BBAGF / BB Biotech AG - SEC-arkivering, Årsberetning, Fuldmagtserklæring

BB Biotech AG
US ˙ OTCPK ˙ CH0038389992

Grundlæggende statistik
LEI 391200MBZQNPFHIVKO34
CIK 924223
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to BB Biotech AG
SEC Filings (Chronological Order)
Denne side giver en komplet, kronologisk liste over SEC-arkiveringer, eksklusive ejerskabsregistreringer, som vi leverer andre steder.
December 9, 2024 SC 13G/A

GBIO / Generation Bio Co. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d891686dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* Generation Bio Co. (Name of Issuer) Common Stock (Title of Class of Securities) 37148K100 (CUSIP Number) December 5, 2024 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate t

November 18, 2024 SC 13G/A

MTEM / Molecular Templates, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d882996dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7)* MOLECULAR TEMPLATES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 608550208 (CUSIP Number) November 14, 2024 (Date of Event Which Requires Filing This Statement) Check the appropriate box to des

November 14, 2024 SC 13G/A

IONS / Ionis Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d877529dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 14)* Ionis Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 462222100 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing This Statement) Check the appropriate box to

November 14, 2024 SC 13G/A

ANNX / Annexon, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Annexon, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 03589W102 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Sc

November 14, 2024 SC 13G/A

SAGE / Sage Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d826473dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Sage Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 78667J108 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing This Statement) Check the appropriate box to desi

November 14, 2024 SC 13G/A

EPIX / ESSA Pharma Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* ESSA Pharma Inc. (Name of Issuer) Common Shares (Title of Class of Securities) 29668H708 (CUSIP Number) November 1, 2024 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

April 22, 2024 EX-99.A

Joint Filing Statement

EX-99.A 2 d807203dex99a.htm EX-99.A Exhibit A Exhibit A Joint Filing Statement We, the undersigned, hereby express our agreement that the attached Schedule 13G (including all amendments thereto) is filed on behalf of each of the undersigned. BB Biotech AG Date: April 22, 2024 By: /s/ Martin Gubler Signatory Authority Name: Martin Gubler Title: Signatory Authority Date: April 22, 2024 By: /s/ Ivo B

April 22, 2024 SC 13G

ANNX / Annexon, Inc. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G 1 d807203dsc13g.htm SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Annexon, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 03589W102 (CUSIP Number) April 17, 2024 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 13, 2024 SC 13G/A

US6085502085 / Molecular Templates, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d40123dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6)* MOLECULAR TEMPLATES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 608550208 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing This Statement) Check the appropriate box to desi

February 13, 2024 SC 13G/A

GBIO / Generation Bio Co. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Generation Bio Co. (Name of Issuer) Common Stock (Title of Class of Securities) 37148K100 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which thi

February 13, 2024 SC 13G/A

AGIO / Agios Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d687782dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 10)* AGIOS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 00847X104 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing This Statement) Check the appropriate box to

February 13, 2024 SC 13G/A

WVE / Wave Life Sciences Ltd. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d740975dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* WAVE LIFE SCIENCES LTD. (Name of Issuer) Ordinary Shares (Title of Class of Securities) Y95308105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing This Statement) Check the appropriate box to de

February 13, 2024 SC 13G/A

BDTX / Black Diamond Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d771535dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* Black Diamond Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 09203E105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing This Statement) Check the appropriate box

February 13, 2024 SC 13G/A

RVMD / Revolution Medicines, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Revolution Medicines, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 76155X100 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing This Statement) Check the appropriate box to des

February 13, 2024 SC 13G/A

SAGE / Sage Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d728625dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 (Amendment No. 1)* SCHEDULE 13G Under the Securities Exchange Act of 1934 Sage Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 78667J108 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing This Statement) Check the appropriate box to desig

February 13, 2024 SC 13G/A

EPIX / ESSA Pharma Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* ESSA Pharma Inc. (Name of Issuer) Common Shares (Title of Class of Securities) 29668H708 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 13, 2024 SC 13G/A

IONS / Ionis Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d749650dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 13)* IONIS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 462222100 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing This Statement) Check the appropriate box to

February 13, 2024 EX-99.A

Joint Filing Statement

EX-99.A Exhibit A Joint Filing Statement We, the undersigned, hereby express our agreement that the attached Schedule 13G (including all amendments thereto) is filed on behalf of each of the undersigned. BB Biotech AG Date: February 6, 2024 By: /s/ Martin Gubler Signatory Authority Name: Martin Gubler Title: Signatory Authority Date: February 6, 2024 By: /s/ Ivo Betschart Signatory Authority Name:

February 13, 2024 SC 13G/A

MGNX / MacroGenics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d771056dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 9)* MACROGENICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 556099109 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate t

January 24, 2024 SC 13G/A

ESPR / Esperion Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 11)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) January 19, 2024 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

January 24, 2024 SC 13G/A

ESPR / Esperion Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 10)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 17, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 3 d459172dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 17, 2023 EX-99.A

Joint Filing Statement

EX-99.A 2 d459172dex99a.htm EX-99.A Exhibit A Joint Filing Statement We, the undersigned, hereby express our agreement that the attached Schedule 13G (including all amendments thereto) is filed on behalf of each of the undersigned. BB Biotech AG Date: February 17, 2023 By: /s/ Martin Gubler Signatory Authority Name: Martin Gubler Title: Signatory Authority Date: February 17, 2023 By: /s/ Ivo Betsc

February 17, 2023 SC 13G

SAGE / SAGE Therapeutics Inc / BB BIOTECH AG - SC 13G Passive Investment

SC 13G 1 d459172dsc13g.htm SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Sage Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 78667J108 (CUSIP Number) February 9, 2023 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d398847dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d405438dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d400612dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d405844dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 SC 13G/A

