INSV 8-K (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2015 INSITE VISION INCORPORATED (Exact Name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Commis

June 8, 2015 425

Qlt 425 (Prospectus)

Filed by QLT Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 under the Securities Act of 1934 Subject Company: INSITE VISION INCORPORATED Commission File No.: 0-22332 Date: June 8, 2015 N e w s r e l e a s e QLT ANNOUNCES MULTIPLE TRANSACTIONS DESIGNED TO TRANSFORM THE COMPANY AND CREATE SIGNIFICANT NEAR- AND LONG-TERM VALUE FOR SHAREHOLDERS QLT

May 12, 2015 8-K

Results of Operations and Financial Condition

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 12, 2015 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

May 12, 2015 EX-99.1

InSite Vision Reports First Quarter 2015 Financial Results

EX-99.1 2 d925205dex991.htm EX-99.1 Exhibit 99.1 InSite Vision Reports First Quarter 2015 Financial Results Alameda, Calif., May 12, 2015 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter ended March 31, 2015. Revenues for the quarter ended March 31, 2015 were $3.4 million compared to $1.2 million for the same period in 2014; increase in revenues was due t

May 12, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 3 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424B3 Table of Contents Filed Pursuant to Rule 424(b)(3) Registration Statement No.

April 17, 2015 8-K

INSV 8-K (Current Report/Significant Event)

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 17, 2015 INSITE VISION INCORPORATED (Exact name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Comm

April 17, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 2

424B3 Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS SUPPLEMENT NO. 2 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This Prospectus Supplement No. 2 supplements our Prospectus, dated March 17, 2015, and our Prospectus Supplement No. 1, dated April 2, 2015, and relates to the resale by the selling stockholders ide

April 2, 2015 EX-3.1

CERTIFICATE OF AMENDMENT TO THE RESTATED CERTIFICATE OF INCORPORATION OF INSITE VISION INCORPORATED

EX-3.1 Exhibit 3.1 CERTIFICATE OF AMENDMENT TO THE RESTATED CERTIFICATE OF INCORPORATION OF INSITE VISION INCORPORATED Pursuant to Section 242 of the General Corporation Law of the State of Delaware, InSite Vision Incorporated, a corporation organized and existing under the laws of the State of Delaware (the ?Corporation?), does here by certify as follows: The name of the Corporation is InSite Vis

April 2, 2015 8-K

INSV FORM 8-K (Current Report/Significant Event)

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): March 31, 2015 INSITE VISION INCORPORATED (Exact name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction (Commission (IRS E

April 2, 2015 424B3

PROSPECTUS SUPPLEMENT NO. 1 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424B3 Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS SUPPLEMENT NO. 1 (TO PROSPECTUS DATED MARCH 17, 2015) INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This Prospectus Supplement No. 1 supplements our Prospectus, dated March 17, 2015, and relates to the resale by the selling stockholders identified in the Prospectus of up to an aggregate of 5,078,0

March 17, 2015 424B3

INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(3) Registration Statement No. 333-201052 PROSPECTUS INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock This prospectus covers the resale by the selling stockholders identified in this prospectus of up to an aggregate of 5,078,070 shares of our common stock issuable upon the exercise of outstanding warrants. The warrants were issued and sold

February 20, 2015 POS AM

INSV / Insite Vision Inc POS AM - - POST-EFFECTIVE AMENDMENT NO. 1

Post-Effective Amendment No. 1 Table of Contents As filed with the Securities and Exchange Commission on February 20, 2015 Registration No. 333-201052 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 AMENDMENT NO. 1 TO FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 INSITE VISION INCORPORATED (Exact name of registrant as specified in its charter) Delaware 28

February 20, 2015 EX-10.37

CONFIDENTIAL TREATMENT REQUESTED BY INSITE VISION INCORPORATED—CONFIDENTIAL PORTIONS OF THIS DOCUMENT HAVE BEEN REDACTED AND HAVE BEEN SEPARATELY FILED WITH THE COMMISSION