MGNX / MacroGenics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d401652dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 8)* MACROGENICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 556099109 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate t

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d406969dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d443320dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 SC 13G/A

RVMD / Revolution Medicines Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d443320dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* REVOLUTION MEDICINES, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 76155X100 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Ch

February 14, 2023 SC 13G/A

MYOV / Myovant Sciences Ltd. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d398847dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7)* MYOVANT SCIENCES LTD. (Name of Issuer) Common Shares (Title of Class of Securities) G637AM102 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box to design

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d407274dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 SC 13G/A

KZR / Kezar Life Sciences Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d408330dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* KEZAR LIFE SCIENCES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 49372L100 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box to des

February 14, 2023 SC 13G/A

SRRK / Scholar Rock Holding Corp / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d405844dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* SCHOLAR ROCK HOLDING CORPORATION (Name of Issuer) Common Stock (Title of Class of Securities) 80706P103 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box

February 14, 2023 SC 13G/A

IONS / Ionis Pharmaceuticals Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d394406dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 12)* IONIS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 462222100 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box to

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d401652dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d394406dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d401650dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 SC 13G/A

ESPR / Esperion Therapeutics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 9)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 14, 2023 SC 13G/A

SAGE / SAGE Therapeutics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d401650dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Sage Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 78667J108 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box to desig

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d408330dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 SC 13G/A

WVE / Wave Life Sciences Ltd / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d400612dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* WAVE LIFE SCIENCES LTD. (Name of Issuer) Ordinary Shares (Title of Class of Securities) Y95308105 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box to de

February 14, 2023 SC 13G/A

MTEM / Molecular Templates Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d407274dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* MOLECULAR TEMPLATES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 608550109 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box to des

February 14, 2023 SC 13G/A

MRSN / Mersana Therapeutics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d466514dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Mersana Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 59045L106 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the ap

February 14, 2023 SC 13G/A

BDTX / Black Diamond Therapeutics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d417171dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Black Diamond Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 09203E105 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box

February 14, 2023 SC 13G/A

EPIX / ESSA Pharma Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d406969dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* ESSA Pharma Inc. (Name of Issuer) Common Shares (Title of Class of Securities) 29668H708 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate t

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d398220dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d398218dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 SC 13G/A

GBIO / Generation Bio Co / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Generation Bio Co. (Name of Issuer) Common Stock (Title of Class of Securities) 37148K100 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which thi

February 14, 2023 SC 13G/A

AGIO / Agios Pharmaceuticals Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d398218dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 9)* AGIOS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 00847X104 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box to d

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d466514dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

February 14, 2023 EX-99.B

POWER OF ATTORNEY

EX-99.B 2 d417171dex99b.htm EX-99.B Exhibit B POWER OF ATTORNEY The Undersigned, Hugo van Neutegem herewith gives Power of Attorney to Mrs. Nathalie M.A. Isidora-Kwidama, born in Curacao on, holder of a passport issued by the Kingdom of the Netherlands, with number, to represent the Company in the broadest sense of the word and in the best interest of the Company and further to do if were the Unde

September 30, 2022 SC 13G

RVMD / Revolution Medicines Inc / BB BIOTECH AG - SC 13G Passive Investment

SC 13G 1 d290834dsc13g.htm SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 REVOLUTION MEDICINES, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 76155X100 (CUSIP Number) September 22, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box

September 30, 2022 EX-99.A

Joint Filing Statement

Exhibit A Joint Filing Statement We, the undersigned, hereby express our agreement that the attached Schedule 13G (including all amendments thereto) is filed on behalf of each of the undersigned.

August 30, 2022 SC 13D/A

RDUS / Radius Health Inc / BB BIOTECH AG - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 14)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 750469207 (CUSIP Number) BB Biotech AG Ivo Betschart Schwertstrasse 6 CH-8200 Schaffhausen, Switzerland +41 44 267 67 00 (Name, Address and Telephone Num

April 14, 2022 SC 13G/A

BDTX / Black Diamond Therapeutics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Black Diamond Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 09203E105 (CUSIP Number) April 11, 2022 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which t

February 11, 2022 SC 13G/A

ESPR / Esperion Therapeutics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 8)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which thi

February 11, 2022 SC 13G/A

AGIO / Agios Pharmaceuticals Inc / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 8)* AGIOS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 00847X104 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which thi

February 11, 2022 SC 13G/A

CDTX / Cidara Therapeutics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7)* CIDARA THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 171757107 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 11, 2022 SC 13G/A

VYGR / Voyager Therapeutics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* VOYAGER THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 92915B106 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 11, 2022 SC 13G/A

MYOV / Myovant Sciences Ltd. / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6)* MYOVANT SCIENCES LTD. (Name of Issuer) Common Shares (Title of Class of Securities) G637AM102 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Sch

February 11, 2022 SC 13G/A

WVE / Wave Life Sciences Ltd / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* WAVE LIFE SCIENCES LTD. (Name of Issuer) Ordinary Shares (Title of Class of Securities) Y95308105 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 11, 2022 SC 13G/A

MTEM / Molecular Templates Inc / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* MOLECULAR TEMPLATES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 608550109 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 11, 2022 SC 13G/A

IONS / Ionis Pharmaceuticals Inc / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 11)* IONIS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 462222100 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which th

February 11, 2022 SC 13G/A

KZR / Kezar Life Sciences Inc / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* KEZAR LIFE SCIENCES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 49372L100 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 11, 2022 SC 13G/A

MGNX / MacroGenics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7)* MACROGENICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 556099109 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

February 11, 2022 SC 13G/A

BDTX / Black Diamond Therapeutics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Black Diamond Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 09203E105 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to whic

February 11, 2022 SC 13G/A

GBIO / Generation Bio Co / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Generation Bio Co. (Name of Issuer) Common Stock (Title of Class of Securities) 37148K100 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which thi

February 11, 2022 SC 13G/A

SAGE / SAGE Therapeutics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d283396dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Sage Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 78667J108 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to desig

February 11, 2022 SC 13G/A

SRRK / Scholar Rock Holding Corp / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d283398dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* SCHOLAR ROCK HOLDING CORPORATION (Name of Issuer) Common Stock (Title of Class of Securities) 80706P103 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box

February 11, 2022 SC 13G/A

EPIX / ESSA Pharma Inc / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* ESSA Pharma Inc. (Name of Issuer) Common Shares (Title of Class of Securities) 29668H708 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

January 18, 2022 SC 13D/A

RDUS / Radius Health Inc / BB BIOTECH AG - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 13)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 750469207 (CUSIP Number) BB Biotech AG Ivo Betschart Schwertstrasse 6 CH-8200 Schaffhausen, Switzerland +41 44 267 67 00 (Name, Address and Telephone Num

September 16, 2021 SC 13G

MRSN / Mersana Therapeutics Inc / BB BIOTECH AG - SC 13G Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 MERSANA THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 59045L106 (CUSIP Number) September 10, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

August 17, 2021 SC 13G/A

EPIX / ESSA Pharma Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d220304dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* ESSA Pharma Inc. (Name of Issuer) Common Shares (Title of Class of Securities) 29668H708 (CUSIP Number) August 16, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the

August 11, 2021 SC 13G

SAGE / SAGE Therapeutics Inc / BB BIOTECH AG - SC 13G Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Sage Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 78667J108 (CUSIP Number) August 4, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which

June 11, 2021 SC 13G/A

MGNX / MacroGenics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6)* MACROGENICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 556099109 (CUSIP Number) June 9, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Sche

May 28, 2021 SC 13G/A

ESPR / Esperion Therapeutics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d174120dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) May 19, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to design

May 27, 2021 SC 13G/A

ESPR / Esperion Therapeutics Inc / BB BIOTECH AG - SC 13G/A Passive Investment

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) May 19, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Sch

May 5, 2021 SC 13G

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 ESSA Pharma Inc. (Name of Issuer) Common Shares (Title of Class of Securities) (CUSIP Number) April 29, 2021 (Date of Event

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 ESSA Pharma Inc. (Name of Issuer) Common Shares (Title of Class of Securities) 29668H708 (CUSIP Number) April 29, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ☐ Ru

April 26, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* MOLECULAR TEMPLATES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) Ap

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* MOLECULAR TEMPLATES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 608550109 (CUSIP Number) April 7, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* KEZAR LIFE SCIENCES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) De

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* KEZAR LIFE SCIENCES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 49372L100 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* INTRA-CELLULAR THERAPIES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Numbe

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* INTRA-CELLULAR THERAPIES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 46116X101 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* MACROGENICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) December 3

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* MACROGENICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 556099109 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* VOYAGER THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) D

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* VOYAGER THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 92915B106 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* WAVE LIFE SCIENCES LTD. (Name of Issuer) Ordinary Shares (Title of Class of Securities) (CUSIP Number) D

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* WAVE LIFE SCIENCES LTD. (Name of Issuer) Ordinary Shares (Title of Class of Securities) Y95308105 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to w

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* MOLECULAR TEMPLATES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) De

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* MOLECULAR TEMPLATES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 608550109 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to wh

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 10)* IONIS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number)

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 10)* IONIS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 462222100 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which th

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7)* HALOZYME THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number)

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7)* HALOZYME THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 40637H109 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7)* AGIOS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number)

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7)* AGIOS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 00847X104 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which thi

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* MYOVANT SCIENCES LTD. (Name of Issuer) Common Shares (Title of Class of Securities) (CUSIP Number) Decem

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* MYOVANT SCIENCES LTD. (Name of Issuer) Common Shares (Title of Class of Securities) G637AM102 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* SCHOLAR ROCK HOLDING CORPORATION (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Num

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* SCHOLAR ROCK HOLDING CORPORATION (Name of Issuer) Common Stock (Title of Class of Securities) 80706P103 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuan

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6)* CIDARA THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) De

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6)* CIDARA THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 171757107 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 12, 2021 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number)

SC 13G/A 1 d124139dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to d

February 11, 2021 SC 13G

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Black Diamond Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) February 3, 20

SC 13G 1 d103037dsc13g.htm SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Black Diamond Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 09203E105 (CUSIP Number) February 3, 2021 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pu

January 8, 2021 SC 13G

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Generation Bio Co. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) December 31, 2020 (Date of E

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Generation Bio Co. (Name of Issuer) Common Stock (Title of Class of Securities) 37148K100 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

November 17, 2020 SC 13D/A

RDUS / Radius Health, Inc. / BB BIOTECH AG - SC 13D/A Activist Investment

SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 12)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 750469207 (CUSIP Number) BB Biotech AG Ivo Betschart Schwertstrasse 6 CH-8200 Schaffhausen, Switzerland +41 44 267 67 00 (Name, Address and Tele

November 4, 2020 SC 13G/A

MTEM / Molecular Templates, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* MOLECULAR TEMPLATES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 608550109 (CUSIP Number) October 26, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to whi

May 19, 2020 SC 13D/A

RDUS / Radius Health, Inc. / BB BIOTECH AG - SC 13D/A Activist Investment

SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 11)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 750469207 (CUSIP Number) BB Biotech AG Ivo Betschart Schwertstrasse 6 CH-8200 Schaffhausen, Switzerland +41 44 267 67 00 (Name, Address and Tele