EX-10.37 Exhibit 10.37 CONFIDENTIAL TREATMENT REQUESTED BY INSITE VISION INCORPORATED—CONFIDENTIAL PORTIONS OF THIS DOCUMENT HAVE BEEN REDACTED AND HAVE BEEN SEPARATELY FILED WITH THE COMMISSION Exclusive Licence and Development Agreement Dated 29 January 2015 Insite Vision Incorporated (1) Nicox S.A. (2) EXECUTION VERSION TABLE OF CONTENTS 1 Definitions and interpretation 2 2 Appointment, license

February 19, 2015 DEF 14A

INSV / Insite Vision Inc DEF 14A - - DEF 14A

DEF 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨

February 17, 2015 EX-99.1

InSite Vision Reports Fourth Quarter and Year-End 2014 Financial Results

EX-99.1 2 d875992dex991.htm EX-99.1 Exhibit 99.1 InSite Vision Reports Fourth Quarter and Year-End 2014 Financial Results Alameda, Calif., February 17, 2015 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter and year ended December 31, 2014. The Company reported net income for the years ended 2014 and 2013 of $26.8 million, or $0.20 per share, in 2014 and $

February 17, 2015 EX-99.A

Joint Filing Agreement Pursuant to Rule 13d-1

EX-99.A 2 d874267dex99a.htm EX-99.A Exhibit A Joint Filing Agreement Pursuant to Rule 13d-1 This agreement is made pursuant to Rule 13d-l(k)(1) under the Securities and Exchange Act of 1934, as amended (the “Act”) by and among the parties listed below, each referenced to herein as a “Joint Filer.” The Joint Filers agree that a statement of beneficial ownership as required by Sections 13(g) or 13(d

February 17, 2015 SC 13G/A

INSV / Insite Vision Inc / Coliseum Capital Management, LLC - SC 13G/A Passive Investment

SC 13G/A 1 d874267dsc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 5)* InSite Vision Incorporated (Name of Issuer) Common Stock, $0.01 par value per share (Title of Class of Securities) 457660108 (CUSIP Number) December 31, 2014 (Date of Event Which Requires Filing of this Statement)

February 17, 2015 SC 13G/A

INSV / Insite Vision Inc / Jacobson Eli D - SCHEDULE 13G/A Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 12)* INSITE VISION INCORPORATED (Name of Issuer) COMMON STOCK, PAR VALUE $0.01 PER SHARE (Title of Class of Securities) 457660108 (CUSIP Number) December 31, 2014 (Date of Event Which Requires Filing of this Statement) Check the appropriate box

February 17, 2015 8-K

Results of Operations and Financial Condition

Form 8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) February 17, 2015 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

February 9, 2015 PRE 14A

INSV / Insite Vision Inc PRE 14A - - PRELIMINARY PROXY STATEMENT

Preliminary Proxy Statement UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

February 4, 2015 8-K

Entry into a Material Definitive Agreement

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): January 29, 2015 INSITE VISION INCORPORATED (Exact name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation

January 5, 2015 424B3

INSITE VISION INCORPORATED 5,078,070 Shares of Common Stock

424B3 Table of Contents Filed Pursuant to Rule 424(b)(3) Registration Statement No.

December 19, 2014 EX-99.1

InSite Vision Announces Date for Annual Stockholder Meeting

EX-99.1 Exhibit 99.1 InSite Vision Announces Date for Annual Stockholder Meeting Alameda, Calif., December 19, 2014 – InSite Vision Incorporated (OTCBB: INSV), a company developing ophthalmic products for unmet eye care needs, today announced that the company’s 2015 Annual Meeting of Stockholders will be held at 10:00 a.m. Pacific Time on Monday, March 31, 2015, for stockholders of record on Febru

December 19, 2014 8-K

Financial Statements and Exhibits, Other Events

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 19, 2014 INSITE VISION INCORPORATED (Exact name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (C

December 18, 2014 S-1

INSV / Insite Vision Inc S-1 - Registration Statement - S-1

S-1 Table of Contents As filed with the Securities and Exchange Commission on December 18, 2014 Registration No.