February 14, 2020 SC 13G/A

KZR / Kezar Life Sciences, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* KEZAR LIFE SCIENCES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 49372L100 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to wh

February 14, 2020 SC 13G/A

ESPR / Esperion Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 14, 2020 SC 13G/A

MYOV / Myovant Sciences Ltd. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* MYOVANT SCIENCES LTD. (Name of Issuer) Common Shares (Title of Class of Securities) G637AM102 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which

February 14, 2020 SC 13G/A

WVE / WAVE Life Sciences Ltd. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* WAVE LIFE SCIENCES LTD. (Name of Issuer) Ordinary Shares (Title of Class of Securities) Y95308105 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to w

February 14, 2020 SC 13G/A

VYGR / Voyager Therapeutics, Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* VOYAGER THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 92915B106 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to w

February 14, 2020 SC 13G/A

AGIO / Agios Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6)* AGIOS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 00847X104 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 14, 2020 SC 13G/A

IONS / Ionis Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 9)* IONIS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 462222100 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 14, 2020 SC 13G/A

SRRK / Scholar Rock Holding Corporation / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* SCHOLAR ROCK HOLDING CORPORATION (Name of Issuer) Common Stock (Title of Class of Securities) 80706P103 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuan

February 14, 2020 SC 13G/A

HALO / Halozyme Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6)* HALOZYME THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 40637H109 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 14, 2020 SC 13G/A

CDTX / Cidara Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d835875dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* CIDARA THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 171757107 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to des

February 14, 2020 SC 13G/A

MGNX / MacroGenics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* MACROGENICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 556099109 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 6, 2020 SC 13G

ITCI / Intra-Cellular Therapies Inc. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 INTRA-CELLULAR THERAPIES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 46116X101 (CUSIP Number) January 30, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

January 29, 2020 SC 13G

THLD / Threshold Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 MOLECULAR TEMPLATES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 608550109 (CUSIP Number) January 24, 2020 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is f

December 23, 2019 SC 13G

WVE / WAVE Life Sciences Ltd. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 WAVE LIFE SCIENCES LTD. (Name of Issuer) Common Stock (Title of Class of Securities) Y95308105 (CUSIP Number) December 17, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is fi

February 13, 2019 SC 13G/A

TSRO / TESARO, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* TESARO, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 881569107 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Sche

February 13, 2019 SC 13G/A

ESPR / Esperion Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d704774dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing This Statement) Check the appropriate box to d

February 13, 2019 SC 13G/A

MYOV / Myovant Sciences Ltd. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d693268dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* MYOVANT SCIENCES LTD. (Name of Issuer) Common Stock (Title of Class of Securities) G637AM102 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designa

February 13, 2019 SC 13G/A

HALO / Halozyme Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* HALOZYME THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 40637H109 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 13, 2019 SC 13G/A

MGNX / MacroGenics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d695656dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* MACROGENICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 556099109 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate t

February 13, 2019 SC 13G/A

VYGR / Voyager Therapeutics, Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* VOYAGER THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 92915B106 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to w

February 13, 2019 SC 13G/A

CDTX / Cidara Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* CIDARA THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 171757107 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to wh

February 13, 2019 SC 13G/A

IONS / Ionis Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 8)* IONIS PHARMACEUTICALS, INC. (formerly Isis Pharmaceuticals, Inc.) (Name of Issuer) Common Stock (Title of Class of Securities) 462222100 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing This Statement) Check the appropriate

January 31, 2019 SC 13G

KZR / Kezar Life Sciences, Inc. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G 1 d663526dsc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 KEZAR LIFE SCIENCES, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 49372L100 (CUSIP Number) January 28, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant

January 28, 2019 SC 13G/A

AGIO / Agios Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d697775dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* AGIOS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 00847X104 (CUSIP Number) January 22, 2019 (Date of Event Which Requires Filing This Statement) Check the appropriate box to de

January 7, 2019 SC 13G

SRRK / Scholar Rock Holding Corporation / BB BIOTECH AG - SC 13G Passive Investment

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 SCHOLAR ROCK HOLDING CORPORATION (Name of Issuer) Common Stock (Title of Class of Securities) 80706P103 (CUSIP Number) December 28, 2018 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Sched

August 13, 2018 SC 13G

TSRO / TESARO, Inc. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 TESARO, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 881569107 (CUSIP Number) August 8, 2018 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ☐ Rule 13

August 6, 2018 SC 13D/A

RDUS / Radius Health, Inc. / BB BIOTECH AG - SC 13D/A Activist Investment

SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 10)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 750469108 (CUSIP Number) BB Biotech AG Ivo Betschart Schwertstrasse 6 CH-8200 Schaffhausen, Switzerland +41 44 267 67 00 (Name, Address and Tele

May 10, 2018 SC 13G/A

ESPR / Esperion Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) May 3, 2018 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which

February 14, 2018 SC 13G/A

MYOV / Myovant Sciences Ltd. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* MYOVANT SCIENCES LTD. (Name of Issuer) Common Stock (Title of Class of Securities) G637AM102 (CUSIP Number) December 31, 2017 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which

February 14, 2018 SC 13G/A

AGIO / Agios Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* AGIOS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 00847X104 (CUSIP Number) December 31, 2017 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 14, 2018 SC 13G/A

IONS / Ionis Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7)* IONIS PHARMACEUTICALS, INC. (formerly Isis Pharmaceuticals, Inc.) (Name of Issuer) Common Stock (Title of Class of Securities) 462222100 (CUSIP Number) December 31, 2017 (Date of Event Which Requires Filing This Statement) Check the appropriate

February 14, 2018 SC 13G/A

MGNX / MacroGenics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* MACROGENICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 556099109 (CUSIP Number) December 31, 2017 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 14, 2018 SC 13G/A

ESPR / Esperion Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) December 31, 2017 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 14, 2018 SC 13G/A

CDTX / Cidara Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* CIDARA THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 171757107 (CUSIP Number) December 31, 2017 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to wh

February 14, 2018 SC 13G/A

ITCI / Intra-Cellular Therapies Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d488190dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* INTRA-CELLULAR THERAPIES INC. (Name of Issuer) Common Stock (Title of Class of Securities) 46116X101 (CUSIP Number) December 31, 2017 (Date of Event Which Requires Filing This Statement) Check the appropriate box to

February 14, 2018 SC 13G/A

HALO / Halozyme Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* HALOZYME THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 40637H109 (CUSIP Number) December 31, 2017 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

January 10, 2018 SC 13G

VYGR / Voyager Therapeutics, Inc / BB BIOTECH AG - SC 13G Passive Investment

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 VOYAGER THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 92915B106 (CUSIP Number) January 3, 2018 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is f

October 27, 2017 SC 13G/A

CDTX / Cidara Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* CIDARA THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 171757107 (CUSIP Number) October 24, 2017 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to whi

September 20, 2017 SC 13D/A

Radius Health SC 13D/A (Activist Acquisition of More Than 5% of Shares)

SC 13D/A 1 d456933dsc13da.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 9)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 750469108 (CUSIP Number) BB Biotech AG Ivo Betschart Schwertstrasse 6 CH-8200 Schaffhausen, Switzerland +41 44 267

August 23, 2017 SC 13G

ITCI / Intra-Cellular Therapies Inc. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 INTRA-CELLULAR THERAPIES INC. (Name of Issuer) Common Stock (Title of Class of Securities) 46116X101 (CUSIP Number) August 18, 2017 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule i

June 1, 2017 SC 13D/A

RDUS / Radius Health, Inc. / BB BIOTECH AG - SC 13D/A Activist Investment

SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 8)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 750469108 (CUSIP Number) BB Biotech AG Ivo Betschart Schwertstrasse 6 CH-8200 Schaffhausen, Switzerland +41 44 267 67 00 (Name, Address and Telep

March 22, 2017 SC 13D/A

Radius Health SC 13D/A (Activist Acquisition of More Than 5% of Shares)

SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 7)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 750469108 (CUSIP Number) BB Biotech AG Ivo Betschart Schwertstrasse 6 CH-8200 Schaffhausen, Switzerland +41 44 267 67 00 (Name, Address and Telep

February 14, 2017 SC 13G/A

IONS / Ionis Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6)* IONIS PHARMACEUTICALS, INC. (formerly Isis Pharmaceuticals, Inc.) (Name of Issuer) Common Stock (Title of Class of Securities) 462222100 (CUSIP Number) December 31, 2016 (Date of Event Which Requires Filing This Statement) Check the appropriate

February 14, 2017 SC 13G/A

Cidara Therapeutics SC 13G/A (Passive Acquisition of More Than 5% of Shares)

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* CIDARA THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 171757107 (CUSIP Number) December 31, 2016 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to wh

February 14, 2017 SC 13G/A

MYOV / Myovant Sciences Ltd. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d331389dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* MYOVANT SCIENCES LTD. (Name of Issuer) Common Stock (Title of Class of Securities) G637AM102 (CUSIP Number) December 31, 2016 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designa

February 14, 2017 SC 13G/A

HALO / Halozyme Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d340919dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* HALOZYME THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 40637H109 (CUSIP Number) December 31, 2016 (Date of Event Which Requires Filing This Statement) Check the appropriate box to d

February 14, 2017 SC 13G/A

AGIO / Agios Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* AGIOS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 00847X104 (CUSIP Number) December 31, 2016 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 14, 2017 SC 13G/A

MGNX / MacroGenics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* MACROGENICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 556099109 (CUSIP Number) December 31, 2016 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

February 14, 2017 SC 13G/A

ESPR / Esperion Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) December 31, 2016 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 14, 2017 SC 13G/A

INFI / Infinity Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* INFINITY PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 45665G303 (CUSIP Number) December 31, 2016 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant

December 29, 2016 SC 13G

MGNX / MacroGenics, Inc. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 MACROGENICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 556099109 (CUSIP Number) December 28, 2016 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ☐

December 28, 2016 SC 13G

MYOV / Myovant Sciences Ltd. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 MYOVANT SCIENCES LTD. (Name of Issuer) Common Stock (Title of Class of Securities) G637AM102 (CUSIP Number) December 23, 2016 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is file

September 27, 2016 SC 13G

ESPR / Esperion Therapeutics, Inc. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 ESPERION THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29664W105 (CUSIP Number) September 22, 2016 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

April 4, 2016 SC 13G

Cidara Therapeutics SC 13G (Passive Acquisition of More Than 5% of Shares)

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 CIDARA THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 171757107 (CUSIP Number) March 31, 2016 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is fil

April 4, 2016 EX-99.A

Joint Filing Statement

EX-99.A 2 d168694dex99a.htm EX-99.A Exhibit A Joint Filing Statement We, the undersigned, hereby express our agreement that the attached Schedule 13G (including all amendments thereto) is filed on behalf of each of the undersigned. BB Biotech AG Date: April 4, 2016 By: /s/ Michael Hutter Signatory Authority Name: Michael Hutter Title: Signatory Authority Date: April 4, 2016 By: /s/ Ivo Betschart S