December 18, 2014 EX-10.33

AMENDMENT NO. 1 SECURITIES PURCHASE AGREEMENT

EX-10.33 Exhibit 10.33 AMENDMENT NO. 1 TO SECURITIES PURCHASE AGREEMENT THIS AMENDMENT NO. 1 TO SECURITIES PURCHASE AGREEMENT (the “Amendment”), is made as of the 21st day of November, 2014, by and between InSite Vision Incorporated, a Delaware corporation (the “Company”) Riverbank Capital Securities, Inc., broker-dealer, as placement agent (the “Placement Agent”), and the undersigned Purchasers c

November 5, 2014 8-K

Results of Operations and Financial Condition

Form 8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) November 5, 2014 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

November 5, 2014 EX-99.1

InSite Vision Reports Third Quarter 2014 Financial Results

EX-99.1 Exhibit 99.1 InSite Vision Reports Third Quarter 2014 Financial Results Alameda, Calif., November 5, 2014 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter ended September 30, 2014. Revenues for the third quarter of 2014 were $0.4 million compared to $5.3 million for the same period in 2013. In the third quarter of 2013, revenues included an additi

October 16, 2014 EX-10.1

SECURITIES PURCHASE AGREEMENT

EX-10.1 Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is made as of October 9, 2014 by and among InSite Vision Incorporated, a Delaware corporation having a place of business at 965 Atlantic Avenue, Alameda, California 94501 (the “Company”), Riverbank Capital Securities, Inc., broker-dealer, as placement agent (the “Placement Agent”), and the unde

October 16, 2014 EX-10.3

INSITE VISION INCORPORATED 12% SENIOR SECURED NOTE $[amount] [ , 201 ]

EX-10.3 Exhibit 10.3 THIS 12% SENIOR SECURED NOTE (THIS “NOTE”) HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR UNDER THE SECURITIES LAWS OF ANY STATE. THIS NOTE IS SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE SOLD, TRANSFERRED OR ASSIGNED (A) IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT FOR THIS NOTE UNDER THE SECURI

October 16, 2014 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): October 9, 2014 INSITE VISION INCORPORATED (Exact name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (Com

October 16, 2014 EX-4.1

INSITE VISION INCORPORATED WARRANT TO PURCHASE COMMON STOCK Warrant No: Original Issue Date: , 20[14/15/16]

EX-4.1 2 d806085dex41.htm EX-4.1 Exhibit 4.1 NEITHER THESE SECURITIES NOR THE SECURITIES ISSUABLE UPON EXERCISE OF THESE SECURITIES HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED (A) IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT FOR THE S

October 16, 2014 EX-10.2

SECURITY AGREEMENT

EX-10.2 Exhibit 10.2 SECURITY AGREEMENT This Security Agreement dated as of October 9, 2014 (this “Agreement”), is made by InSite Vision Incorporated, a Delaware corporation (the “Company”), in favor of the Holders (as defined below) and U.S. Bank National Association, as collateral agent (in such capacity, the “Collateral Agent”) for itself and the Holders (together with the Collateral Agent, the

August 13, 2014 8-K

Results of Operations and Financial Condition

8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) August 13, 2014 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

August 13, 2014 EX-99.1

InSite Vision Reports Second Quarter 2014 Financial Results

EX-99.1 Exhibit 99.1 InSite Vision Reports Second Quarter 2014 Financial Results Alameda, Calif., August 13, 2014 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter ended June 30, 2014. Revenues for the second quarter of 2014 were $6.3 million compared to $19.2 million for the same period in 2013. In the second quarter of 2014, revenues included a $6.0 mill

July 31, 2014 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): July 25, 2014 INSITE VISION INCORPORATED (Exact name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (

July 31, 2014 EX-10.1

INDEMNIFICATION AGREEMENT

EX-10.1 Exhibit 10.1 INDEMNIFICATION AGREEMENT This Indemnification Agreement (“Agreement”) is made as of , 2014 by and between InSite Vision Incorporated, a Delaware corporation (the “Company”), and (“Indemnitee”). This Agreement supersedes and replaces any and all previous Agreements between the Company and Indemnitee covering the subject matter of this Agreement. RECITALS WHEREAS, highly compet