February 9, 2016 SC 13G/A

IONS / Ionis Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d128192dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* IONIS PHARMACEUTICALS, INC. ( formerly Isis Pharmaceuticals, Inc.) (Name of Issuer) Common Stock (Title of Class of Securities) 462222100 (CUSIP Number) December 31, 2015 (Date of Event Which Requires Filing This St

February 9, 2016 SC 13G/A

HALO / Halozyme Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d128192dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* HALOZYME THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 40637H109 (CUSIP Number) December 31, 2015 (Date of Event Which Requires Filing This Statement) Check the appropriate box to d

February 9, 2016 SC 13G/A

INFI / Infinity Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d128192dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1) INFINITY PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 45665G303 (CUSIP Number) December 31, 2015 (Date of Event Which Requires Filing This Statement) Check the appropriate box to

February 9, 2016 SC 13G/A

AGIO / Agios Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* AGIOS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 00847X104 (CUSIP Number) December 31, 2015 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 13, 2015 SC 13G/A

HALO / Halozyme Therapeutics, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d872868dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* HALOZYME THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 40637H109 (CUSIP Number) December 31, 2014 (Date of Event Which Requires Filing This Statement) Check the appropriate box to d

February 12, 2015 SC 13G/A

ECYT / Endocyte, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3; Exit Filing)* ENDOCYTE, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29269A102 (CUSIP Number) December 31, 2014 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to

February 12, 2015 SC 13G/A

IONS / Ionis Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* ISIS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 464330109 (CUSIP Number) December 31, 2014 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to w

February 12, 2015 SC 13G/A

AGIO / Agios Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d872868dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* AGIOS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 00847X104 (CUSIP Number) December 31, 2014 (Date of Event Which Requires Filing This Statement) Check the appropriate box to d

January 13, 2015 SC 13G

INFI / Infinity Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 INFINITY PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 45665G303 (CUSIP Number) January 8, 2015 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

September 11, 2014 SC 13G

AGIO / Agios Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G 1 d787834dsc13g.htm SC 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 AGIOS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 00847X104 (CUSIP Number) September 9, 2014 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursua

August 7, 2014 SC 13G

HALO / Halozyme Therapeutics, Inc. / BB BIOTECH AG - SCHEDULE 13G Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 HALOZYME THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 40637H109 (CUSIP Number) August 1, 2014 (Date of Event Which Requires Filing this Statement) Check the appropriate box to designate the rule pursuant to which this Schedul

June 12, 2014 SC 13D/A

RDUS / Radius Health, Inc. / BB BIOTECH AG - SC 13D/A Activist Investment

SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 6)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 750469108 (CUSIP Number) BB Biotech AG Ivo Betschart Vordergasse 3 CH-8200 Schaffhausen, Switzerland +41 44 267 67 21 (Name, Address and Telephon

March 5, 2014 SC 13D/A

RDUS / Radius Health, Inc. / BB BIOTECH AG - SCHEDULE 13D AMENDMENT NO. 5 Activist Investment

SC 13D/A 1 d688904dsc13da.htm SCHEDULE 13D AMENDMENT NO. 5 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 5)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 750469108 (CUSIP Number) BB Biotech AG Ivo Betschart Vordergasse 3 CH-8200 Schaffhausen, Switze

February 12, 2014 SC 13G/A

HALO / Halozyme Therapeutics, Inc. / BB BIOTECH AG - AMENDMENT NO. 1 TO SCHEDULE 13G Passive Investment

Amendment No. 1 to Schedule 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* HALOZYME THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 40637H109 (CUSIP Number) December 31, 2013 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designat

February 12, 2014 SC 13G/A

ECYT / Endocyte, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* ENDOCYTE, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29269A102 (CUSIP Number) December 31, 2013 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Sc

February 12, 2014 SC 13G/A

IONS / Ionis Pharmaceuticals, Inc. / BB BIOTECH AG - AMENDMENT NO. 3 TO SCHEDULE 13G Passive Investment

SC 13G/A 1 d674849dsc13ga.htm AMENDMENT NO. 3 TO SCHEDULE 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* ISIS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 464330109 (CUSIP Number) December 31, 2013 (Date of Event Which Requires Filing This Statement) Check th

August 14, 2013 SC 13G

HALO / Halozyme Therapeutics, Inc. / BB BIOTECH AG - SC 13G Passive Investment

SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 HALOZYME THERAPEUTICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 40637H109 (CUSIP Number) August 5, 2013 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule i

May 3, 2013 SC 13D/A

RDUS / Radius Health, Inc. / BB BIOTECH AG - SCHEDULE 13D AMENDMENT NO. 4 Activist Investment

Schedule 13D Amendment No. 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 4)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 750469108 (CUSIP Number) BB Biotech AG Pascal Schmucki Vordergasse 3 CH-8200 Schaffhausen, Switzerland +41 44 267 67 21 (Name

February 13, 2013 SC 13G/A

ECYT / Endocyte, Inc. / BB BIOTECH AG - SCHEDULE 13G AMENDMENT NO. 1 Passive Investment

Schedule 13G Amendment No. 1 United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* ENDOCYTE, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29269A102 (CUSIP Number) December 31, 2012 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursu

February 13, 2013 SC 13G/A

IONS / Ionis Pharmaceuticals, Inc. / BB BIOTECH AG - SCHEDULE 13G AMENDMENT NO. 2 Passive Investment

SC 13G/A 1 d485974dsc13ga.htm SCHEDULE 13G AMENDMENT NO. 2 United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* ISIS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 464330109 (CUSIP Number) December 31, 2012 (Date of Event Which Requires Filing This Statement) Check the a

February 13, 2013 SC 13G/A

IMGN / Immunogen, Inc. / BB BIOTECH AG - SCHEDULE 13G AMENDMENT NO. 3 Passive Investment

SC 13G/A 1 d485974dsc13ga.htm SCHEDULE 13G AMENDMENT NO. 3 United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* IMMUNOGEN, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 45253H101 (CUSIP Number) December 31, 2012 (Date of Event Which Requires Filing This Statement) Check the appropriate

August 8, 2012 SC 13G

ECYT / Endocyte, Inc. / BB BIOTECH AG - SCHEDULE 13G Passive Investment

Schedule 13G United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 ENDOCYTE, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 29269A102 (CUSIP Number) August 1, 2012 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ¨

February 7, 2012 SC 13G/A

OPTR / Optimer Pharmaceuticals Inc / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* OPTIMER PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 68401H104 (CUSIP Number) December 31, 2011 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant t

February 7, 2012 SC 13G/A

IONS / Ionis Pharmaceuticals, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Isis Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 464330109 (CUSIP Number) December 31, 2011 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to w

February 7, 2012 SC 13G/A

IMGN / Immunogen, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A 1 d296084dsc13ga.htm SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* IMMUNOGEN, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 45253H101 (CUSIP Number) December 31, 2011 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the

February 7, 2012 SC 13G/A

MITI / Micromet, Inc. / BB BIOTECH AG - SC 13G/A Passive Investment

SC 13G/A United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* MICROMET, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 59509C105 (CUSIP Number) December 31, 2011 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Sc

January 3, 2012 SC 13D/A

RDUS / Radius Health, Inc. / BB BIOTECH AG - AMENDMENT #3 TO SCHEDULE 13D Activist Investment

Amendment #3 to Schedule 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

December 23, 2011 SC 13D/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) (CUS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) None (CUSIP Number) BB Biotech AG Pascal Schmucki Vordergasse 3 CH-8200 Schaffhausen, Switzerland +41 44 267 67 21 (Name, Address and Telephone Number of

November 29, 2011 SC 13D/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) (CUS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) None (CUSIP Number) BB Biotech AG Pascal Schmucki Vordergasse 3 CH-8200 Schaffhausen, Switzerland +41 44 267 67 21 (Name, Address and Telephone Number of

July 20, 2011 SC 13G

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Isis Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) July 14, 2011 (Date

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Isis Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 464330109 (CUSIP Number) July 14, 2011 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: o R

June 3, 2011 SC 13D

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. __)* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) (CU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Radius Health, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) None (CUSIP Number) BB Biotech AG Pascal Schmucki Vordergasse 3 CH-8200 Schaffhausen, Switzerland +41 44 267 67 21 (Name, Address and Telephone Number of P

February 10, 2011 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* IMMUNOGEN, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) December 31,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* IMMUNOGEN, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 45253H101 (CUSIP Number) December 31, 2010 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule i

February 10, 2011 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* OPTIMER PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* OPTIMER PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 68401H104 (CUSIP Number) December 31, 2010 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which t

February 10, 2011 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* MICROMET, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) December 31,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* MICROMET, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 59509C105 (CUSIP Number) December 31, 2010 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is

February 10, 2011 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* ARENA PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* ARENA PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 040047102 (CUSIP Number) December 31, 2010 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which thi

August 23, 2010 SC 13G

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Optimer Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) August 13, 2010 (

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Optimer Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 68401H104 (CUSIP Number) August 13, 2010 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed

May 14, 2010 SC 13G

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 ImmunoGen, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) May 7, 2010 (Date of Event Whic

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 ImmunoGen, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 45253H101 (CUSIP Number) May 7, 2010 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: o Rule 13d-1(b)

March 22, 2010 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Micromet, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) March 12, 2010 (Date of Event Wh

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Micromet, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 59509C105 (CUSIP Number) March 12, 2010 (Date of Event Which Requires Filing this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: o Rule 13d-1(b

February 11, 2009 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* ZYMOGENETICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) December

sc13gza UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* ZYMOGENETICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 98985T109 (CUSIP Number) December 31, 2008 (Date of Event Which Requires Filing this Statement) Check the appropriate box to designate the rule pursuant to which this

January 30, 2009 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 ARENA PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) January 20, 2009 (D

sc13g UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 ARENA PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 040047102 (CUSIP Number) January 20, 2009 (Date of Event Which Requires Filing this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is

January 31, 2008 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* ZYMOGENETICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 98985T109 (CUSIP Number)

sc13gza United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* ZYMOGENETICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 98985T109 (CUSIP Number) December 31, 2007 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

December 12, 2007 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* ZYMOGENETICS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) December 3

OMB APPROVAL OMB Number: 3235-0145 Expires: February 28, 2009 Estimated average burden hours per response.

April 10, 2007 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* ANADYS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number)

OMB APPROVAL OMB Number: 3235-0145 Expires: February 28, 2009 Estimated average burden hours per response.

February 14, 2007 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* ANADYS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Numbe

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* ANADYS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 03252Q408 (CUSIP Number) December 31, 2006 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which

November 9, 2006 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 7)* The Medicines Company (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) Octobe

OMB APPROVAL OMB Number: 3235-0145 Expires: February 28, 2009 Estimated average burden hours per response.

February 14, 2006 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* AUXILIUM PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Numbe

OMB APPROVAL OMB Number: 3235-0145 Expires: February 28, 2006 Estimated average burden hours per response.

February 14, 2006 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* ANADYS PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number)

OMB APPROVAL OMB Number: 3235-0145 Expires: February 28, 2006 Estimated average burden hours per response.

February 14, 2006 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 6)* The Medicines Company (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) Decemb

OMB APPROVAL OMB Number: 3235-0145 Expires: February 28, 2006 Estimated average burden hours per response.