July 22, 2014 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): 07/16/2014 InSite Vision Incorporated (Exact name of registrant as specified in its charter) Commission File Number: 0-22332 Delaware 94-3015807 (State or other jurisdiction of (IRS E

June 13, 2014 EX-10.2

THIRD AMENDMENT TO LICENSE AGREEMENT

EX-10.2 Exhibit 10.2 THIRD AMENDMENT TO LICENSE AGREEMENT This Third Amendment to License Agreement (the “Third Amendment”) is made as of June 10, 2014, 2014 (the “Effective Date”) between Akorn, Inc. (“Akorn”), Inspire Pharmaceuticals (“Inspire”) and InSite Vision Incorporated (“InSite”) (each a “Party,” and together the “Parties”). WHEREAS, Inspire and InSite entered into that certain License Ag

June 13, 2014 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Financial Statements and Exhibits - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): June 10, 2014 INSITE VISION INCORPORATED (Exact name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation) (

June 13, 2014 EX-10.1

NOTE PURCHASE AGREEMENT

EX-10.1 Exhibit 10.1 NOTE PURCHASE AGREEMENT This Note Purchase Agreement, effective as of May 29, 2014 (this “Agreement”), is among each of the purchasers listed on Schedule 1 (each, a “Purchaser” and collectively, the “Purchasers”) and Azithromycin Royalty Sub LLC, a Delaware limited liability company (the “Issuer”). PRELIMINARY STATEMENTS: A. Pursuant to the Indenture dated as of February 21, 2

June 10, 2014 DEFA14A

- DEFA14A

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨

May 28, 2014 DEF 14A

- DEF 14A

DEF 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨

May 16, 2014 PRE 14A

- PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: x Preliminary Proxy Statement ¨ Confide

May 14, 2014 EX-99.1

InSite Vision Reports First Quarter 2014 Financial Results

EX-99.1 Exhibit 99.1 InSite Vision Reports First Quarter 2014 Financial Results Alameda, Calif., May 14, 2014 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter ended March 31, 2014. Revenues for the quarter ended March 31, 2014 were $1.2 million compared to $5.3 million for the same period in 2013. Net loss for the quarter ended March 31, 2014 was $4.7 mil

May 14, 2014 8-K

Results of Operations and Financial Condition - FORM 8-K

Form 8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 14, 2014 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

May 8, 2014 EX-99

InSite Vision Announces Date for Annual Stockholder Meeting

DC14384.pdf - Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing Exhibit 99.1 InSite Vision Announces Date for Annual Stockholder Meeting Alameda, Calif., May 8, 2014 – InSite Vision Incorporated (OTCBB: INSV), a company developing ophthalmic products for unmet eye care needs, today announced that the company’s 2014 Annual Meeting of Stockholders will be held at 10:00

May 8, 2014 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): 05/08/2014 InSite Vision Incorporated (Exact name of registrant as specified in its charter) Commission File Number: 0-22332 Delaware 94-3015807 (State or other jurisdiction of (IRS E

April 1, 2014 S-8

- FORM S-8

Form S-8 As filed with the Securities and Exchange Commission on April 1, 2014 Registration No.

March 31, 2014 10-K

INSV 10-K (Annual Report)

10-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

March 31, 2014 EX-21.1

Subsidiaries of InSite Vision Incorporated Name Place of Incorporation Azithromycin Royalty Sub, LLC Delaware Ophthalmic Solutions, Inc. Delaware InSite Vision, Ltd. United Kingdom

EX-21.1 Exhibit 21.1 Subsidiaries of InSite Vision Incorporated Name Place of Incorporation Azithromycin Royalty Sub, LLC Delaware Ophthalmic Solutions, Inc. Delaware InSite Vision, Ltd. United Kingdom

March 27, 2014 8-K

Results of Operations and Financial Condition

8-K 1 d700907d8k.htm FORM 8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) March 27, 2014 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of