February 13, 2006 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* OSI PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) Fe

OMB APPROVAL OMB Number: 3235-0145 Expires: February 28, 2006 Estimated average burden hours per response.

December 1, 2005 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* OSI PHARMACEUTICALS, INC.

sc13g OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

September 19, 2005 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 ANADYS PHARMACEUTICALS, INC.

sc13g OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

June 6, 2005 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* EYETECH PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Numb

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* EYETECH PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 302297106 (CUSIP Number) May 24, 2005 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which this

March 22, 2005 EX-99.A

Joint Filing Statement

EX-99.A 2 w06923exv99wa.htm EXHIBIT 99.A EXHIBIT A Exhibit A Joint Filing Statement Pursuant to Rule 13d-1(k)(1), we, the undersigned, hereby express our agreement that the attached Schedule 13G (including all amendments thereto) is filed on behalf of each of the undersigned. BB Biotech AG Date: March 22, 2005 By: /s/ Pascal Schmucki Signatory Authority Name: Pascal Schmucki Title: Signatory Autho

March 22, 2005 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)*

sc13gza OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

February 14, 2005 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* ViroLogic, Inc.

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

February 14, 2005 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* EYETECH PHARMACEUTICALS, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* EYETECH PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 302297106 (CUSIP Number) December 31, 2004 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant to which th

February 14, 2005 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* AUXILIUM PHARMACEUTICALS, INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* AUXILIUM PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 05334D107 (CUSIP Number) December 31, 2004 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to whic

January 20, 2005 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* LIGAND PHARMACEUTICALS INCORPORATED

sc13gza OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

December 21, 2004 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* ViroLogic, Inc.

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

December 8, 2004 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Pozen, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) (CU

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Pozen, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 73941U102 (CUSIP Number) December 2, 2004 (Date of Event Which Requires Filing This Statement) Check the appropriate box to designate the rule pursuant t

November 12, 2004 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)*

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

October 21, 2004 SC 13G/A

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response. . . 11 United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendmen

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

August 4, 2004 SC 13G/A

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response. . . 11 United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendmen

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

May 17, 2004 SC 13G

OMB APPROVAL

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

April 14, 2004 SC 13G

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. _)*

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

February 17, 2004 EX-99

EX-99

EX-99 3 form4eyetechdec2003.htm FORM 4 JOINT FILER INFORMATION Exhibit 99 Form 4 Joint Filer Information Name: BB Biotech AG(1) Address: Vodergasse 3 8300 Schaffhausen CH/Switzerland Issuer & Ticker Symbol: Eyetech Pharmaceuticals Inc [EYET]) Date of Event Requiring Statement: 2/4/04 Signature: /s/ Roland Maier Signatory Authority for Biotech Growth N.V. and BB Biotech AG (1) Biotech Growth N.V. i

February 17, 2004 EX-99

EX-99

EX-99 3 form3eyetechdec2003.htm FORM 3 JOINT FILER INFORMATION Exhibit 99 Form 3 Joint Filer Information Name: BB Biotech AG(1) Address: Vodergasse 3 8300 Schaffhausen CH/Switzerland Issuer & Ticker Symbol: Eyetech Pharmaceuticals Inc [EYET] Date of Event Requiring Statement: 1/29/04 Signature: /s/ Roland Maier Signatory Authority for Biotech Growth N.V. and BB Biotech AG (1) Biotech Growth N.V. i

November 17, 2003 SC 13G

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response. . . 11 United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendmen

SC 13G 1 w91905sc13g.htm SCHEDULE 13G OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response. . . 11 United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Cell Therapeutics Inc. (Name of Issuer) Common Stock, no par value (Title of Class of Securities) 150-9

June 10, 2003 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)*

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

June 10, 2003 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)*

OMB APPROVAL OMB Number: 3235-0145 Expires: October 31, 2002 Estimated average burden hours per response.

February 14, 2003 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Adolor Corporation

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

February 14, 2003 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Neurocrine Biosciences, Inc.

SC 13G/A 1 w83576asc13gza.htm NEUROCRINE BIOSCIENCES SCHEDULE 13G OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response...11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Neurocrine Biosciences, Inc. (Name of Issuer) Common Stock (Title of Class of

February 14, 2003 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* CV Therapeutics, Inc.

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

February 14, 2003 EX-1

Joint Filing Statement

Exhibit 1 Joint Filing Statement Pursuant to Rule 13d-1(f)(1), we undersigned, hereby express our agreement that the attached Schedule 13G (including all amendments thereto) is filed on behalf of each of the undersigned.

February 14, 2003 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* MedImmune, Inc.

OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

February 14, 2003 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* The Medicines Company

SC 13G/A 1 w83576csc13gza.htm THE MEDICINES COMPANY SCHEDULE 13G OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response...11 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* The Medicines Company (Name of Issuer) Common Stock (Title of Class of Securit

February 14, 2003 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* 3-Dimensional Pharmaceuticals Inc.

sc13gza OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

February 14, 2003 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* ViroLogic, Inc.

sc13gza OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response.

July 1, 2002 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* GenVec, Inc.

OMB APPROVAL OMB Number: 3235-0145 Expires: October 31, 2002 Estimated average burden hours per response.

July 1, 2002 SC 13G/A

United States SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* The Medicines Company

OMB APPROVAL OMB Number: 3235-0145 Expires: October 31, 2002 Estimated average burden hours per response.

August 14, 2001 13F-HR

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE Report for Calendar Year or Quarter Ended: June 30, 2001 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: BB Biotech AG Address: Vordergasse 3 Grafenauweg

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