March 27, 2014 EX-99.1

InSite Vision Reports Fourth Quarter and Full-Year 2013 Financial Results

EX-99.1 Exhibit 99.1 InSite Vision Reports Fourth Quarter and Full-Year 2013 Financial Results Alameda, Calif., March 27, 2014 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter and year ended December 31, 2013. Revenues for the year ended December 31, 2013 were $30.8 million compared to $21.6 million for the same period in 2012. Net income for the year end

February 14, 2014 SC 13G/A

INSV / Insite Vision Inc / Coliseum Capital Management, LLC - SC 13G/A Passive Investment

SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934* (Amendment No. 4) InSite Vision Incorporated (Name of Issuer) Common Stock, $0.01 par value per share (Title of Class of Securities) 457660108 (CUSIP Number) December 31, 2013 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to de

February 14, 2014 SC 13G/A

INSV / Insite Vision Inc / Jacobson Eli D - SCHEDULE 13G/A Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 11* INSITE VISION INCORPORATED (Name of Issuer) COMMON STOCK, PAR VALUE $0.01 PER SHARE (Title of Class of Securities) 457660108 (CUSIP Number) December 31, 2013 (Date of Event Which Requires Filing of this Statement) Check the appropriate box

November 12, 2013 8-K

Results of Operations and Financial Condition

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) November 12, 2013 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

November 12, 2013 EX-99.1

InSite Vision Reports Third Quarter 2013 Financial Results

EX-99.1 Exhibit 99.1 InSite Vision Reports Third Quarter 2013 Financial Results Alameda, Calif., November 12, 2013 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter ended September 30, 2013. Revenues for the third quarter of 2013 were $5.3 million compared to $12.1 million for the same period in 2012. Included in the third quarter of 2013 and 2012 were an

September 19, 2013 CORRESP

-

CORRESP CONFIDENTIAL TREATMENT REQUESTED BY INSITE VISION INCORPORATED [InSite Vision Letterhead] September 19, 2013 VIA EDGAR Mr.

August 8, 2013 8-K

Results of Operations and Financial Condition - FORM 8-K

Form 8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) August 8, 2013 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

August 8, 2013 EX-99.1

InSite Vision Reports Second Quarter 2013 Financial Results

EX-99.1 Exhibit 99.1 InSite Vision Reports Second Quarter 2013 Financial Results Alameda, Calif., August 8, 2013 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter ended June 30, 2013. Revenues for the second quarter of 2013 were $19.2 million compared to $1.8 million for the same period in 2012. Included in the second quarter of 2013 were revenues of $15 m

August 2, 2013 8-K

Entry into a Material Definitive Agreement - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 1, 2013 INSITE VISION INCORPORATED (Exact name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporation)

June 26, 2013 8-K

Entry into a Material Definitive Agreement - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): 06/20/2013 InSite Vision Incorporated (Exact name of registrant as specified in its charter) Commission File Number: 0-22332 Delaware 94-3015807 (State or other jurisdiction of (IRS E

May 31, 2013 8-K

Submission of Matters to a Vote of Security Holders - 8K - 2013 SHAREHOLDER MEETING

UNITED STATES UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 29, 2013 INSITE VISION INCORPORATED (Exact Name of Registrant as Specified in Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 (Commission File No.

May 7, 2013 8-K

Results of Operations and Financial Condition - FORM 8-K

Form 8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 7, 2013 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

May 7, 2013 EX-99.1

InSite Vision Reports First Quarter 2013 Financial Results

EX-99.1 Exhibit 99.1 InSite Vision Reports First Quarter 2013 Financial Results Alameda, Calif., May 7, 2013 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter ended March 31, 2013. Revenues for the first quarter of 2013 were $5.3 million compared to $2.3 million for the same period in 2012. Net loss for the first quarter of 2013 was $1.9 million, or $0.01

April 15, 2013 DEF 14A

- DEFINITIVE PROXY STATEMENT

Definitive Proxy Statement UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

April 10, 2013 CORRESP

-

CORRESP [InSite Vision Letterhead] April 10, 2013 VIA EDGAR Mr. Jeffrey P. Riedler, Assistant Director Ms. Amy Reischauer Division of Corporation Finance Securities and Exchange Commission 100 F Street, N.E. Mail Stop 3561 Washington, D.C. 20549 Re: InSite Vision Incorporated (the “Company”) Preliminary Proxy Statement on Schedule 14A Filed April 4, 2013 File Number 000-22332 Dear Mr. Riedler and

April 4, 2013 PRE 14A

- PRELIMINARY PROXY STATEMENT

Preliminary Proxy Statement UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

April 3, 2013 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): 04/02/2013 InSite Vision Incorporated (Exact name of registrant as specified in its charter) Commission File Number: 0-22332 Delaware 94-3015807 (State or other jurisdiction of (IRS E

April 3, 2013 EX-99

InSite Vision Announces Sale of Besivance® Royalty for $15 Million Plus a $1 Million Potential Milestone in Early 2014

Exhibit 99 Exhibit 99.1 InSite Vision Announces Sale of Besivance® Royalty for $15 Million Plus a $1 Million Potential Milestone in Early 2014 The Royalty May Be Returned to InSite Vision In Whole or In Part If the Buyers Receive Certain Levels of Total Cash from the Royalty ALAMEDA, Calif. - April 2, 2013 - InSite Vision Incorporated (OTCBB: INSV) today announced that it agreed to sell its royalt

March 5, 2013 EX-99.1

InSite Vision Reports Fourth Quarter and Full-Year 2012 Financial Results

EX-99.1 Exhibit 99.1 InSite Vision Reports Fourth Quarter and Full-Year 2012 Financial Results Alameda, Calif., March 5, 2013 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter and year ended December 31, 2012. Revenues for the year ended December 31, 2012 were $21.6 million compared to $15.9 million for the same period in 2011. Net loss for the year ended

March 5, 2013 8-K

Results of Operations and Financial Condition - FORM 8-K

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) March 5, 2013 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

February 15, 2013 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a statement on Schedule 13G and/or 13D (including any and all amendments thereto) with respect to Common Stock, par value $0.0001 per share, of Insite Vision Incorporated, and further agree that this Joint

February 15, 2013 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a statement on Schedule 13G and/or 13D (including any and all amendments thereto) with respect to Common Stock, par value $0.0001 per share, of Insite Vision Incorporated, and further agree that this Joint

February 15, 2013 SC 13G/A

INSV / Insite Vision Inc / Ayer Capital Management, LP - NONE Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 02)* InSite Vision Incorporated (Name of Issuer) Common Stock (Title of Class of Securities) 457660108 (CUSIP Number) Calendar Year 2012 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule purs

February 15, 2013 SC 13G/A

INSV / Insite Vision Inc / Ayer Capital Management, LP - NONE Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 02)* InSite Vision Incorporated (Name of Issuer) Common Stock (Title of Class of Securities) 457660108 (CUSIP Number) Calendar Year 2012 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

February 14, 2013 SC 13G/A

INSV / Insite Vision Inc / Broadfin Capital, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 11, 2013 S-8

- FORM S-8

Form S-8 As filed with the Securities and Exchange Commission on February 11, 2013 Registration No.

February 7, 2013 SC 13G/A

INSV / Insite Vision Inc / Jacobson Eli D - SCHEDULE 13G/A Passive Investment

Schedule 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 10)* INSITE VISION INCORPORATED (Name of Issuer) COMMON STOCK, PAR VALUE $0.01 PER SHARE (Title of Class of Securities) 457660108 (CUSIP Number) December 31, 2012 (Date of Event Which Requires Filing of this Statement) Check the appropriate

January 28, 2013 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

8-K 1 rrd367921.htm FORM 8-K - 5.02 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): 01/24/2013 InSite Vision Incorporated (Exact name of registrant as specified in its charter) Commission File Number: 0-22332 Delaware 94-3015807 (S

December 31, 2012 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

Form 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 27, 2012 INSITE VISION INCORPORATED (Exact name of registrant as specified in its charter) Delaware 000-22332 94-3015807 (State or other jurisdiction of incorporatio

December 31, 2012 EX-10.1

OPTION CANCELLATION AGREEMENT

Option Cancellation Agreement Exhibit 10.1 OPTION CANCELLATION AGREEMENT December 27, 2012 Dear Tim Ruane, This letter relates to the nonqualified stock option to acquire 2,844,374 shares of InSite Vision Incorporated (“Company”) common stock granted to you on December 1, 2010 (“2010 Option”) pursuant to the Notice of Grant of Stock Option and Terms and Conditions of Stock Option executed by you a

November 8, 2012 8-K

Results of Operations and Financial Condition - FORM 8-K

Form 8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) November 8, 2012 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

November 8, 2012 EX-99.1

InSite Vision Reports Third Quarter 2012 Financial Results

InSite Vision Incorporated Press Release Exhibit 99.1 InSite Vision Reports Third Quarter 2012 Financial Results Alameda, Calif., November 8, 2012 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter ended September 30, 2012. Total revenues for the third quarter of 2012 were $12.1 million, an increase of $5.5 million from the same quarter of 2011 primarily du

August 14, 2012 POS AM

- POST-EFFECTIVE AMENDMENT NO. 2 TO FORM S-1

Post-Effective Amendment No. 2 to Form S-1 As filed with the Securities and Exchange Commission on August 14, 2012 Registration No. 333-176057 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 2 TO FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 INSITE VISION INCORPORATED (Exact Name of Registrant As Specified In Its Charter) Dela

July 31, 2012 EX-99.1

InSite Vision Reports Second Quarter 2012 Financial Results

Press Release Exhibit 99.1 InSite Vision Reports Second Quarter 2012 Financial Results Alameda, Calif., July 31, 2012 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter ended June 30, 2012. Total revenues for the second quarter of 2012 were $1.8 million, a decrease of $1.3 million from the same quarter of 2011. InSite Vision had cash, cash equivalents and s

July 31, 2012 8-K

Results of Operations and Financial Condition

Form 8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) July 31, 2012 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

June 1, 2012 8-K

Submission of Matters to a Vote of Security Holders - 8K - 2012 SHAREHOLDER MEETING

DC12316.pdf - Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 31, 2012 INSITE VISION INCORPORATED (Exact Name of Registrant as Specified in Charter)

May 7, 2012 424B3

PROSPECTUS SUPPLEMENT NO. 1 (TO PROSPECTUS DATED MARCH 5, 2012) INSITE VISION INCORPORATED 51,546,647 Shares of Common Stock

Filed Pursuant to Rule 424(b)(3) Table of Contents Filed Pursuant to Rule 424(b)(3) Registration Statement No.

May 1, 2012 EX-99.1

InSite Vision Reports First Quarter 2012 Financial Results

InSite Vision Incorporated Press Release Exhibit 99.1 InSite Vision Reports First Quarter 2012 Financial Results Alameda, Calif., May 1, 2012 – InSite Vision Incorporated (OTCBB: INSV) today reported financial results for the quarter ended March 31, 2012. Total revenues for the first quarter of 2012 were $2.3 million, a decrease of $0.8 million from the same quarter of 2011. InSite Vision had cash

May 1, 2012 8-K

Results of Operations and Financial Condition - FORM 8-K

Form 8-K Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K Current Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 1, 2012 InSite Vision Incorporated (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdiction of Incorporation) 0-22332 94-3015807 (Commission File Number) (IRS Employer Identification No.

April 10, 2012 DEFA14A

- DEFINITIVE ADDITIONAL MATERIAL

DEFA14A 1 d332212ddefa14a.htm DEFINITIVE ADDITIONAL MATERIAL UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check

April 9, 2012 DEF 14A

- DEFINITIVE PROXY STATEMENT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confide

April 4, 2012 SC 13G/A

INSV / Insite Vision Inc / Ayer Capital Management, LP - NONE Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* InSite Vision Incorporated (Name of Issuer) Common Stock (Title of Class of Securities) 457660108 (CUSIP Number) December 31, 2011 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursua

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